Fundamental Research, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 66 - 97
Published: Sept. 29, 2023
Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.
Language: Английский
Citations
51
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: June 10, 2024
Abstract The problem of antimicrobial resistance (AMR) caused by the abuse antibiotics is becoming serious. development antibacterial materials with synergistic efficiency and treatment deep tissue/organ infections imminent. Herein, nanoparticles (MPH NPs) are prepared loading peptide polymyxin B (PMB) on Fe‐based MOF (MIL‐100) hyaluronic acid (HA) modification. MPH NPs exerts effects chemodynamic therapy (CDT) release PMB. have broad‐spectrum properties Gram‐negative bacteria ( E. coli , 100%), Gram‐positive S. aureus 98.5 %), MRSA (98.4%). Importantly, not only promote healing infected wounds but also target lungs to accomplish organ infection therapy. Therefore, this study provides a new strategy for designing synergetic anti‐AMR system function in future.
Language: Английский
Citations
17
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.
Language: Английский
Citations
4
Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(2)
Published: Jan. 16, 2025
Language: Английский
Citations
2
Advanced Science, Journal Year: 2024, Volume and Issue: 11(23)
Published: March 15, 2024
Abstract Bioenergetic therapy is emerging as a promising therapeutic approach. However, its effectiveness restricted by metabolic plasticity, tumor cells switch phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) to compensate for energy. Herein, Metformin (MET) BAY‐876 (BAY) co‐loaded CuFe 2 O 4 (CF) nanoplatform (CFMB) developed boost energy deprivation synchronous interventions of OXPHOS bioenergetic synergetic with chemodynamic/photothermal (CDT/PTT). The MET can simultaneously restrain inhibiting hexokinase (HK2) activity damaging mitochondrial function deprive energy, respectively. Besides, BAY blocks glucose uptake transporter 1 (GLUT1) expression, further potentiating the repression thus achieving much more depletion tumorigenic sources. Interestingly, upregulated antioxidant glutathione (GSH) in cancer triggers CFMB degradation release Cu + /Fe 2+ catalyzing tumor‐overexpressed H hydroxyl radical (∙OH), both impairing GSH‐depletion amplified CDT. Furthermore, upon near‐infrared (NIR) light irradiation, has photothermal conversion capacity kill PTT improve ∙OH production enhanced In vivo experiments have manifested that remarkably suppressed growth mice without systemic toxicity. This study provides new modality paradigm bioenergetic‐related therapies.
Language: Английский
Citations
14
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 239, P. 113911 - 113911
Published: April 11, 2024
Language: Английский
Citations
10
ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(5), P. 1593 - 1605
Published: March 22, 2024
Chemodynamic therapy (CDT) exhibits unsatisfactory therapeutic efficacy for colorectal cancer (CRC) due to the hyposensitive Fenton reaction. Herein, we constructed a novel multifunctional nanoplatform based on bismuth-doped iron selenide nanoparticles (BFS NPs) promoting performance of CDT CRC. BFS NPs can realize and second near-infrared photothermal (NIR-II PTT) by means reaction an excellent conversion efficiency (η = 31.9%). Moreover, rising temperature induced NIR irradiation accelerates rate because there being more activated H2O2, thereby improving reactive oxygen species (ROS) levels address insufficient hydrogen peroxide concentration. The results showed that combination with NIR-II PTT significantly inhibits growth CRC minimizes adverse reactions. Meanwhile, bismuth doping endows superior CT imaging T2-weighted magnetic resonance (T2-MRI) capacities. These unique properties offer appropriate treatment time window guiding PTT. In summary, this improves effect accurately regulates MRI/CT guidance, which provides new perspective effective precise
Language: Английский
Citations
9
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 216040 - 216040
Published: June 20, 2024
Language: Английский
Citations
9
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 149248 - 149248
Published: Feb. 2, 2024
Language: Английский
Citations
8
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 646 - 658
Published: Oct. 25, 2024
Language: Английский
Citations
5