Acid‐Ionizable Iron Nanoadjuvant Augments STING Activation for Personalized Vaccination Immunotherapy of Cancer

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(10)

Published: Dec. 28, 2022

The critical challenge for cancer vaccine-induced T-cell immunity is the sustained activation of antigen cross-presentation in antigen-presenting cells (APCs) with innate immune stimulation. In this study, it first discovered that clinically used magnetic contrast agents, iron oxide nanoparticles (IONPs), markedly augment type-I interferon (IFN-I) production profile stimulator genes (STING) agonist MSA-2 and achieve a 16-fold dosage-sparing effect human STING haplotype. Acid-ionizable copolymers are coassembled IONPs into nanoadjuvants to concentrate draining lymph nodes. top candidate nanoadjuvant (PEIM) efficiently delivers model ovalbumin (OVA) CD169+ APCs facilitates elicit 55-fold greater frequency antigen-specific CD8+ cytotoxic T-lymphocyte response than soluble antigen. PEIM@OVA nanovaccine immunization induces potent durable antitumor prevent tumor lung metastasis eliminate established tumors. Moreover, PEIM applicable deliver autologous synergizes checkpoint blockade therapy prevention postoperative recurrence distant B16-OVA melanoma MC38 colorectal models. acid-ionizable offers generalizable readily translatable strategy cascade personalized vaccination immunotherapy.

Language: Английский

---

The impact of lipid metabolism on breast cancer: a review about its role in tumorigenesis and immune escape

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: June 27, 2023

Abstract Background Breast cancer (BC) is the second most frequent type of in world and common among women, configuring a major challenge to global health. BC complex heterogeneous disease that can be subdivided into distinct tumor types based on expression molecular markers predicting patient outcomes response therapy. A growing number studies have tried expand known by investigating association altered lipid metabolism with immune escape, progression, metastasis. In this review, we describe metabolic peculiarities each subtype, understanding how influences its aggressiveness identifying whether these intrinsic vulnerabilities subtype play role therapeutic management may affect system cells microenvironment. Conclusion The evidence suggests so far when changes occur pathways, it availability structural lipids for membrane synthesis, degradation contribute energy homeostasis cell signaling functions. These findings will guide next steps path mechanisms underlying alterations are related disparities chemotherapeutic escape BC.

Language: Английский

---

Recent Progress in Anti‐Tumor Nanodrugs Based on Tumor Microenvironment Redox Regulation

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 25, 2024

Abstract The growth state of tumor cells is strictly affected by the specific abnormal redox status microenvironment (TME). Moreover, reactions at biological level are also central and fundamental to essential energy metabolism in tumors. Accordingly, anti‐tumor nanodrugs targeting disruption this homeostasis have become one hot spots field research due effectiveness TME modulation efficiency mediated interference. This review discusses latest results therapy, which regulate levels oxidants or reductants through a variety therapeutic strategies, ultimately breaking original “stable” promoting cell death. With gradual deepening study on vigorous development nanomaterials, it expected that more nano drugs based regulation will be designed even applied clinically.

Language: Английский

---

Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 201 - 201

Published: Feb. 10, 2025

Oxidative stress is a common event involved in cancer pathophysiology, frequently accompanied by unique lipid metabolic reprogramming phenomena. caused mainly an imbalance between the production of reactive oxygen species (ROS) and antioxidant system cells. Emerging evidence has reported that oxidative regulates expression activity metabolism-related enzymes, leading to alteration cellular metabolism; this involves significant increase fatty acid synthesis shift way which lipids are taken up utilized. The dysregulation metabolism provides abundant intermediates synthesize biological macromolecules for rapid proliferation cells; moreover, it contributes maintenance intracellular redox homeostasis producing variety reducing agents. Moreover, derivatives metabolites play critical roles signal transduction within cells tumor microenvironment evades immune destruction facilitates invasion metastasis. These findings suggest close relationship during malignant progression cancers. This review focuses on crosstalk reprogramming, in-depth insight into modulation ROS cancers discusses potential strategies targeting therapy.

Language: Английский

---

Preparation, characterization, bioactivity, and safety evaluation of PEI-modified PLGA nanoparticles loaded with polysaccharide from Cordyceps militaris

Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 8(1)

Published: Dec. 29, 2024

Language: Английский

---

DNA origami-based composite nanosandwich for iteratively potentiated chemo-immunotherapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 452 - 465

Published: Jan. 17, 2025

Language: Английский

---

Enhanced chemodynamic therapy and immunotherapy by hypoxia augmentation for tumor ablation

Nano Today, Journal Year: 2023, Volume and Issue: 51, P. 101899 - 101899

Published: June 15, 2023

Language: Английский

---

Strategic disruption of cancer’s powerhouse: precise nanomedicine targeting of mitochondrial metabolism

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 8, 2024

Abstract Mitochondria occupy a central role in the biology of most eukaryotic cells, functioning as hub oxidative metabolism where sugars, fats, and amino acids are ultimately oxidized to release energy. This crucial function fuels variety cellular activities. Disruption mitochondrial is common feature many diseases, including cancer, neurodegenerative conditions cardiovascular diseases. Targeting tumor cell with multifunctional nanosystems emerges promising strategy for enhancing therapeutic efficacy against cancer. review comprehensively outlines pathways metabolism, emphasizing their critical roles energy production metabolic regulation. The associations between aberrant initiation progression cancer highlighted, illustrating how these disruptions contribute oncogenesis sustainability. More importantly, innovative strategies employing nanomedicines precisely target therapy fully explored. Furthermore, key challenges future directions this field identified discussed. Collectively, provides comprehensive understanding current state potential nanomedicine targeting offering insights developing more effective therapies.

Language: Английский

---

Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4717 - 4737

Published: July 27, 2024

Over the past decade, research has increasingly identified unique dysregulations in lipid metabolism within tumor microenvironment (TME). Lipids, diverse biomolecules, not only constitute biological membranes but also function as signaling molecules and energy sources. Enhanced synthesis or uptake of lipids TME significantly promotes tumorigenesis proliferation. Moreover, secreted into influence tumor-resident immune cells (TRICs), thereby aiding survival against chemotherapy immunotherapy. This review aims to highlight recent advancements understanding both TRICs, with a particular emphasis on exogenous endogenous

Language: Английский

---

Nano-Based Strategies Aiming at Tumor Microenvironment for Improved Cancer Therapy

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Malignant tumors pose a considerable threat to human life and health. Traditional treatments, such as radiotherapy chemotherapy, often lack specificity, leading collateral damage normal tissues. Tumor microenvironment (TME) is characterized by hypoxia, acidity, redox imbalances, elevated ATP levels factors that collectively promote tumor growth metastasis. This review provides comprehensive overview of the nanoparticles developed in recent years for TME-responsive strategies or TME-modulating methods therapy. The focus on designing synthesizing can interact with achieve precisely controlled drug release. These activate release under specific conditions within environment, thereby enhancing efficacy drugs while reducing toxicity cells. Moreover, simply eliminating cells does not fundamentally solve problem. Only comprehensively regulating TME make it unsuitable cell survival proliferation we more thorough therapeutic effects reduce risk recurrence. regulation aim suppress metastasis modulating various components TME. only improve treatment outcomes but also have potential lay foundation future personalized cancer therapies.

Language: Английский

---