Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Abstract
With
the
improvement
of
implant
design
and
expansion
application
scenarios,
orthopedic
implants
have
become
a
common
surgical
option
for
treating
fractures
end‐stage
osteoarthritis.
Their
goal
is
rapidly
forming
long‐term
stable
osseointegration.
However,
this
fixation
effect
limited
by
surface
characteristics
peri‐implant
bone
tissue
activity.
Therefore,
review
summarizes
strategies
interface
engineering
(osteogenic
peptides,
growth
factors,
metal
ions)
treatment
methods
(porous
nanotubes,
hydrogel
embedding,
other
load‐release
systems)
through
research
on
its
biological
mechanism,
paving
way
to
achieve
adaptation
both
coordination
between
different
strategies.
transition
osseointegration
stage,
demonstrated
varying
therapeutic
effects.
Especially,
activity
osteoblasts
runs
almost
entire
process
osseointegration,
their
physiological
activities
play
dominant
role
in
formation.
Furthermore,
diseases
impacting
metabolism
exacerbate
difficulty
achieving
This
aims
assist
future
improve
implant‐bone
fixation,
promote
fracture
healing,
enhance
post‐implantation
recovery.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 16, 2024
Abstract
The
catalytic
therapy
for
abundant
•OH,
1
O
2
,
and
•O
−
provides
an
efficient
tactic
methodology
rapid
tumor/bacteria
killing,
whereas
the
limitation
is
focused
on
efficiency
owing
to
in‐built
energy
band
of
materials.
Thus,
d‐band
center
tuning
BioHJzyme
devised,
which
composed
zinc
tellurate/manganese
dioxide
anchored
by
glucose
oxidase
(GOx)
with
anti‐tumor
anti‐bacteria
properties
postoperative
infected
wound
regeneration
tumor.
GOx
depletes
produce
H
intercepting
metabolism.
D‐BioHJzyme
can
catalyze
produced
highly
lethal
•OH
POD‐mimetic
activity
tunned
strategy
decreasing
adsorption
intermediate
in
catalytical
process,
while
oxygen
originated
from
Mn
2+
be
catalyzed
into
.
GPx‐mimetic
it
impair
antioxidant
system
In
vivo
studies
show
that
exhibits
robust
abilities
against
bacteria
tumors
•OH/
production
promotes
apoptosis
Te.
Besides,
accelerate
cutaneous
M1/M2
regulation
angiogenesis/collagen
deposition.
This
work
enlightens
a
powerful
platform
remedy
tumor
resection
using
engineered
BioHJzyme.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Abstract
With
the
improvement
of
implant
design
and
expansion
application
scenarios,
orthopedic
implants
have
become
a
common
surgical
option
for
treating
fractures
end‐stage
osteoarthritis.
Their
goal
is
rapidly
forming
long‐term
stable
osseointegration.
However,
this
fixation
effect
limited
by
surface
characteristics
peri‐implant
bone
tissue
activity.
Therefore,
review
summarizes
strategies
interface
engineering
(osteogenic
peptides,
growth
factors,
metal
ions)
treatment
methods
(porous
nanotubes,
hydrogel
embedding,
other
load‐release
systems)
through
research
on
its
biological
mechanism,
paving
way
to
achieve
adaptation
both
coordination
between
different
strategies.
transition
osseointegration
stage,
demonstrated
varying
therapeutic
effects.
Especially,
activity
osteoblasts
runs
almost
entire
process
osseointegration,
their
physiological
activities
play
dominant
role
in
formation.
Furthermore,
diseases
impacting
metabolism
exacerbate
difficulty
achieving
This
aims
assist
future
improve
implant‐bone
fixation,
promote
fracture
healing,
enhance
post‐implantation
recovery.
