Integrating Melt Electrowriting and Fused Deposition Modeling to Fabricate Hybrid Scaffolds Supportive of Accelerated Bone Regeneration DOI Creative Commons
Kian F. Eichholz, Pierluca Pitacco, Ross Burdis

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(3)

Published: Nov. 7, 2023

Emerging additive manufacturing (AM) strategies can enable the engineering of hierarchal scaffold structures for guiding tissue regeneration. Here, advantages two AM approaches, melt electrowriting (MEW) and fused deposition modelling (FDM), are leveraged integrated to fabricate hybrid scaffolds large bone defect healing. MEW is used a microfibrous core guide healing, while FDM stiff outer shell mechanical support, with constructs being coated pro-osteogenic calcium phosphate (CaP) nano-needles. Compared alone, prevent soft collapse into region support increased vascularization higher levels new formation 12 weeks post-implantation. In an additional group, also functionalized BMP2 via binding CaP coating, which further accelerates healing facilitates complete bridging defects after weeks. Histological analyses demonstrate that such well-defined annular bone, open medullary cavity, smooth periosteal surface, no evidence abnormal ectopic formation. These results potential integrating different approaches development regenerative biomaterials, in particular, enhanced outcomes possible MEW-FDM constructs.

Language: Английский

Biomaterials evolution: from inert to instructive DOI
Sajid Iqbal, Muhammad Sohail,

Shiji Fang

et al.

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(18), P. 6109 - 6115

Published: Jan. 1, 2023

The Evolution of Biomaterials: A Remarkable Journey Fueled by Materials Science and Engineering Advancements, redefining the landscape biomaterials field.

Language: Английский

Citations

16
Mechanism and application of 3D-printed degradable bioceramic scaffolds for bone repair DOI Creative Commons
Hui‐Yi Lin, Liyun Zhang, Qiyue Zhang

et al.

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(21), P. 7034 - 7050

Published: Jan. 1, 2023

3D-printed biodegradable bioceramic materials have a broad research base and application prospects for bone repair applications.

Language: Английский

Citations

15
Gelatin/Hyaluronic Acid Photocrosslinked Double Network Hydrogel with Nano-Hydroxyapatite Composite for Potential Application in Bone Repair DOI Creative Commons

Jianuo Zheng,

Yunping Wang, Yuwen Wang

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(9), P. 742 - 742

Published: Sept. 13, 2023

The application of hydrogels in bone repair is limited due to their low mechanical strength. Simulating extracellular matrix, methylacrylylated gelatin (GelMA)/methylacrylylated hyaluronic acid (HAMA)/nano-hydroxyapatite(nHap) composite were prepared by combining the double network strategy and nHap this study. precursor solutions injectable shear thinning property. compressive elastic modulus hydrogel was significantly enhanced, fracture strength nearly reached 1 MPa, retained its high water content at above 88%. possess good compatibility with BMSCS have potential be used as for defect treatment.

Language: Английский

Citations

14
Self‐Mineralizing Dnazyme Hydrogel as a Multifaceted Bone Microenvironment Amendment for Promoting Osteogenesis in Osteoporosis DOI
Haiping Wu, Shun Huang, Ying Zhu

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(19)

Published: Feb. 26, 2023

Abstract The accumulation of reactive oxygen species (ROS) and minimal osteogenic raw material in the osteoporotic bone microenvironment greatly inhibits activity osteoblasts. Herein, it is originally proposed to construct a biomatrix multifaceted amendment ‐Mineralized zippered G4‐Hemin DNAzyme hydrogel (MDH)‐to improve capacity promote high‐quality defect repair. programmed design rolling circle amplified DNA synthesis system allows introduction massive amounts MDH. highly mimics tight catalytic configuration horseradish peroxidase exerts excellent enzyme‐like with considerable ROS molecule scavenging ability. In addition, amplification by‐product pyrophosphate ingeniously employed as sufficient phosphorus source, thus constituting an autonomous mineralization for waste reuse through hydrolase calcium ions, which deposits MDH addresses challenge bio‐application stability. remarkable vitro vivo outcomes demonstrate that can effectively oxidative stress status osteoblasts, restore balance mitochondrial membrane potential, reduce apoptosis, ultimately demonstrating superior capacity.

Language: Английский

Citations

13
Integrating Melt Electrowriting and Fused Deposition Modeling to Fabricate Hybrid Scaffolds Supportive of Accelerated Bone Regeneration DOI Creative Commons
Kian F. Eichholz, Pierluca Pitacco, Ross Burdis

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(3)

Published: Nov. 7, 2023

Emerging additive manufacturing (AM) strategies can enable the engineering of hierarchal scaffold structures for guiding tissue regeneration. Here, advantages two AM approaches, melt electrowriting (MEW) and fused deposition modelling (FDM), are leveraged integrated to fabricate hybrid scaffolds large bone defect healing. MEW is used a microfibrous core guide healing, while FDM stiff outer shell mechanical support, with constructs being coated pro-osteogenic calcium phosphate (CaP) nano-needles. Compared alone, prevent soft collapse into region support increased vascularization higher levels new formation 12 weeks post-implantation. In an additional group, also functionalized BMP2 via binding CaP coating, which further accelerates healing facilitates complete bridging defects after weeks. Histological analyses demonstrate that such well-defined annular bone, open medullary cavity, smooth periosteal surface, no evidence abnormal ectopic formation. These results potential integrating different approaches development regenerative biomaterials, in particular, enhanced outcomes possible MEW-FDM constructs.

Language: Английский

Citations

13