Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 307 - 338
Published: Jan. 1, 2025
Language: Английский
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1829 - 1829
Published: June 26, 2023
Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, well spatial structure which mimics the extracellular matrix. However, use of nanofibers achieve controlled loading release still presents many challenges, with ongoing research exploring how load drugs onto nanofiber without loss activity control in specific spatiotemporal manner. This comprehensive study systematically reviews applications recent advances related drug-laden skin-wound management. First, we introduce commonly used methods preparation, electrostatic spinning, sol-gel, molecular self-assembly, thermally induced phase separation, 3D-printing techniques. Next, summarize polymers preparation utilizing scaffolds. We then review application drug-loaded considering different stages healing acts. Finally, briefly describe stimulus-responsive schemes scaffolds, other exciting systems.
Language: Английский
Citations
72
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(10)
Published: Jan. 2, 2024
The presence of bacteria in diabetic wounds not only leads to the formation biofilms but also triggers oxidative stress and inflammatory responses, which hinder wound-healing process. Therefore, it is imperative formulate a comprehensive strategy that can proficiently eliminate enhance wound microenvironment. Herein, this work develops multifunctional metal-phenolic nanozymes (TA-Fe/Cu nanocapsules), wherein one-pot coordination tannic acid (TA)and Fe
Language: Английский
Citations
36
RSC Pharmaceutics, Journal Year: 2024, Volume and Issue: 1(1), P. 9 - 36
Published: Jan. 1, 2024
The physical properties of asiaticoside (AC), such as its high molecular weight, poor water solubility, and low permeability, restrict therapeutic benefits. AC-loaded nano-carriers overcome AC limitations in wound healing by enhancing delivery efficiency, stability, safety.
Language: Английский
Citations
18
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
Since their inception in the early 1960s, development and use of nanoscale materials have progressed tremendously, roles diverse fields ranging from human health to energy electronics are undeniable. The application nanotechnology inventions has revolutionized many aspects everyday life including various medical applications specifically drug delivery systems, maximizing therapeutic efficacy contained drugs by means bioavailability enhancement or minimization adverse effects. In this review, we utilize CAS Content Collection, a vast repository scientific information extracted journal patent publications, analyze trends nanoscience research relevant an effort provide comprehensive detailed picture field. We examine publication landscape area insights into current knowledge advances developments. review major classes nanosized routes, targeted diseases. outline most discussed concepts assess advantages nanocarriers. objective is broad overview evolving regarding challenges, evaluate growth opportunities. merit stems extensive, wide-ranging coverage up-to-date information, allowing unmatched breadth analysis in-depth insights.
Language: Английский
Citations
2
Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(3), P. 1056 - 1076
Published: Jan. 30, 2024
Human skin is the largest organ and outermost surface of human body, due to continuous exposure various challenges, it prone develop injuries, customarily known as wounds. Although tissue engineering strategies bioactive wound matrices have been employed speed up healing, scarring remains a significant challenge. The environment harsh presence degradative enzymes elevated pH levels, physiological processes involved in regeneration operate on distinct time scales. Therefore, there need for effective drug delivery systems (DDSs) address these issues. objective this review provide comprehensive exposition mechanisms underlying healing process, factors materials used DDSs, different DDSs care. Furthermore, investigation will delve into examination emergent technologies potential avenues enhancing efficacy care devices.
Language: Английский
Citations
11
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101553 - 101553
Published: Feb. 5, 2025
Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient
Language: Английский
Citations
1
Materials Advances, Journal Year: 2023, Volume and Issue: 4(15), P. 3091 - 3113
Published: Jan. 1, 2023
This review aims to provide an overview of nanoparticles for diabetes mellitus therapy. It explores the properties, synthesis and/or functionalization, mechanistic aspects, and therapeutics its complications.
Language: Английский
Citations
21
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105665 - 105665
Published: April 16, 2024
Language: Английский
Citations
7
BMC Complementary Medicine and Therapies, Journal Year: 2024, Volume and Issue: 24(1)
Published: Jan. 25, 2024
Abstract Aims Thymus plant is a very useful herbal medicine with various properties such as anti-inflammatory and antibacterial. Therefore, the of this have made drug suitable candidate for wound healing. In study, hydroxypropyl methylcellulose (HPMC) gel containing Zataria multiflora volatile oil nanoemulsion (neZM) along polycaprolactone/chitosan (PCL-CS) nanofibrous scaffold was used, effect three experimental groups on healing process evaluated. The first group, HPMC neZM, second PCL-CS nanofibers, third neZM bandaged nanofibers (PCL-CS/neZM). Wounds common sterile gas were considered control. Methods synthesized by spontaneous method loaded into gel. DLS test investigated size these nanoemulsions. A also electrospinning then SEM contact angle tests morphology hydrophilicity/hydrophobicity its surface. animal study performed full-thickness skin wounds in rats, tissue regeneration control evaluated H&E Masson's trichrome staining. Results results showed that has 225±9 nm an acceptable dispersion. show non-beaded smooth fibers due to presence chitosan hydrophilic properties, higher surface hydrophobicity than PCL fibers. PCL-CS/neZM group significantly reduced compared other 7th, 14th, 21st days. histological could reduce parameters edema, inflammation, vascularity increase fibrosis, re-epithelialization, collagen deposition day 21. Conclusion treatment can effectively improve
Language: Английский
Citations
6
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(13), P. 3292 - 3306
Published: Jan. 1, 2024
Synthesis strategy of glucose-responsive intelligent hydrogels based on multifunctional nanocomposite nodes and their mechanism in diabetic infected wounds.
Language: Английский
Citations
6