Hybrid 3D microfluidic bioprinting for the engineering of cancer models and tissue substitutes DOI Creative Commons
Salvatore D’Alessandro, Sajad Mohammadi, Lucia Iafrate

et al.

Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 4, 2024

3D bioprinting is at the forefront of tissue engineering to fabricate complex constructs resembling functional tissues. However, inability produce heterogeneous tissues and lack spatio-temporal control over release bioactive factors are greatly limiting clinical translation. Herein, combination with high-throughput dispensing using a custom microfluidic system nanoclay-based inks presented. This approach was found enhance printability, retention, controlled factors. Advanced models were developed resemble cancer skeletal tissue, while studying effect anti-cancer (Doxorubicin) pro-osteogenic growth (bone morphogenetic protein-2, BMP-2), respectively. The new nanoclay ink allowed sustained release, making it suitable for long-term applications. These findings suggest that by combining delivery platform can be assembled, offering significant advancements in regenerative medicine.

Language: Английский

Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine DOI
Ben Jia,

Heyuan Huang,

Zhicheng Dong

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(8), P. 4086 - 4153

Published: Jan. 1, 2024

This review critically analyzes degradable biomedical elastomers, focusing on their degradation, synthesis, microstructure, and role in tissue repair. It guides experts balancing degradation with repair for improved applications.

Language: Английский

Citations

49
Advancements in tissue and organ 3D bioprinting: Current techniques, applications, and future perspectives DOI Creative Commons

Mojdeh Mirshafiei,

Hamid Rashedi, Fatemeh Yazdian

et al.

Materials & Design, Journal Year: 2024, Volume and Issue: 240, P. 112853 - 112853

Published: March 19, 2024

3D bioprinting techniques have emerged as a flexible tool in tissue engineering and regenerative medicine to fabricate or pattern functional bio-structures with precise geometric designs, bridging the divergence between engineered natural constructs. A significantly increasing development has been achieved understanding relationship 3D-printing process structures, properties, applications of objects created. The ongoing advancement novel biomaterial inks enabled manufacturing models vitro implants capable achieving some level success preclinical trials. Remarkable progress cell biology biology-inspired computational design assisted latest milestone planned tissue- organ-like constructs having specific levels functionality. However, biofabricated still long way go before reaching clinics. This review presents picture context medicine, focus on biomaterials-related design-centred aspects. Biomedical are described detail relation major tissues organs considered human body. Current technical limitations, challenges, future prospects improvements critically outlined discussed.

Language: Английский

Citations

37
Phase Engineering of Nanostructural Metallic Materials: Classification, Structures, and Applications DOI
Jialun Gu, Fenghui Duan, Sida Liu

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(3), P. 1247 - 1287

Published: Jan. 23, 2024

Metallic materials are usually composed of single phase or multiple phases, which refers to homogeneous regions with distinct types the atom arrangement. The recent studies on nanostructured metallic provide a variety promising approaches engineer phases at nanoscale. Tailoring size, distribution, and introducing new structures via transformation contribute precise modification in deformation behaviors electronic nanostructural materials. Therefore, engineering is expected pave an innovative way develop advanced mechanical functional properties. In this review, we present comprehensive overview heterogeneous nanophases fundamental understanding nanophase formation for materials, including supra-nano-dual-phase nanoprecipitation- nanotwin-strengthened We first review thermodynamics kinetics principles structure, followed by discussion mechanism structural as well optimization structure electrocatalysis. Then, demonstrate origin, classification, properties characteristics dense nanoprecipitations nanotwins. Finally, summarize some potential research challenges field short perspective scientific implications design next-generation

Language: Английский

Citations

35
4D bioprinting of programmed dynamic tissues DOI Creative Commons

Jiahui Lai,

Yuwei Liu, Gang Lü

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 37, P. 348 - 377

Published: April 23, 2024

Setting time as the fourth dimension, 4D printing allows us to construct dynamic structures that can change their shape, property, or functionality over under stimuli, leading a wave of innovations in various fields. Recently, smart biomaterials, biological components, and living cells into 3D constructs with effects has led an exciting field bioprinting. bioprinting gained increasing attention is being applied create programmed cell-laden such bone, cartilage, vasculature. This review presents overview on for engineering tissues organs, followed by discussion approaches, technologies, biomaterials design, bioink requirements, applications. While much progress been achieved, complex process facing challenges need be addressed transdisciplinary strategies unleash full potential this advanced biofabrication technology. Finally, we present future perspectives rapidly evolving bioprinting, view its potential, increasingly important roles development basic research, pharmaceutics, regenerative medicine.

Language: Английский

Citations

21
Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering DOI Creative Commons
Tomasz Górnicki, Jakub Lambrinow, Afsaneh Golkar‐Narenji

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(6), P. 531 - 531

Published: March 16, 2024

Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic adds complexity to traditional cell cultivation methods. most commonly used technique involves cultivating cells on flat surface in two-dimensional format due its simplicity. A three-dimensional (3D) provide microenvironment for surrounding cells. There two main techniques obtaining 3D structures based the presence scaffolding. Scaffold-free consist spheroid technologies. Meanwhile, scaffold contain organoids all constructs that various types scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels one extensively studied forms potential culture up 4D bioprinted biomaterials. bioprinting is important create scaffolds. versatility this allows many different inks, mainly hydrogels, as well inorganic substances. Increasing amounts data evidence vast usage engineering personalized medicine, with area application being regeneration skin musculoskeletal systems. Recent papers also indicate increasing vivo tests products which further strengthen importance branch emphasize need extensive research safe humansbiomimetic tissues organs. In review article, we recent advancements field preceded by an overview technologies led development complex type culture.

Language: Английский

Citations

20
Nacre-like carbon fiber-reinforced biomimetic ceramic composites: Fabrication, microstructure, and mechanical performance DOI
Hailong Wu, Anfu Guo, Dekun Kong

et al.

Ceramics International, Journal Year: 2024, Volume and Issue: 50(14), P. 25388 - 25399

Published: April 26, 2024

Language: Английский

Citations

16
Clinical applications of human organoids DOI
Monique M.A. Verstegen, Robert P. Coppes, Anne Béghin

et al.

Nature Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский

Citations

9
4D Bioprinting: Keeping the Technology Alive DOI Creative Commons
Patrick Imrie, Jianyong Jin

Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract 4D bioprinting is a groundbreaking technology with potential to revolutionize healthcare. It based on additive manufacturing technologies, which are used fabricate dynamic prosthetics and devices from biologically compatible smart materials that respond stimuli. The ultimate end of the creation an artificial organ perfectly mimics functional movements native fully integrated within human body. In this perspective, two phases identified toward end. first minimally invasive surgery (MIS) using shape memory composites stimulated by near‐infrared (NIR) light and/or magnetic fields. second tissue engineering (DTE) activation biological

Language: Английский

Citations

2
Construction of antibacterial bone implants and their application in bone regeneration DOI
Pei Feng,

Ruizhong He,

Yulong Gu

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(3), P. 590 - 625

Published: Nov. 10, 2023

In order to address the issue of bacterial infection during transplantation bone implants, four types implants with long-term antimicrobial functionality have been constructed.

Language: Английский

Citations

38
Photocuring 3D Printing of Hydrogels: Techniques, Materials, and Applications in Tissue Engineering and Flexible Devices DOI

Guoqiang Lu,

Ruifen Tang, Jun Nie

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: 45(7)

Published: Jan. 25, 2024

Photocuring 3D printing of hydrogels, with sophisticated, delicate structures and biocompatibility, attracts significant attention by researchers possesses promising application in the fields tissue engineering flexible devices. After years development, photocuring technologies hydrogel inks make great progress. Herein, techniques including direct ink writing (DIW), stereolithography (SLA), digital light processing (DLP), continuous liquid interface production (CLIP), volumetric additive manufacturing (VAM), two photon polymerization (TPP) are reviewed. Further, raw materials for (photocurable polymers, monomers, photoinitiators, additives) applications devices also At last, current challenges future perspectives hydrogels discussed.

Language: Английский

Citations

13