Type 2 Diabetes Mellitus Mediated Oxidative Stress in Bone Tissues and Novel Challenges for Biomaterials DOI
Ruideng Wang, Shilong Su, Zhengyang Chen

et al.

Advanced Therapeutics, Journal Year: 2023, Volume and Issue: 7(2)

Published: Oct. 10, 2023

Abstract Type 2 diabetes mellitus is a chronic metabolic disease which can adversely affect the skeletal system, causing detrimental bone effects such as quality deterioration, loss of strength, increased fracture risk, and impaired healing. One major mechanisms increase in T2DM‐induced oxidative stress results an imbalance remodeling affects metabolism regeneration. Recently, ROS‐scavenging biomaterials have been identified type promising therapeutic substance to alleviate tissue microenvironment. The aim this review elaborate T2DM mediated tissues current application engineering provides novel insight into diabetic tissue.

Language: Английский

A Novel PTH‐Related Peptide Combined With 3D Printed Macroporous Titanium Alloy Scaffold Enhances Osteoporotic Osseointegration DOI
Junwu Wang, Renxin Chen, Bin Ren

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(29)

Published: Aug. 16, 2023

Previous parathyroid hormone (PTH)-related peptides (PTHrPs) cannot be used to prevent implant loosening in osteoporosis patients due the catabolic effect of local sustained release. A novel PTHrP (PTHrP-2) that can locally promote osseointegration macroporous titanium alloy scaffold (mTAS) and counteract slippage is designed. In vitro, PTHrP-2 enhances proliferation, adhesion, osteogenic differentiation bone marrow-derived mesenchymal stem cells (BMSCs) within mTAS. Further, it promotes migration, angiogenesis-related protein expression, angiogenesis human umbilical vein endothelial (HUVECs). Compared PTH(1-34), partially weaken osteoclast RAW 264.7 cells. Even an oxidative stress microenvironment, safeguards proliferation migration BMSCs HUVECs, reduces reactive oxygen species generation mitochondrial damage, preserves HUVECs. Sprague-Dawley (SD) rat model, therapeutic benefits PTHrP-2-releasing mTAS (mTASP2 ) ordinary implanted for 12 weeks via micro-CT, sequential fluorescent labeling, histology are compared. The results demonstrate mTASP2 exhibits high growth rate, without osteophyte formation. Consequently, unique synthesis properties holds potential assisting implants patients.

Language: Английский

Citations

15
Progress of structural scaffold biomaterials for bone tissue defect repair: A cutting-edge review DOI
Yang Zhao, Qianqian Wu, Chengwei Zhao

et al.

Composite Structures, Journal Year: 2024, Volume and Issue: 349-350, P. 118542 - 118542

Published: Sept. 1, 2024

Language: Английский

Citations

6
Application of Antioxidant Compounds in Bone Defect Repair DOI Creative Commons
Jiajia Wang, Yubing Zhang, Qingming Tang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 789 - 789

Published: June 28, 2024

Bone defects caused by trauma, tumor resection, and infections are significant clinical challenges. Excessive reactive oxygen species (ROS) usually accumulate in the defect area, which may impair function of cells involved bone formation, posing a serious challenge for repair. Due to potent ROS scavenging ability, as well potential anti-inflammatory immunomodulatory activities, antioxidants play an indispensable role maintenance protection health have gained increasing attention recent years. This narrative review aims give overview main research directions on application antioxidant compounds repair over past decade. In addition, positive effects various their biomaterial delivery systems summarized provide new insights exploring antioxidant-based strategies

Language: Английский

Citations

5
Honeycomb Bionic Graphene Oxide Quantum Dot/Layered Double Hydroxide Composite Nanocoating Promotes Osteoporotic Bone Regeneration via Activating Mitophagy DOI
Dan Li, Danni Dai, Jianrong Wang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Abstract Abnormal osteogenic and remodeling microenvironment due to osteoblast apoptosis are the primary causes of delayed fracture healing in osteoporotic patients. Magnesium (Mg) alloys exhibit biodegradability appropriate elastic moduli for bone defects osteoporosis, but effect on local disorder is still insufficient. Inspired by “honeycomb,” layered double hydroxide (LDH) with regular traps graphene oxide quantum dots (GOQDs) inlayed constructed pulsed electrodeposition generate GOQD/LDH composite nanocoatings surfaces Mg alloy substrates. The honeycomb bionic multi‐layer stereoscopic structure shows good regulation degradation support time required defect. Within its lattice, conducive osteogenesis provided both rescue GOQD LDH. rescued activation mitophagy clear dysfunctional mitochondria, where upregulation BNIP3 phosphorylation played a key role. rat model femoral confirmed improvement regeneration osseointegration coating. In summary, controllable excellent pro‐osteogenic performance demonstrated promising design strategy implants therapy defects.

Language: Английский

Citations

5
ROS-Responsive PLGA-NPs for Co-Delivery of DTX and DHA for Colon Cancer Treatment DOI Creative Commons
Roberta Cassano, Sonia Trombino, Federica Curcio

et al.

International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(2), P. 262 - 277

Published: April 25, 2024

The aim of this work was to evaluate the antineoplastic effect newly synthesized nanoparticles based on poly(lactic-co-glycolic acid) (PLGA) alone or PLGA esterified with 2,2′-[propane-2,2-diylbis (thio)] diacetic acid (TKL), loaded docetaxel (DTX) and/or docosahexaenoic (DHA), as innovative site-specific therapeutic carriers. obtained materials were characterized by FT-IR and 1H-NMR, while dimensional analysis performed Dynamic Light Scattering. encapsulation efficiency evaluated, in vitro skin permeation tests also performed. antitumor activity nanomaterial studied human adenocarcinoma HCT116 cell line. In particular, viability bidimensional culture, well tumor spheroids, conducted. use these nanocarriers could facilitate stable efficient delivery DTX DHA through upper segments gastrointestinal tract colon. addition, presence ROS-sensitive their matrix should promote release mass, where high levels reactive oxygen species be found.

Language: Английский

Citations

4
Nanomaterials‐Based Drug Delivery Systems for Therapeutic Applications in Osteoporosis DOI

Donghong Shi,

Yuling Li,

Meng Tian

et al.

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract The etiology of osteoporosis is rooted in the disruption intricate equilibrium between bone formation and resorption processes. Nevertheless, conventional anti‐osteoporotic medications hormonal therapeutic regimens currently employed clinical practice are associated with a multitude adverse effects, thereby constraining their overall efficacy potential. Recently, nanomaterials have emerged as promising alternative due to minimal side efficient drug delivery, ability enhance formation, aiding restoring balance. This review delves into fundamental principles remodeling microenvironment, well current treatment approaches for osteoporosis. It subsequently explores research status nanomaterial‐based delivery systems treatment, encompassing inorganic nanomaterials, organic cell‐mimicking carriers exosomes mimics emerging therapies targeting microenvironment. Finally, discusses potential nanomedicine treating outlines future trajectory this burgeoning field. aim provide comprehensive reference application strategies therapy, fostering further advancements innovations critical area medical

Language: Английский

Citations

0
Bioengineered bacterial extracellular vesicles for targeted delivery of an osteoclastogenesis-inhibitory peptide to alleviate osteoporosis DOI
Xiangxiang Kong, Han Liu,

Sumeng Chen

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113751 - 113751

Published: April 1, 2025

Language: Английский

Citations

0
Molecular mechanism of Achyranthis bidentatae radix and Morindae officinalis radix in osteoporosis therapy: An investigation based on network pharmacology, molecular docking, and molecular dynamics simulations DOI Creative Commons
Junwu Wang,

Yilong Huang,

Lanhong Guo

et al.

Biochemistry and Biophysics Reports, Journal Year: 2023, Volume and Issue: 36, P. 101586 - 101586

Published: Nov. 24, 2023

To investigate the targets and mechanism of Achyranthis bidentatae radix Morindae officinalis (ABR-MOR) for treatment osteoporosis (OP) by utilizing network pharmacology, molecular docking technology (MDT) dynamics simulation (MDS). The main drug active ingredients (DAIs) target genes ABR-MOR were screened TCMSP database. relevant OP obtained from GeneCards, DisGeNET, CTD databases. Venny mapping is used to determine potential in OP. analyzed using a protein‒protein interaction MCODE module, subjected GO KEGG enrichment analysis. binding sites conditions key DAIs core verified through MDT MDS. 32 212 screened; 1453 OP-related obtained, 118 mapped. results analysis showed that DAIs-OP mainly enriched biological processes such as response hormones, peptides, oxygen levels reactive species, positive regulation cell migration. signaling pathways immune-inflammatory response, proliferation, senescence, apoptosis, angiogenesis, estrogen pathway. Additionally, also bone metabolism-related differentiation osteoclast MDS wogonin, beta-sitosterol, americanin A, ABR-MOR, able form good ligand‒protein complexes with PTGS2, PTGS1, PRKACA, PGR, MAPK1, AKT1, RELA. This study preliminarily investigated targets, processes, involved combined application ABR MOR revealed may play therapeutic role regulating responses, cellular osteoblast differentiation, which provides theoretical basis further experimental validation new strategy

Language: Английский

Citations

8
The role of mitochondria in the peri‐implant microenvironment DOI Creative Commons
Xidan Zhang, Jiyu Sun, Min Zhou

et al.

Experimental Physiology, Journal Year: 2023, Volume and Issue: 108(3), P. 398 - 411

Published: Jan. 17, 2023

Abstract Osseointegration is a dynamic biological process in the local microenvironment adjacent to bone implant, which crucial for implant performance and success of surgery. Recently, role mitochondria peri‐implant during osseointegration has gained much attention. Mitochondrial regulation been verified be essential cellular events as therapeutic target diseases microenvironment. In this review, we summarize our current knowledge key milieu, including mitochondrial reactive oxygen species metabolism angiogenesis, polarization macrophage immune responses, formation resorption osseointegration, will contribute research field development new treatment strategies improve success. addition, indicate limitations understanding suggest topics further study.

Language: Английский

Citations

6
Mesenchymal stem cells and dental implant osseointegration during aging: from mechanisms to therapy DOI Creative Commons
Yang Ma, Siyuan Wang, Hui Wang

et al.

Stem Cell Research & Therapy, Journal Year: 2023, Volume and Issue: 14(1)

Published: Dec. 20, 2023

Abstract Dental implants are widely used to replace missing teeth, providing patients with unparalleled levels of effectiveness, convenience, and affordability. The biological basis for the clinical success dental is osseointegration. Bone aging a high-risk factor reduced osseointegration survival rates implants. In aged individuals, mesenchymal stem cells (MSCs) in bone marrow show imbalanced differentiation reduction osteogenesis an increase adipogenesis. This leads impaired implant failure. review focuses on molecular mechanisms underlying dysfunctional MSCs, which primarily include autophagy, transcription factors, extracellular vesicle secretion, signaling pathways, epigenetic modifications, microRNAs, oxidative stress. Furthermore, this addresses pathological changes MSCs that affect discusses potential therapeutic interventions enhance by manipulating MSC aging.

Language: Английский

Citations

6