Hydrogels and Wound Healing: Current and Future Prospects

Gels, Journal Year: 2024, Volume and Issue: 10(1), P. 43 - 43

Published: Jan. 5, 2024

The care and rehabilitation of acute chronic wounds have a significant social economic impact on patients global health. This burden is primarily due to the adverse effects infections, prolonged recovery, associated treatment costs. Chronic can be treated with variety approaches, which include surgery, negative pressure wound therapy, dressings, hyperbaric oxygen therapy. However, each these strategies has an array limitations. existing dry dressings lack functionality in promoting healing exacerbating pain by adhering wound. Hydrogels, are commonly polymer-based swell water, been proposed as potential remedies their ability provide moist environment that facilitates healing. Their unique composition enables them absorb exudates, exhibit shape adaptability, modified incorporate active compounds such growth factors antibacterial compounds. review provides updated discussion leading natural synthetic hydrogels utilized healing, details latest advancements hydrogel technology, explores alternate approaches this field. Search engines Scopus, PubMed, Science Direct, Web were advances applications over last fifteen years.

Language: Английский

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Injectable Self‐Expanding/Self‐Propelling Hydrogel Adhesive with Procoagulant Activity and Rapid Gelation for Lethal Massive Hemorrhage Management

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(15)

Published: Nov. 16, 2023

Developing hydrogels that can quickly reach deep bleeding sites, adhere to wounds, and expand stop lethal and/or noncompressible in civil battlefield environments remains a challenge. Herein, an injectable, antibacterial, self-expanding, self-propelling hydrogel bioadhesive with procoagulant activity rapid gelation is reported. This combines spontaneous gas foaming Schiff base crosslinking for massive hemorrhage. Hydrogels have expansion rate, high self-expanding ratio, excellent antibacterial activity, antioxidant efficiency, tissue adhesion capacity. In addition, good cytocompatibility, ability, higher blood cell/platelet than commercial combat gauze gelatin sponge. The optimized (OD-C/QGQL-A30) exhibits better hemostatic ability sponge rat liver femoral artery models, rabbit volumetric loss models with/without anticoagulant, kidney incision site not visible. Especially, OD-C/QGQL-A30 rapidly stops the bleedings from pelvic area of rabbit, swine subclavian vein transection. Furthermore, has biodegradability biocompatibility, accelerates Methicillin-resistant S. aureus (MRSA)-infected skin wound healing. opens up new avenue develop hemostats bleeding, abdominal organ coagulation lesions.

Language: Английский

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Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 305, P. 120545 - 120545

Published: Jan. 7, 2023

Language: Английский

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Chitosan-based injectable hydrogel with multifunction for wound healing: A critical review

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 333, P. 121952 - 121952

Published: Feb. 19, 2024

Language: Английский

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Water: The soul of hydrogels

Progress in Materials Science, Journal Year: 2024, Volume and Issue: unknown, P. 101378 - 101378

Published: Sept. 1, 2024

Language: Английский

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Self-healing, injectable chitosan-based hydrogels: Structure, properties and biological applications

Materials Advances, Journal Year: 2024, Volume and Issue: 5(13), P. 5365 - 5393

Published: Jan. 1, 2024

Conventional biomaterials suffer from mechanical stresses and biochemical degradation, compromising performance structural integrity.

Language: Английский

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A bioactive composite sponge based on biomimetic collagen fibril and oxidized alginate for noncompressible hemorrhage and wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122409 - 122409

Published: June 19, 2024

Language: Английский

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Multiple-dynamic-bond crosslinked ion-elastomers achieve a combination of photothermal antibacterial and self-powered electrical stimulation for infected wound healing

Nano Energy, Journal Year: 2024, Volume and Issue: 121, P. 109260 - 109260

Published: Jan. 5, 2024

Language: Английский

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Biodegradable alginate-based sponge with antibacterial and shape memory properties for penetrating wound hemostasis

Composites Part B Engineering, Journal Year: 2022, Volume and Issue: 247, P. 110263 - 110263

Published: Sept. 11, 2022

Language: Английский

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Biocompatible Cryogel with Good Breathability, Exudate Management, Antibacterial and Immunomodulatory Properties for Infected Diabetic Wound Healing

Advanced Science, Journal Year: 2023, Volume and Issue: 10(31)

Published: Sept. 4, 2023

Due to the complex microenvironment and healing process of diabetic wounds, developing wound dressing with good biocompatibility, mechanical stability, breathability, exudate management, antibacterial ability, immunomodulatory property is highly desired but remains a huge challenge. Herein, multifunctional cryogel designed prepared bio-friendly bacterial cellulose, gelatin, dopamine under condition sodium periodate oxidation. Bacterial cellulose can enhance stability by improving skeleton supporting effect crosslinking degree. The shows outstanding breathability management capability thanks interpenetrated porous structures. I

Language: Английский

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