Ferroptosis: Molecular perspective, cellular influence, cancer manifestation, and therapeutic potentials

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 105998 - 105998

Published: July 31, 2024

Language: Английский

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Self-assembled hyaluronic acid nanomicelle for enhanced cascade cancer chemotherapy via self-sensitized ferroptosis

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122489 - 122489

Published: July 14, 2024

Language: Английский

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Biodegradable Vanadium-Based Nanomaterials for Photothermal-Enhanced Tumor Ferroptosis and Pyroptosis

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

The designability and high reactivity of nanotechnology provide strategies for antitumor therapy by regulating the redox state in tumor cells. Here, we synthesize a kind vanadium dioxide nanoparticle encapsulated bovine serum albumin containing disulfide bonds (VSB NPs) photothermal-enhanced ferroptosis pyroptosis effects. Mechanism studies show that can effectively consume overexpressed glutathione (GSH) microenvironment, leading to decrease peroxidase 4 (GPX4) activity. Simultaneously, tetravalent induce catalytic reaction H2O2, producing plenty toxic hydroxyl radicals (·OH) singlet oxygen (1O2), cell ferroptosis. In addition, consumption also lead degradation nanoparticles into high-valent vanadates, activating thermal protein domain-associated 3 (NLRP3) inflammasomes causing pyroptosis. It is worth mentioning VSB NPs not only ablate cells under near-infrared light irradiation but further disrupt homeostasis thereby enhancing induced biodegradable vanadium-based nanomaterials. This strategy, based on biological effects regulate cells, provides possibilities cancer treatment.

Language: Английский

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Ros-Responsive Cationic Polymer Containing Ferrocene for Gene Delivery and Enhanced Tumor Cell Apoptosis/Ferroptosis

Published: Jan. 1, 2025

Language: Английский

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Synchronously Evoking Disulfidptosis and Ferroptosis via Systematical Glucose Deprivation Targeting SLC7A11/GSH/GPX4 Antioxidant Axis

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation cystine transporter solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 (SLC7A11/GSH/GPX4) antioxidant axis. However, disulfidptosis usually asynchronous due to opposite effect transport them. Herein, systematic glucose deprivation, by inhibiting upstream uptake promoting downstream consumption, is proposed synchronously evoke ferroptosis. As an example, Au nanodots Fe-apigenin (Ap) complexes coloaded FeOOH nanoshuttles (FeOOH@Fe-Ap@Au NSs) employed regulate SLC7A11/GSH/GPX4 axis performing disulfidptosis- ferroptosis-mediated therapy synchronously. In this scenario, exhibit oxidase-like activity when consuming massive glucose. Meanwhile, Ap can inhibit downregulating 1, depriving fundamentally. The systematical deprivation limits supplement NADPH suppresses axis, thus solving contradiction addition, efficient delivery exogenous iron ions FeOOH@Fe-Ap@Au NSs self-supplied H2O2 through nanodots-catalytic oxidation facilitate Fenton reaction therewith help amplify a result synchronous occurrence ferroptosis, good efficacy in ovarian cancer therapeutic model.

Language: Английский

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ROS-responsive cationic polymer containing ferrocene for gene delivery and enhanced tumor cell apoptosis/ferroptosis

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113953 - 113953

Published: April 1, 2025

Language: Английский

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Molecularly engineering a lipid nanoregulator destroying the last defense of ferroptosis in breast cancer therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153366 - 153366

Published: June 20, 2024

Language: Английский

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Multimodal enhancement of ferroptosis for synergistic cascade colorectal cancer therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155048 - 155048

Published: Aug. 28, 2024

Language: Английский

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Hybrid nano-stimulator for specific amplification of oxidative stress and precise tumor treatment

Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: June 4, 2024

The use of reactive oxygen species (ROS) to target cancer cells has become a hot topic in tumor therapy.

Language: Английский

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Therapeutic types and advantages of functionalized nanoparticles in inducing ferroptosis in cancer therapy

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: Sept. 14, 2024

The clinical efficacy of cancer treatment protocols remains unsatisfactory; however, the emergence ferroptosis-driven therapy strategies has renewed hope for tumor treatment, owing to their remarkable suppression effects. Biologically based small-molecule inducers are used in conventional method induce ferroptosis. Nevertheless, some molecular drugs have limited solubility, poor ability target cells, and fast metabolism, which hinder ferroptosis over a prolonged period. Fortunately, further investigations development nanotechnology demonstrated that nanoparticles (NPs) more efficient inducing than alone, opens up new perspectives therapy.

Language: Английский

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