Dual‐Crosslinked Bioactive Hydrogel Scaffold for Accelerated Repair of Genital Tract Defect DOI
Liyang Wang,

Leong Chi Cheng,

Yu Chen

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

Abstract Reproductive health concerns like Mayer‐Rokitansky‐Küster‐Hauser (MRKH) syndrome are prevalent in today's society. MRKH is a condition that severely affects women's sexual life, fertility, and mental has high prevalence of one out 5000 female births. Vaginoplasty the primary method to regain patients’ reproductive health. However, conventional vaginoplasty faces various challenges, including complex non‐customized treatment procedures causing intense pains complications. To bring new advances vaginoplasty, 3D‐printed hydrogel scaffold developed provide satisfactory mechanical support bioactivity for accelerating defect repair after surgery. The consisting gelatin methacryloyl (gelMA) carrageenan (Car) custom using an ambient temperature printing system. Furthermore, undergoes dual‐crosslinking through chemical crosslinking gelMA ionic Car with magnesium ions (Mg 2+ ). This strategy substantially improves overall properties introduces bioactive Mg . sustained release plus extracts from dual‐crosslinked significantly promotes cell proliferation, migration angiogenesis. In preclinical rat model penetrating genital tract defects mimicking implantation repairs wounds near‐normal levels within week, showing potential as alternative better regaining

Language: Английский

Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy DOI Creative Commons
Minhao Wu, Huifan Liu, Dan Li

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(2)

Published: Nov. 7, 2023

Abstract The treatment of bone defects remains a substantial clinical challenge due to the lack spatiotemporal management immune microenvironment, revascularization, and osteogenic differentiation. Herein, deferoxamine (DFO)‐loaded black phosphorus nanosheets decorated by polydopamine layer are prepared (BPPD) compounded into gelatin methacrylate/sodium alginate methacrylate (GA) hybrid hydrogel as smart‐responsive therapeutic system (GA/BPPD) for accelerated regeneration. BPPD nanocomposites served bioactive components near‐infrared (NIR) photothermal agents, which conferred with excellent NIR/pH dual‐responsive properties, realizing stimuli‐responsive release DFO PO 4 3 − during Under action NIR‐triggered mild therapy, GA/BPPD exhibited positive effect on promoting osteogenesis angiogenesis, eliminating excessive reactive oxygen species, inducing macrophage polarization M2 phenotype. More significantly, through polarization‐induced osteoimmune this platform could also drive functional cytokine secretion enhanced angiogenesis osteogenesis. In vivo experiments further demonstrated that facilitate healing attenuating local inflammatory response, increasing pro‐healing factors, stimulating endogenous cell recruitment, accelerating revascularization. Collectively, proposed intelligent provides promising strategy reshape damaged tissue microenvironment augmented

Language: Английский

Citations

81
Vat photopolymerization-based 3D printing of polymer nanocomposites: current trends and applications DOI Creative Commons
Mussadiq Shah, Abid Ullah, Kashif Azher

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(2), P. 1456 - 1496

Published: Jan. 1, 2023

The synthesis and manufacturing of polymer nanocomposites have garnered interest in recent research development because their superiority compared to traditionally employed industrial materials.

Language: Английский

Citations

62
Multimaterial 3D and 4D Bioprinting of Heterogenous Constructs for Tissue Engineering DOI
Annan Chen, Wanying Wang, Zhengyi Mao

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(34)

Published: Sept. 22, 2023

Additive manufacturing (AM), which is based on the principle of layer-by-layer shaping and stacking discrete materials, has shown significant benefits in fabrication complicated implants for tissue engineering (TE). However, many native tissues exhibit anisotropic heterogenous constructs with diverse components functions. Consequently, replication biomimetic using conventional AM processes a single material challenging. Multimaterial 3D 4D bioprinting (with time as fourth dimension) emerged promising solution constructing multifunctional that can mimic host microenvironment better than single-material alternatives. Notably, 4D-printed multimaterial architectures provide time-dependent programmable dynamic promote cell activity regeneration response to external stimuli. This paper first presents typical design strategies TE applications. Subsequently, latest are discussed, along their advantages challenges. In particular, potential smart highlighted. Furthermore, this review provides insights into how facilitate realization next-generation

Language: Английский

Citations

57
Advancements in tissue and organ 3D bioprinting: Current techniques, applications, and future perspectives DOI Creative Commons

Mojdeh Mirshafiei,

Hamid Rashedi, Fatemeh Yazdian

et al.

Materials & Design, Journal Year: 2024, Volume and Issue: 240, P. 112853 - 112853

Published: March 19, 2024

3D bioprinting techniques have emerged as a flexible tool in tissue engineering and regenerative medicine to fabricate or pattern functional bio-structures with precise geometric designs, bridging the divergence between engineered natural constructs. A significantly increasing development has been achieved understanding relationship 3D-printing process structures, properties, applications of objects created. The ongoing advancement novel biomaterial inks enabled manufacturing models vitro implants capable achieving some level success preclinical trials. Remarkable progress cell biology biology-inspired computational design assisted latest milestone planned tissue- organ-like constructs having specific levels functionality. However, biofabricated still long way go before reaching clinics. This review presents picture context medicine, focus on biomaterials-related design-centred aspects. Biomedical are described detail relation major tissues organs considered human body. Current technical limitations, challenges, future prospects improvements critically outlined discussed.

Language: Английский

Citations

37
Bioelectronics for electrical stimulation: materials, devices and biomedical applications DOI
Ya Huang, Kuanming Yao, Qiang Zhang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8632 - 8712

Published: Jan. 1, 2024

Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat broad spectrum health conditions. Electrical stimulation (ES) pivotal technique in bioelectronics, offering precise, non-pharmacological means modulate control processes across molecular, cellular, tissue, organ levels. This method holds potential restore or enhance physiological functions compromised by diseases injuries integrating sophisticated electrical signals, device interfaces, designs tailored specific mechanisms. review explains mechanisms which ES influences cellular behaviors, introduces essential principles, discusses performance requirements for optimal systems, highlights representative applications. From this review, we can realize based bioelectronics therapy, regenerative medicine rehabilitation engineering technologies, ranging from tissue neurological modulation cardiovascular cognitive functions. underscores versatility various biomedical contexts emphasizes need adapt complex clinical landscapes addresses.

Language: Английский

Citations

22
Multi‐Material Digital Light Processing (DLP) Bioprinting of Heterogeneous Hydrogel Constructs with Perfusable Networks DOI
Ming Yang,

Lang Chu,

Yanfeng Zhuang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: April 8, 2024

Abstract The challenges of replicating the complex mechanical and structural diversity natural tissues in vitro by leveraging multi‐material digital light processing (DLP) bioprinting are addressed. This technique utilizes PEGDA‐AAm bio‐ink to develop multi‐component, cell‐laden hydrogel constructs with varying moduli. These not only possess heterogeneous properties but also feature architectures precisely engineered surface microstructures. microfluidic chips successfully fabricated perfusable microchannels, embedding various cell types within matrix. approach enables intricate structures unique topologies, such as spiral grooves triply periodic minimal surfaces (TPMS), which effectively influence alignment, spreading, migration. By integrating PA hydrogels, diverse moduli biological tissues, including bone, liver lobules, vascular networks replicated. ensures high‐fidelity differentiation between regions. findings provide valuable insights into impact substrate modulus structure on behavior, underscoring potential multi‐modulus creating sophisticated custom‐tailored properties. study significantly advances field demonstrating feasibility effectiveness DLP developing complex, functionally relevant tissue models for engineering regenerative medicine.

Language: Английский

Citations

17
Additive Manufactured Polymers in Dentistry, Current State-of-the-Art and Future Perspectives-A Review DOI Open Access
Codruța Victoria Țigmeanu, Lavinia Cosmina Ardelean, Laura Cristina Rusu

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(17), P. 3658 - 3658

Published: Sept. 3, 2022

3D-printing application in dentistry not only enables the manufacture of patient-specific devices and tissue constructs, but also allows mass customization, as well digital workflow, with predictable lower cost rapid turnaround times. 4D printing shows a good impact dentistry, it can produce dynamic adaptable materials, which have proven effective oral environment, under its continuously changing thermal humidity conditions. It is expected to further boost research into producing whole tooth, capable harmoniously integrate surrounding periodontium, represents ultimate goal engineering dentistry. Because their high versatility associated wide variety available additive manufacturing predominantly targets production polymeric constructs. The aim this narrative review catch glimpse current state-of-the-art future perspectives modern technology, focusing on specific materials.

Language: Английский

Citations

41
Recent Advances in 3D Printing of Polymers for Application in Prosthodontics DOI Open Access
Mariya Dimitrova, Angelina Vlahova,

Yavor Kalachev

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(23), P. 4525 - 4525

Published: Nov. 24, 2023

Contemporary mass media frequently depict 3D printing as a technology with widespread utilization in the creation of dental prosthetics. This paper endeavors to provide an evidence-based assessment current scope printing's integration within laboratories and practices. Its primary objective is offer systematic evaluation existing applications 3D-printing realm prosthetic restorations. Furthermore, this article delves into potential prospects, while also critically examining sustained relevance conventional laboratory services manufacturing procedures. The central focus expound upon extent which presently harnessed for crafting appliances. By presenting verifiable data factual insights, aspires elucidate actual implementation dentistry its seamless aim narrative review twofold: firstly, informed unbiased role that currently plays practices; secondly, instigate contemplation on transformative technology, both terms contemporary impact future implications, maintaining balanced consideration traditional approaches.

Language: Английский

Citations

31
Advances in precision microfabrication through digital light processing: system development, material and applications DOI Creative Commons
Xinhui Wang, Jinghang Liu, Yang Zhang

et al.

Virtual and Physical Prototyping, Journal Year: 2023, Volume and Issue: 18(1)

Published: Aug. 24, 2023

Formulae display:?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax order to improve their display. Uncheck the box turn off. This feature requires Javascript. Click on a formula zoom.

Language: Английский

Citations

28
Recent advances in harnessing biological macromolecules for wound management: A review DOI

Jingxuan Yuan,

Shuo Wang, Jie Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 130989 - 130989

Published: March 18, 2024

Language: Английский

Citations

11