Reticular synthesis of a conductive composite derived from metal-organic framework and Mxene for the electrochemical detection of dopamine

Applied Surface Science, Journal Year: 2022, Volume and Issue: 613, P. 156103 - 156103

Published: Dec. 20, 2022

Language: Английский

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Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment

Biomacromolecules, Journal Year: 2023, Volume and Issue: 24(5), P. 2250 - 2263

Published: April 17, 2023

The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn's disease is extremely cloudy. Maintaining the level remission lesions in default treatment attitude at present. Epithelial barrier restoration considered as same important strategy colonic targeted drug delivery UC treatment. In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH enzyme dual sensitivity to reduce loss medication upper digestive tract preferentially adhere exposed epithelial cells tissues by electrostatic forces for efficiently Olsalazine an was loaded chitosan layer realized pH-responsive release. Furthermore, microspheres exhibited excellent capability suppressing harmful flora bio-adhesion effect extend duration local medicine. vivo anti-colitis study, downregulated levels pro-inflammatory factors increase tight junction protein indicated anti-inflammation olsalazine-loaded microspheres. summary, these results showed that could be powerful candidate system therapy.

Language: Английский

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A biomimetic nanoreactor for combinational chemo/chemodynamic therapy of choriocarcinoma through synergistic apoptosis and ferroptosis strategy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 472, P. 144690 - 144690

Published: July 16, 2023

Language: Английский

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Iron oxide nanoparticles (Fe3O4, γ-Fe2O3 and FeO) as photothermal heat mediators in the first, second and third biological windows

Physics Reports, Journal Year: 2023, Volume and Issue: 1043, P. 1 - 35

Published: Nov. 4, 2023

Nanotherapies are gaining increased interest for the treatment diverse diseases, particularly cancer, since they target affected area directly, presenting higher efficacy and reduced side effects than traditional therapies. A promising nanotherapy approach is hyperthermia, where nanoparticle can induce a local temperature increase by an external stimulus in sick tissue to selectively kill malignant cells. Among hyperthermia methods, photothermia based on absorption of light nanoparticles further conversion into heat. Within very wide range nanostructured photothermal agents, iron oxides offer remarkable features already approved FDA/EMA various biomedical applications, biodegradable, easily manipulated using magnetic fields be imaged techniques. Here, we summarize advantages second biological window, both from perspective skin optical properties oxides. Further, review performance oxide first, third windows. Overall, results show that, different types (Fe3O4, γ-Fe2O3, wüstite-FeO), heating capacity (i.e., induced increase) efficiency, η, vary complex way with wavelength, depending critically measurement conditions physiochemical materials. Despite spread reported oxides, Fe3O4 particles tend perform better their γ-Fe2O3 counterparts, window. Interestingly, FeO, which has not been exploited so far perspective, shows appealing properties. Our preliminary studies FeO/Fe3O4 core/shell evidence that have excellent properties, outperforming first Finally, some applications beyond cancer nanoparticles, exploiting enhanced spectral discussed.

Language: Английский

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Enhanced chemodynamic therapy and immunotherapy by hypoxia augmentation for tumor ablation

Nano Today, Journal Year: 2023, Volume and Issue: 51, P. 101899 - 101899

Published: June 15, 2023

Language: Английский

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