Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158754 - 158754
Published: Dec. 1, 2024
Language: Английский
Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 17, 2025
Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.
Language: Английский
Citations
2
Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103515 - 103515
Published: Jan. 1, 2025
Language: Английский
Citations
2
Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529
Published: June 1, 2024
Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,
Language: Английский
Citations
9
Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122694 - 122694
Published: June 28, 2024
Language: Английский
Citations
8
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 674, P. 9 - 18
Published: June 21, 2024
Language: Английский
Citations
5
Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(11)
Published: Nov. 20, 2024
Abstract Copper (Cu), an indispensable micronutrient for the sustenance of living organisms, contributes significantly to a vast array fundamental metabolic processes. The human body maintains relatively low concentration copper, which is mostly found in bones, liver, and brain. Despite its concentration, Cu plays crucial role as element progression pathogenesis central nervous system (CNS) diseases. Extensive studies have been conducted recent years on copper homeostasis copper-induced cell death CNS disorders, including glioma, Alzheimer’s disease, Amyotrophic lateral sclerosis, Huntington’s stroke. Cuproptosis, novel pathway distinct from apoptosis, necrosis, pyroptosis, ferroptosis, has identified potentially intricately linked pathogenic mechanisms underlying various Therefore, systematic review cuproptosis their relationship with disorders could deepen our understanding these In addition, it may provide new insights strategies treatment disorders.
Language: Английский
Citations
5
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 9, 2025
Fungal infections pose a significant global public health threat, particularly candidemia and biofilm formation. Current antifungal drugs have limitations due to their toxicity drug resistance. Ion interference therapy, cuproptosis, shows potential for disease treatment. Herein, nano copper-chelate Cu(DDC)2@BSA (CDB) is synthesized research the mechanism of cuproptosis-like death investigated. Initially, CDB demonstrates strong inhibitory effect on multiple fungi exhibits activity against two fluconazole-resistant clinical isolates. The decrease in ATPase mitochondrial membrane indicates that may involve dysfunction. Subsequently, transcriptome analysis reveals alterations genes related copper ions transport regulation, oxidative phosphorylation, function. Additionally, overload observed, along with an increase heat shock protein 70 levels lipoic acid synthetase expression. Given biofilms hinder penetration, quaternary ammonium chitosan microneedles are employed combination penetrate barrier enhance effect. Overall, this study provides new insight into presents promising strategy fungal infection treatment through microneedle delivery system.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113562 - 113562
Published: Feb. 22, 2025
Language: Английский
Citations
0
Advanced Biology, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101781 - 101781
Published: April 17, 2025
Depression and cognitive disorders remain major challenges in healthcare, with conventional treatments often facing limitations such as slow onset, side effects, poor drug delivery to the brain. Biomimetic nanodelivery systems, including nanozymes, cell membrane-based exosomes, have emerged promising solutions these issues. These systems leverage natural biological processes enhance targeting, improve bioavailability, regulate complex pathways. Nanoenzymes, their catalytic properties, offer antioxidant anti-inflammatory benefits, while membranes exosomes provide efficient targeting immune evasion. However, remain, immaturity of large-scale production techniques, stability concerns, incomplete understanding mechanisms action. Moreover, long-term safety, pharmacokinetics, toxicity require further investigation. Despite obstacles, potential biomimetic revolutionize depression treatment is significant. Future research should focus on optimizing preparation, improving release, ensuring clinical safety. Multidisciplinary collaboration will be essential for advancing from laboratory practice, offering new therapeutic avenues other neurological disorders.
Language: Английский
Citations
0