Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 29, 2025
Skin
wound
healing
is
a
complex
physiological
process
that
involves
many
different
cell
types
and
signaling
molecules.
In
traditional
Chinese
medicine,
A.
membranaceus
Panax
notoginseng
are
commonly
used
together
for
the
treatment
of
injury
their
significant
efficacy.
The
application
new
materials
may
make
-P.
(AP)
play
better
curative
effect.
this
study,
we
fabricated
Carboxymethyl
chitosan-Sodium
alginate
hydrogel
loaded
with
extract
Astragalus
-
P.
(APCS),
which
showed
favorable
stability,
biocompatibility,
ability
to
rapidly
release
drugs.
Cell
culture
experiments
demonstrated
APCS
dramatically
increased
fibroblast
proliferation,
migration,
differentiation
into
myofibroblast.
vivo
on
SD
rats
hydrogels
significantly
accelerated
skin
healing,
reduced
inflammatory
response,
enhanced
formation
blood
vessels,
granulation
tissues,
collagen
fibers,
promoted
re-epithelialization
at
site.
Increased
expression
catalase,
VEGF,
PGP9.5
tissue
indicated
inhibited
oxidative
stress
vascular
neuronal
regeneration.
summary,
displayed
great
potential
as
dressing
achieving
satisfactory
full-thickness
wounds.
Acute
hemorrhage
death
on
battlefields,
during
clinical
surgeries,
and
in
major
accidents
is
a
widespread
worldwide
problem.
Clay-based
hemostatic
materials
have
received
considerable
attention
for
their
low
cost
reliable
clotting
activity,
especially
cases
of
severe
bleeding,
such
as
QuikClot,
which
kaolin-based
gauze
that
preferred
battlefield
resuscitation.
However,
the
easy
detachment
clay
particles
associated
risk
thrombosis
seriously
hindered
development
clay-based
materials.
Here,
inexpensive
palygorskite
(Pal)
nanoclay
was
integrated
into
collagen
(COL)
matrix
by
loading
Ca2+
further
using
gallic
acid
(GA)
to
mediate
robust
assembly
COL
matrix.
This
targeted
interfacial
design
simple
gentle
method
effectively
improves
dispersion
Pal
reduces
shedding.
Unlike
QuikClot
where
aqueous
solution
significantly
turbid
after
2
min
ultrasonic
washing,
composite
sponge
(Ca-Pal-GA-COL)
remained
clear
accompanied
82.71%
mass
residue
10
washing.
The
also
exhibited
excellent
antibacterial
(87.93%
inhibition
rate
Escherichia
coli),
antioxidant,
tissue
adhesion
properties.
Importantly,
Ca-Pal-GA-COL
less
blood
loss
(632
mg)
shorter
hemostasis
time
(151
s)
rat
femoral
artery
model
than
medical
(3850
mg
299
s),
pure
(1627
201
Pal-COL
(1494
193
co-mingled
mode,
are
comparable
those
(559
142
s).
Furthermore,
certain
properties
render
more
suitable
active
bleeding
scenarios.
Cellular
experiments
confirmed
dressing
has
biosafety.
Gels,
Journal Year:
2025,
Volume and Issue:
11(4), P. 271 - 271
Published: April 5, 2025
Collagen-based
wound
dressings
have
developed
as
an
essential
component
of
contemporary
care,
utilizing
collagen’s
inherent
properties
to
promote
healing.
This
review
thoroughly
analyzes
collagen
dressing
advances,
examining
different
formulations
such
hydrogels,
films,
and
foams
that
enhance
care.
The
important
processes
by
which
promotes
healing
(e.g.,
promoting
angiogenesis,
encouraging
cell
proliferation,
offering
structural
support)
are
discussed
clarify
its
function
in
tissue
regeneration.
effectiveness
adaptability
demonstrated
via
clinical
applications
investigated
acute
chronic
wounds.
Additionally,
commercially
accessible
collagen-based
skin
treatments
discussed,
demonstrating
their
practical
use
healthcare
settings.
Despite
the
progress,
study
discusses
obstacles
restrictions
encountered
producing
adopting
dressings,
difficulties
manufacturing
financial
concerns.
Finally,
current
landscape’s
insights
indicate
future
research
possibilities
for
optimization,
bioactive
agent
integration,
overcoming
existing
constraints.
analysis
highlights
potential
innovations
improve
treatment
methods
patient
