Tumor-derived systems as novel biomedical tools—turning the enemy into an ally

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Cancer is a complex illness that presents significant challenges in its understanding and treatment. The classic definition, "a group of diseases characterized by the uncontrolled growth spread abnormal cells body," fails to convey intricate interaction between many entities involved cancer. Recent advancements field cancer research have shed light on role played individual tumor microenvironment as whole development progression. This breakthrough enables utilization components biological tools, opening new possibilities. article delves deeply into concept "tumor-derived systems", an umbrella term for tools sourced from aid combatting it. It includes cell membrane-coated nanoparticles (for theranostics), extracellular vesicles diagnosis/therapy), lysates vaccine development), engineered cells/organoids research). review seeks offer complete overview tumor-derived materials are utilized research, well their current stages implementation. aimed primarily at researchers working interface biology biomedical engineering, it provides vital insights this fast-growing topic.

Language: Английский

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Manganese‐Based Immunomodulatory Nanocomposite with Catalase‐Like Activity and Microwave‐Enhanced ROS Elimination Ability for Efficient Rheumatoid Arthritis Therapy

Small, Journal Year: 2023, Volume and Issue: 19(50)

Published: Aug. 26, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disease commonly associated with the accumulation of hyperactive immune cells (HICs), particularly macrophages pro-inflammatory (M1) phenotype, accompanied by elevated level reactive oxygen species (ROS), decreased pH and O2 content in joint synovium. In this work, an immunomodulatory nanosystem (IMN) developed for RA therapy modulating restoring function HICs inflamed tissues. Manganese tetraoxide nanoparticles (Mn3 O4 ) anchored on UiO-66-NH2 are designed, then hybrid coated Mn-EGCG film, further wrapped HA to obtain final nanocomposite @Mn3 /Mn-EGCG@HA (termed as UMnEH). When UMnEH diffuses inflammatory site synovium, stimulation microwave (MW) irradiation low trigger slow dissociation film. Then endogenously overexpressed hydrogen peroxide (H2 disintegrates exposed Mn3 NPs promote ROS scavenging generation. Assisted MW irradiation, microenvironment down-regulates expression hypoxia-inducible factor-1α (HIF-1α). Coupled clearance ROS, it promotes re-polarization M1 phenotype into anti-inflammatory (M2) macrophages. Therefore, multifunctional nanoplatform, IMN, exhibits promising potential modulate restore has exciting prospect treatment RA.

Language: Английский

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Multifunctional Nanoplatform for Mild Microwave-Enhanced Thermal, Antioxidative, and Chemotherapeutic Treatment of Rheumatoid Arthritis

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(8), P. 10341 - 10355

Published: Feb. 15, 2023

Rheumatoid arthritis (RA) is usually associated with excessive proliferation of M1-type proinflammatory macrophages, resulting in severe hypoxia and excess reactive oxygen species (ROS) the joint cavity. Inhibiting macrophages and/or repolarizing them into M2 phenotype anti-inflammatory cells by alleviating scavenging ROS could be a promising strategy for RA treatment. In this work, microwave-sensitive metal-organic framework UiO-66-NH2 constructed coating nanoenzyme cerium oxide (CeO2) loading drug celastrol (Cel) to give UiO-66-NH2/CeO2/Cel, which ultimately wrapped hyaluronic acid (HA) form nanocomposite UiO-66-NH2/CeO2/Cel@HA (UCCH). With microwave-susceptible properties UiO-66-NH2, thermal effect microwaves can eliminate inflammatory cells. addition, superoxide-like catalase-like activities originating from CeO2 UCCH are boosted scavenge accelerate decomposition H2O2 produce O2 under microwave irradiation. The nonthermal synergistically promote repolarization phenotype. Accompanied release anti-RA chemotherapeutic Cel, efficiently ameliorate vitro vivo through microwave-enhanced multisynergistic effects. This inspire design other platforms enhanced exploit new treatment modalities therapies.

Language: Английский

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Nanozyme-enhanced ferroptosis for cancer treatment

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 8(7), P. 1685 - 1702

Published: Jan. 1, 2024

Nanozymes could mimic the catalytic activity of natural enzymes, then stimulate Fenton reaction for reactive oxygen species overproduction and lipid peroxidation, ultimately induce ferroptosis to exert anticancer effects.

Language: Английский

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Redox-regulating nanotherapeutics potentiating ferroptosis-driven cancer treatment

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149518 - 149518

Published: Feb. 10, 2024

Language: Английский

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