Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 149068 - 149068
Published: Jan. 1, 2024
Language: Английский
ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15962 - 15977
Published: Aug. 3, 2023
Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.
Language: Английский
Citations
120
ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(7), P. 1787 - 1830
Published: May 26, 2023
Due to the good reliability and long-term stability, self-healing hydrogels have emerged as promising soft materials for tissue engineering, smart wearable sensors, bioelectronics, energy storage devices. The mechanism depends on reversible chemical or physical cross-linking interactions. Self-healing with fascinating features (including mechanical performances, biocompatibility, conductivity, antibacterial ability, responsiveness, etc.) are being designed developed according practical application requirements. In this review, recent progress in their synthesis strategies multiple applications is summarized. Their involve processes a combination of two. include flexible strain supercapacitors, actuators, adhesives, wound healing, drug delivery, tumor treatment, 3D printing, etc. Finally, current challenges, future development, opportunities discussed.
Language: Английский
Citations
86
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(10)
Published: Jan. 1, 2023
Abstract Diabetic foot ulcer (DFU) is one of the most common complications diabetes, bringing physical and mental challenges for patients due to lack efficient curative therapy. Despite considerable advances in pharmacological surgical approaches, clinical trials DFU remain disappointing local overactive excessive inflammation. Immunomodulatory hydrogels has significant advantages overcome challenge DFUs Here, recent fabrication regenerative utilization functional altering immune microenvironment are comprehensively reviewed. The pathological features healing processes DFUs, followed by summarizing physicochemical properties essential design immunomodulation briefly introduced. Then, potential immuno‐therapeutic modalities emerging trends used treat via multitherapeutic approaches enhanced efficacy safety discussed. Taken together, linking structural their functions therapy with a particular focus on immunomodulatory stimuli, this review can promote further designing advanced resulting improved diabetic wound repair through translation into setting near future.
Language: Английский
Citations
75
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)
Published: Aug. 1, 2023
Chronic wounds are characterized by delayed and dysregulated healing processes. As such, they have emerged as an increasingly significant threat. The associated morbidity socioeconomic toll clinically financially challenging, necessitating novel approaches in the management of chronic wounds. Metal-organic frameworks (MOFs) innovative type porous coordination polymers, with low toxicity high eco-friendliness. Documented anti-bacterial effects pro-angiogenic activity predestine these nanomaterials promising systems for treatment In this context, therapeutic applicability efficacy MOFs remain to be elucidated. It is, therefore, reviewed structural-functional properties their composite materials discusses how multifunctionality customizability can leveraged a clinical therapy
Language: Английский
Citations
74
ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2533 - 2547
Published: May 24, 2024
Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel (GGG) with inherent capabilities IDFUs. GGG is composed interpenetrating polymer networks featuring gallium-induced self-assembling glycyrrhizic acid photo-cross-linked gelatin methacryloyl matrix. Importantly, effectively decreases ratio conditions drug-resistant by disrupting iron metabolism scavenging reactive oxygen species, which contributes enhanced treatment results wounds. To sum up, strategy present provides straightforward, safe, highly effective therapeutic avenue managing
Language: Английский
Citations
69
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 1537 - 1560
Published: March 1, 2023
Abstract: Diabetes mellitus (DM) induced wound healing impairment remains a serious health problem and burden on the clinical obligation for high amputation rates. Based features of microenvironment, biomaterials loading specific drugs can benefit diabetic treatment. Drug delivery systems (DDSs) carry diverse functional substances to site. Nano-drug (NDDSs), benefiting from their related nano size, overcome limitations conventional DDSs application are considered as developing process in treatment field. Recently, number finely designed nanocarriers efficiently various (bioactive non-bioactive factors) have emerged circumvent constraints faced by traditional DDSs. This review describes recent advances nano-drug involved mitigating diabetes mellitus-based non-healing wounds. Keywords: drug system, nanotechnology, healing, nanoparticles
Language: Английский
Citations
48
Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 168, P. 580 - 592
Published: July 13, 2023
Language: Английский
Citations
44
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: Feb. 6, 2024
Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.
Language: Английский
Citations
38
ACS Nano, Journal Year: 2024, Volume and Issue: 18(9), P. 7024 - 7036
Published: Feb. 23, 2024
Chronic wounds frequently arise as a complication in diabetic patients, and their management remains significant clinical hurdle due to nonhealing nature featured by heightened oxidative stress impaired healing cells at the wound site. Herein, we present 2D copper antioxidant nanozyme induced phenolic ligand–metal charge transfer (LMCT) eliminate reactive oxygen species (ROS) facilitate of chronic wounds. We found that polyphenol ligands coordinated on Cu3(PO4)2 nanosheets led strong interface regulated valence states Cu. The obtained Cu exhibited efficient scavenging ability toward different protected human from damage. enhanced promoting re-epithelialization, collagen deposition, angiogenesis, immunoregulation. This work demonstrates LMCT-induced ROS nanointerface, providing an alternative strategy constructing metal-based nanozymes for treatment well other diseases.
Language: Английский
Citations
38
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(22)
Published: Feb. 2, 2024
Abstract For various chronic wounds, bacterial infection is one of the important reasons that hinder their healing. Ion‐crosslinked antibacterial hydrogel dressings based on Ag + , Cu 2+ and Zn have made progress in clinical application. However, toxicity released metal ions cannot be ignored. Therefore, how to ensure performance dressing while reducing amount a major challenge for fabrication ion hydrogel. In this study, general method proposed design cationic ion‐crosslinked thiourea groups. Taking formed by mixing modified hyaluronic acid (H‐ANCSN) with (HA‐NCSN/Ag hydrogel) as an example, characteristics application potential kind are thoroughly explored. Due strong chelation groups, HA‐NCSN/Ag can gel at low concentration achieve long‐term slow release stable balance biocompatible properties. Moreover, dynamic thiourea‐Ag crosslinking also endowed property “gelation encapsulation first, injection cover wound when necessary”. Then, mangiferin self‐assembled nanoparticles loaded into radical oxygen species scavenger.
Language: Английский
Citations
36