Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 31, 2024
Cuproptosis
is
a
recently
discovered
form
of
cell
death
that
mediated
by
copper
(Cu)
and
non-apoptotic
related
to
oligomerization
lipoylated
proteins
loss
Fe-S
protein
clusters.
Since
its
discovery,
cuproptosis
has
been
extensively
studied
researchers
for
mechanism
potential
applications
in
the
treatment
cancer.
Therefore,
this
article
reviews
specific
currently
studied,
as
well
principles
strategies
use
anti-cancer
treatment,
with
aim
providing
reference
cuproptosis-based
cancer
therapy.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1567 - 1567
Published: May 23, 2023
Disulfiram
(DSF)
is
a
thiocarbamate
based
drug
that
has
been
approved
for
treating
alcoholism
over
60
years.
Preclinical
studies
have
shown
DSF
anticancer
efficacy,
and
its
supplementation
with
copper
(CuII)
significantly
potentiates
the
efficacy
of
DSF.
However,
results
clinical
trials
not
yielded
promising
results.
The
elucidation
mechanisms
DSF/Cu
(II)
will
be
beneficial
in
repurposing
as
new
treatment
certain
types
cancer.
DSF’s
mechanism
primarily
due
to
generating
reactive
oxygen
species,
inhibiting
aldehyde
dehydrogenase
(ALDH)
activity
inhibition,
decreasing
levels
transcriptional
proteins.
also
shows
inhibitory
effects
cancer
cell
proliferation,
self-renewal
stem
cells
(CSCs),
angiogenesis,
resistance,
suppresses
metastasis.
This
review
discusses
current
delivery
strategies
alone
diethyldithocarbamate
(DDC),
Cu
(II),
efficacious
component
Diethyldithiocarbamate–copper
complex
(CuET).
Small,
Journal Year:
2023,
Volume and Issue:
19(24)
Published: March 18, 2023
Abstract
Chemotherapeutics
can
induce
immunogenic
cell
death
(ICD)
by
triggering
autophagy
and
mediate
antitumor
immunotherapy.
However,
using
chemotherapeutics
alone
only
cause
mild
cell‐protective
be
incapable
of
inducing
sufficient
ICD
efficacy.
The
participation
inducer
is
competent
to
enhance
autophagy,
so
the
level
promoted
effect
immunotherapy
highly
increased.
Herein,
tailor‐made
cascade
amplification
polymeric
nanoparticles
STF@AHPPE
are
constructed
tumor
Arginine
(Arg),
polyethyleneglycol–polycaprolactone,
epirubicin
(EPI)
grafted
onto
hyaluronic
acid
(HA)
via
disulfide
bond
form
AHPPE
STF‐62247
(STF)
loaded.
When
target
tissues
efficiently
enter
into
cells
with
help
HA
Arg,
high
glutathione
concentration
leads
cleavage
release
EPI
STF.
Finally,
induces
violent
cytotoxic
strong
As
compared
nanoparticles,
kill
most
show
more
obvious
efficacy
immune
activation
ability.
This
work
provides
a
novel
strategy
for
combining
chemo‐immunotherapy
induction.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 31, 2024
Cuproptosis
is
a
recently
discovered
form
of
cell
death
that
mediated
by
copper
(Cu)
and
non-apoptotic
related
to
oligomerization
lipoylated
proteins
loss
Fe-S
protein
clusters.
Since
its
discovery,
cuproptosis
has
been
extensively
studied
researchers
for
mechanism
potential
applications
in
the
treatment
cancer.
Therefore,
this
article
reviews
specific
currently
studied,
as
well
principles
strategies
use
anti-cancer
treatment,
with
aim
providing
reference
cuproptosis-based
cancer
therapy.
