Effect of hydrogel drug delivery system for treating ulcerative colitis: A preclinical meta-analysis DOI
Lan Jiang, J.W. Li,

Runkun Yang

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 659, P. 124281 - 124281

Published: May 25, 2024

Language: Английский

Dextran‐Based Antibacterial Hydrogel Dressings for Accelerating Infected Wound Healing by Reducing Inflammation Levels DOI

Jianhao Liang,

Junhong Ling,

Deguan Sun

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 27, 2024

Infected wounds pose challenges such as exudate management, bacterial infections, and persistent inflammation, making them a significant challenge for modern dressings. To address these issues in infected more effectively, aerogel-hydrogel biphase gels based on dextran are developed. The gel introduced this study exhibits antibacterial anti-inflammatory properties the process of wound therapy, contributing to accelerated healing. aerogel phase exceptional water-absorption capabilities, rapidly soaking up from wound, thereby fostering clean hygienic healing microenvironment. Concurrently, is enriched with hydrogen sulfide donors. Following water absorption formation hydrogel phase, it enables sustained release around sites. experiments confirm that sulfide, by promoting M2 macrophage differentiation reducing levels inflammatory factors, effectively diminishes local inflammation at site. Furthermore, sodium copper chlorophyllin component within demonstrates effective through photodynamic antimicrobial providing viable solution infection challenges.

Language: Английский

Citations

22
Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing DOI Creative Commons

Xuehao Tian,

Yuting Wen, Zhongxing Zhang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123134 - 123134

Published: Jan. 1, 2025

Language: Английский

Citations

4
Synergistic effects of pH and nano-calcium carbonate on sodium alginate gels and their application for encapsulation, protection, delivery and yoghurt of probiotics DOI Creative Commons
Kaili Wang, Xu Zhao,

Houyu Chi

et al.

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117385 - 117385

Published: Jan. 1, 2025

Language: Английский

Citations

2
Orally administered metal–organic framework nanocubes for sequence-targeted quercetin delivery in colitis alleviation DOI
Runan Zhao, Tao Chen, Shumeng Hu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160373 - 160373

Published: Feb. 1, 2025

Language: Английский

Citations

1
Local delivery of EGFR+NSCs-derived exosomes promotes neural regeneration post spinal cord injury via miR-34a-5p/HDAC6 pathway DOI Creative Commons
Tian Qin, Chengjun Li, Yan Xu

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 424 - 443

Published: Nov. 28, 2023

Spinal cord injury (SCI) causes severe axon damage, usually leading to permanent paraparesis, which still lacks effective regenerative therapy. Recent studies have suggested that exosomes derived from neural stem cells (NSCs) may hold promise as attractive candidates for SCI treatment. Epidermal Growth Factor Receptor positive NSC (EGFR+NSC) is a subpopulation of endogenous NSCs, showing strong capability in central nervous system disease. In the current study, we isolated EGFR+NSCs (EGFR+NSCs-Exos) and discovered local delivery EGFR+NSCs-Exos can effectively promote neurite regrowth site spinal cord-injured mice improve their neurological function recovery. Using miRNA-seq, firstly characterized microRNAs (miRNAs) cargo identified miR-34a-5p was highly enriched exosomes. We further interpreted exosomal could be transferred neurons inhibit HDAC6 expression by directly binding its mRNA, contributing microtubule stabilization autophagy induction aiding repair. Overall, our research demonstrated novel therapeutic approach improving functional recovery using secreted NSCs providing precise cell-free treatment strategy

Language: Английский

Citations

18
Macrostructure and Microenvironment Biomimetic Hydrogel: Design, Properties, and Tissue Engineering Application DOI

Shufeng Hu,

Chen Zeng, Yuchen Jiang

et al.

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(3), P. 1054 - 1087

Published: Jan. 16, 2024

The field of tissue engineering and regenerative medicine is rapidly advancing, with numerous novel intriguing biomimetic materials being reported. Hydrogels, due to their unique structure properties closely resembling biological tissues, stand as prime candidates for mimicking natural tissues in applications. In recent years, drawing inspiration from the intricate structures found soft researchers have successfully created a range hydrogels. These hydrogels been tailored diverse applications fields such biomedicine, engineering, flexible electronic devices, beyond. However, designing fabricating synthetic structures, dynamic microenvironment systems, integrated functionalities remains challenging. This article presents latest research progress macroscopic structural hydrogels, well along most construction strategies, key design principles, optimization mechanisms. It summarizes potential various domains repair, signal detection sensing, drug delivery, more. Lastly, challenges future development directions preparation application are outlined.

Language: Английский

Citations

8
An Octopus‐Inspired Stimulus‐Responsive Structural Color Hydrogel for Uterus Cervical Canal Stent DOI

Lihao Zhang,

Lehao Ren,

Yufei Chen

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: June 13, 2024

Abstract Soft‐bodied aquatic organisms have exhibited remarkable capabilities in navigating and moving within liquid environments serving as a profound inspiration for the development of bionic robots with intricate movements. Traditional rigid components are being replaced by stimulus‐responsive soft materials such hydrogels shape memory polymers, leading to creation dynamically responsive robots. In this study, robot inspired an octopus adsorptive properties its tentacles, specifically tailored targeted stimulation pH sensing cervix, presented. This approach involves design soft, water‐based Janus adhesive hydrogel patch that adheres specific parts cervix responds changes through external stimuli. The incorporates inverse opal microstructures mimicking legs octopus, facilitate efficient stable locomotion, unidirectional transport biofluids, pH‐responsive behavior. miniature showcases controlled adhesion precise fluid highlighting potential stimulus response uterine cervical tract. breakthrough opens new avenues medical applications expanding field soft‐bodied robotics.

Language: Английский

Citations

6
Β-Cyclodextrin-based materials for 3D printing, cancer therapy, tissue engineering, and wound healing DOI
Malairaj Sathuvan, Sunhong Min, Karthikeyan Narayanan

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157272 - 157272

Published: Oct. 1, 2024

Language: Английский

Citations

5
Tannic acid-based metal-phenolic networks as a versatile platform to mediate cell therapy DOI
Huilong Luo, Juan Xie,

Xiao-Yong Su

et al.

Science China Materials, Journal Year: 2024, Volume and Issue: 67(12), P. 3833 - 3848

Published: Nov. 7, 2024

Language: Английский

Citations

5
Fecal microbiota transplantation alleviates experimental colitis through the Toll-like receptor 4 signaling pathway DOI Creative Commons
Xin Wen, Rui Xie, Honggang Wang

et al.

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(30), P. 4657 - 4670

Published: Aug. 9, 2023

Fecal microbiota transplantation (FMT) has shown promising therapeutic effects on mice with experimental colitis and patients ulcerative (UC). FMT modulates the Toll-like receptor 4 (TLR4) signaling pathway to treat some other diseases. However, it remains unknown whether this modulation is also involved in treatment of UC.To clarify necessity TLR4 dextran sodium sulphate (DSS)-induced explain mechanism UC, through association analysis gut colon transcriptome mice.A mouse model was constructed wild-type (WT) TLR4-knockout (KO) mice. transplanted by gavage. Colon inflammation severity measured disease activity index (DAI) scoring hematoxylin eosin staining. Gut structure analyzed 16S ribosomal RNA sequencing. Gene expression obtained sequencing.The KO (DSS + Water) FMT) groups displayed indistinguishable body weight loss, length, DAI score, histology which showed that could not inhibit In treated FMT, relative abundance Akkermansia decreased, Lactobacillus became dominant. particular, compared those WT mice, scores were clearly decreased KO-DSS group. Microbiota a significant difference between dominant genus healthy The ineffectiveness related Akkermansia. Ontology enrichment differentially expressed genes each group mainly cytoplasmic translation cellular response DNA damage stimulus. top nine correlating included Aqp4, Clca4a, Dpm3, Fau, Mcrip1, Meis3, Nupr1 L, Pank3, Rps13 (|R| > 0.9, P < 0.01).FMT may ameliorate DSS-induced regulating pathway. composition maintain stability intestinal environment. bear great potential for colitis.

Language: Английский

Citations

13