Hydrogel-based Cardiac Patches for Myocardial Infarction Therapy: Recent Advances and Challenges DOI Creative Commons
Zhenqiu Liu, Zhi Zheng,

Jiahao Xie

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101331 - 101331

Published: Nov. 7, 2024

Myocardial infarction (MI) remains the leading cause of death related to cardiovascular diseases globally, presenting a significant clinical challenge due specificity lesion site and limited proliferative capacity cardiomyocytes (CMs) for repairing infarcted myocardium. Extensive studies reported so far has focused on utilization hydrogel-based cardiac patches MI treatment, highlighting their promising mechanical properties, conductivity, ability remodel microenvironment post-repair. However, majority developed have been myocardial tissue surface via suturing or adhesive administration. Suturing inevitably leads additional damage fragile myocardium, while uneven application adhesives may result in patch displacement compromised drug release. Based these critical issues, we systematically summarize advantages drawbacks using hydrogel treatment with emphasis elucidating various design strategies. Specifically, first describe changes pathological following MI. Next, discuss biomimetic types patches, functional design, corresponding strategies adaptation, emphasizing adhesion mechanisms, wet strategies, fabrication techniques patches. Finally, address potential challenges prospects hydrogels as therapy. The review is believed provide theoretical guidance development new therapeutic effectively treatment.

Language: Английский

Synthesis of PVA-Based Hydrogels for Biomedical Applications: Recent Trends and Advances DOI Creative Commons
Mohammad Mizanur Rahman Khan, Md. Mahamudul Hasan Rumon

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 88 - 88

Published: Jan. 23, 2025

There is ongoing research for biomedical applications of polyvinyl alcohol (PVA)-based hydrogels; however, the execution this has not yet been achieved at an appropriate level commercialization. Advanced perception necessary design and synthesis suitable materials, such as PVA-based hydrogel applications. Among polymers, drawn great interest in owing to their attractive potential with characteristics good biocompatibility, mechanical strength, apposite water content. By designing approach investigating structure, hydrogels can attain superb cytocompatibility, flexibility, antimicrobial activities, signifying that it a candidate tissue engineering regenerative medicine, drug delivery, wound dressing, contact lenses, other fields. In review, we highlight current progresses on explaining diverse usage across variety areas. We explain numerous techniques related phenomena based these materials. This review may stipulate wide reference future acumens materials extensive

Language: Английский

Citations

2
A collagen/nanocellulose/lignin hydrogel dressing mimicking to the plant cell wall for enhanced wound healing and bacterial inhibition DOI Creative Commons
Xin Li,

Chen Rui-ying,

Xueyu Tang

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 228, P. 120872 - 120872

Published: March 23, 2025

Language: Английский

Citations

0
Current Status of Research on Biomimetic Hydrogels for Articular Cartilage DOI

Kuishun Ma,

Fei Wang,

Tingxin Liang

et al.

Journal of Bionic Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
Injectable, self-healing and degradable dynamic hydrogels with tunable mechanical properties and stability by thermal-induced micellization DOI Creative Commons

Chunqing Lin,

Leniu Chen,

Yuan He

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(23), P. 16207 - 16217

Published: Jan. 1, 2024

Dynamic hydrogels were created based on ABA triblock copolymers with acylhydrazone bonds crosslinking. The displayed injectability, self-healing and biocompatibility. And their mechanics stability could be tuned by temperature.

Language: Английский

Citations

2
Smart hydrogel-based trends in future tendon injury repair: A review DOI
Yingxue Jiang, Chenhui Zhu,

Xiaoxuan Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137092 - 137092

Published: Nov. 1, 2024

Language: Английский

Citations

2
Biocompatible dually reinforced gellan gum hydrogels with selective antibacterial activity DOI

X. D. Jin,

Cuicui Wang,

Zhaolong Sun

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 351, P. 123071 - 123071

Published: Nov. 28, 2024

Language: Английский

Citations

1
Iron Nano Biocomposite-Infused Biopolymeric Films: A Multifunctional Approach for Robust Skin Repair DOI
Akshant Kumawat,

Srusti Dave,

Sophia Varghese

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(24), P. 30819 - 30832

Published: June 7, 2024

Sodium alginate (SA) biopolymeric films have various limitations such as poor mechanical properties, high vapor permeability, lack of antibacterial activity, excessive burst release, and weak cell adhesion. To overcome these limitations, a strategy involving the integration nanofillers into an SA film matrix is explored. In this context, cost-effective iron-containing carbon nano biocomposite (FeCNB) nanofiller developed using solvent-free technique. This nanocomposite successfully incorporated at varying concentrations (0.05, 0.1, 0.15%) aimed enhancing its physicochemical biological properties for biomedical applications. Characterization through FESEM BET analyses confirms porous nature FeCNB. EDX shows FeCNB's uniform distribution upon matrix, albeit without strong chemical interaction with SA. Instead, hydrogen bonding interactions become apparent in FTIR spectra. By incorporating FeCNB, attributes are improved water permeability approaches desired range (2000–2500 g/m2day). The film's swelling ratio reduction contributes to decrease permeability. activity sustained release property FeCNB-incorporated established tetracycline hydrochloride (TCl), model drug. drug profile resembled Korsmeyer-Peppas's pattern. vitro assessments via MTT assay scratch on NIH-3T3 cells reveal that FeCNB has no adverse effects biocompatibility films. proliferation adhesion significantly enhanced after infusion vivo study performed rat demonstrates wound healing by FeCNB-impregnated Based comprehensive findings, proposed prove be promising candidate robust skin repair.

Language: Английский

Citations

0
Hydrogel-based Cardiac Patches for Myocardial Infarction Therapy: Recent Advances and Challenges DOI Creative Commons
Zhenqiu Liu, Zhi Zheng,

Jiahao Xie

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101331 - 101331

Published: Nov. 7, 2024

Myocardial infarction (MI) remains the leading cause of death related to cardiovascular diseases globally, presenting a significant clinical challenge due specificity lesion site and limited proliferative capacity cardiomyocytes (CMs) for repairing infarcted myocardium. Extensive studies reported so far has focused on utilization hydrogel-based cardiac patches MI treatment, highlighting their promising mechanical properties, conductivity, ability remodel microenvironment post-repair. However, majority developed have been myocardial tissue surface via suturing or adhesive administration. Suturing inevitably leads additional damage fragile myocardium, while uneven application adhesives may result in patch displacement compromised drug release. Based these critical issues, we systematically summarize advantages drawbacks using hydrogel treatment with emphasis elucidating various design strategies. Specifically, first describe changes pathological following MI. Next, discuss biomimetic types patches, functional design, corresponding strategies adaptation, emphasizing adhesion mechanisms, wet strategies, fabrication techniques patches. Finally, address potential challenges prospects hydrogels as therapy. The review is believed provide theoretical guidance development new therapeutic effectively treatment.

Language: Английский

Citations

0