Engineering, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 534 - 548
Published: Feb. 22, 2024
Rehabilitation and regenerative medicine are two promising approaches for spinal cord injury (SCI) recovery, but their combination has been limited. Conductive biomaterials could bridge scaffolds with electrical stimulation by inducing axon regeneration supporting physiological signal transmission. Here, we developed aligned conductive hydrogel fibers incorporating carbon nanotubes (CNTs) into methacrylate acylated gelatin (GelMA) via rotating liquid bath electrospinning. The electrospun CNT/GelMA mimicked the micro-scale structure, conductivity, soft mechanical properties of neural axons. For
Language: Английский
Citations
26
Brain, Journal Year: 2023, Volume and Issue: 147(3), P. 766 - 793
Published: Nov. 15, 2023
Abstract Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent sensory, motor and autonomic impairments after SCI are substantially attributed to degeneration neurons axons, disintegration neural network. To date, minimal regenerative treatments available for with an unmet need new therapies reconstruct the damaged neuron-glia network restore connectivity supraspinal pathways. Multipotent precursor cells (NPCs) have unique capacity generate neurons, oligodendrocytes astrocytes. Due this capacity, NPCs been attractive cell source cellular SCI. Transplantation has extensively tested in preclinical models past two decades. These studies identified opportunities challenges associated NPC therapies. While potential promote neuroregeneration through various mechanisms, their low long-term survival integration within host injured limit functional benefits NPC-based address challenge, combinatorial strategies developed optimize outcomes by enriching microenvironment biomaterials, genetic pharmacological In review, we will provide in-depth discussion on recent advances We discuss modes actions mechanism which engrafted contribute repair process recovery. also update current clinical trials technologies that facilitated preparation medical-grade human suitable transplantation studies.
Language: Английский
Citations
40
Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 521 - 543
Published: May 30, 2024
Spinal cord injury (SCI) often results in irreversible loss of sensory and motor functions, most SCIs are incurable with current medical practice. One the hardest challenges treating SCI is development a dysfunctional pathological microenvironment, which mainly comprises excessive inflammation, deposition inhibitory molecules, neurotrophic factor deprivation, glial scar formation, imbalance vascular function. To overcome this challenge, implantation functional biomaterials at site has been regarded as potential treatment for modulating microenvironment to support axon regeneration, remyelination site, recovery after SCI. This review summarizes characteristics recent advances well technologies used modulate inflammatory regulate reshape revascularization microenvironment. Moreover, technological limitations, challenges, future prospects promote efficient repair also discussed. will aid further understanding
Language: Английский
Citations
11
ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 13333 - 13345
Published: May 8, 2024
A persistent inflammatory response, intrinsic limitations in axonal regenerative capacity, and widespread presence of extrinsic inhibitors impede the restoration motor function after a spinal cord injury (SCI). versatile treatment platform is urgently needed to address diverse clinical manifestations SCI. Herein, we present multifunctional nanoplatform with anisotropic bimodal mesopores for effective neural circuit reconstruction The hierarchical features Janus structure consist dual compartments hydrophilic mesoporous silica (mSiO2) hydrophobic periodic organosilica (PMO), each possessing distinct pore sizes 12 3 nm, respectively. Unlike traditional nanomaterials dual-mesopores interlaced other, two sets this are spatially independent possess completely chemical properties. facilitate controllable codelivery drugs properties: macromolecular enoxaparin (ENO) small molecular paclitaxel (PTX). Anchoring CeO2, resulting mSiO2&PMO-CeO2–PTX&ENO nanoformulation not only effectively alleviates ROS-induced neuronal apoptosis but also enhances microtubule stability promote regeneration facilitates extension by diminishing inhibitory effect extracellular chondroitin sulfate proteoglycans. We believe that functional dual-mesoporous holds significant potential combination therapy treating severe multifaceted diseases.
Language: Английский
Citations
5
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(3)
Published: Oct. 12, 2023
Abstract Biohybrid neural interfaces (BHNIs) are a new class of neuromodulating devices that integrate microelectrode arrays (MEAs) and cell transplantation to improve treatment nerve injuries disorders. However, current BHNI made from abiotic materials usually bio‐passive, non‐biodisintegratable, or rigid, which restricts encapsulated activity host reconstruction frequently leads local tissue inflammation. Herein, the first MEA composed all disintegratable hydrogel scaffold with synergistic performances conformal adhesiveness, technologies, scaffolding stem therapy on time scale appropriate for repair is proposed. In particular, conductive tracks extracellular matrix (ECM)‐based double‐cross‐linked dual‐electrically (ECH) systems robust tissue‐mimicking chemical/physical properties, electrical conductivity, an affinity progenitor cells. Meanwhile, substrate prepared transglutaminase‐incorporated gelatin/silk precursors simultaneously promotes gelation interfacial adhesion between stacks, leading rapid scalable device integration. When full subjected various mechanical stimuli moisture, it structurally stable low impedance (4 ± 3 kΩ) comparable recently reported benchmark. With seamless lamination around peripheral fibers, permits successive signal monitoring wound condition evaluation, while demonstrating effects spatiotemporally controlled stimulation accelerate restoration motor function. This completely degraded by 1 month thus eliminating need surgical retrieval stably remain, interact, further fuse tissues, successfully exhibiting compatible integration biology implanted system.
Language: Английский
Citations
10
Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106854 - 106854
Published: Feb. 1, 2025
Spinal cord injury (SCI) disrupts the communication between brain and spinal cord, resulting in loss of motor function below site. However, spontaneous structural functional plasticity occurs neural circuits after SCI, with unaffected synaptic inputs forming new connections detour pathways to support recovery. The review discusses various mechanisms circuit reorganization post-SCI, including supraspinal pathways, interneurons, central pattern generators. Functional recovery may rely on maintaining a balance excitatory inhibitory activity, as well enhancing proprioceptive input, which plays key role limb stability. emphasizes importance endogenous neuronal regeneration, neuromodulation therapies (such electrical stimulation) proprioception SCI treatment. Future research should integrate advanced technologies such gene targeting, imaging, single-cell mapping better understand underpinning recovery, aiming identify subpopulations for targeted reconstruction enhanced By harnessing reorganization, these efforts hold potential pave way more precise effective strategies SCI.
Language: Английский
Citations
0
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111087 - 111087
Published: March 1, 2025
Language: Английский
Citations
0
Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113842 - 113842
Published: March 1, 2025
Language: Английский
Citations
0
Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 347 - 347
Published: March 28, 2025
Objective: Because of the evolving nature tissue engineering scaffolds in treatment spinal cord injury (SCI), current study was carried out to evaluate research productivity SCI. Methods: Studies published from 2000 2025 were retrieved Web Science core collection with topics and scaffolds. The data analyzed visualized using VOSviewer network analysis software. Results: Among 1542 articles analyzed, annual publications surged 2019, stabilizing thereafter. U.S., China, Canada led productivity, Northwestern University Biomaterials journal being top contributors. Keyword revealed hotspots such as functional recovery, axonal regeneration, stem cells, hydrogels. Notably, hydrogels embedded genetically engineered cells emerged a pivotal trend, reflecting shift toward biomimetic combinatorial therapies. Collaboration networks highlighted intensified partnerships between Chinese North American institutions, signaling global interdisciplinary efforts. Conclusions: This provides first bibliometric roadmap for SCI, identifying key trends, influential entities, underexplored areas. rise international collaborations underscores opportunities targeted research. These findings guide researchers prioritizing high-impact journals, fostering partnerships, advancing novel scaffold designs bridge translational gaps SCI treatment.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162988 - 162988
Published: April 1, 2025
Language: Английский
Citations
0