Enzalutamide inhibits PEX10 function and sensitizes prostate cancer cells to ROS activators DOI Creative Commons
Yuankang Feng, Yu Zhang, Hao Li

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(8)

Published: Aug. 3, 2024

Sharply increased reactive oxygen species (ROS) are thought to induce oxidative stress, damage cell structure and cause death; however, its role in prostate cancer remains unclear. Enzalutamide is a widely used anti-prostate drug that antagonizes androgen binding with receptor. Further exploration of the mechanism potential application strategies enzalutamide crucial for treatment cancer. Here, we confirmed PEX10 can be induced by ROS activators while reduce level cells, which weakened anti-tumor effect activators. The receptor (AR) promote expression acting as an enhancer cooperation FOXA1. inhibits inhibiting function AR, synergize ML210 or RSL3 produce stronger effect, thereby sensitizing cells This study reveals previously unrecognized AR regulating suggests new strategy treatment.

Language: Английский

A Tumor-Homing Nanoframework for Synergistic Microwave Tumor Ablation and Provoking Strong Anticancer Immunity Against Metastasis DOI

Xueqing Cheng,

Chuanshi He,

Jiangbo Huang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(42), P. 29121 - 29139

Published: Oct. 10, 2024

Microwave thermotherapy (MT) is a clinical local tumor ablation modality, but its applications are limited by therapeutic efficacy and safety. Therefore, developing sensitizers to optimize the outcomes of MT in demand practice. Herein, we engineered special nanoframework (i.e., FdMI) based on fucoidan-decorated zirconium metal-organic framework incorporating manganese ions liquid physisorption for microwave ablation. The monodisperse exhibited both thermal effects dynamic effects, which could effectively kill cancer cells efficient intracellular drug delivery. Through fucoidan-mediated targeting P-selectin microenvironment (TME), FdMI accumulated regions, leading significant eradication orthotropic triple-negative breast (TNBC) aggressive Hepa1-6 liver tumors synergistic thermotherapy/dynamic therapy (MT/MDT). primary activate systemic immune responses, inhibited distant TNBC lung metastasis tumors, respectively. This work not only nanoparticle tumor-targeted MT/MDT also demonstrated that nanocarrier-based stimulate antitumor immunity inhibit metastatic demonstrating high potential managing advanced malignant tumors.

Language: Английский

Citations

2
Engineered Microalgae for Photo-Sonodynamic Synergistic Therapy in Breast Cancer Treatment DOI

Chaoli Xu,

Jiahong Dong,

Xuzhi Shi

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

2
The effect of partial replacement of calf fat and canola oil instead of dietary fish oil on growth performance, liver tissue, liver enzymes and chemical composition of young rainbow trout (Oncorhynchus mykiss) DOI Creative Commons

Hamid Jafarnodeh,

Afshin Ghelichi,

S Jorjani

et al.

Aquaculture Reports, Journal Year: 2024, Volume and Issue: 36, P. 102097 - 102097

Published: April 24, 2024

Language: Английский

Citations

1
Electrodynamic therapy: Novel nanodynamic strategy for anticancer and anti-infection therapy DOI
Wenxin Liu, Ning Wu,

Jinze Song

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 494, P. 152882 - 152882

Published: June 5, 2024

Language: Английский

Citations

1
Enzalutamide inhibits PEX10 function and sensitizes prostate cancer cells to ROS activators DOI Creative Commons
Yuankang Feng, Yu Zhang, Hao Li

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(8)

Published: Aug. 3, 2024

Sharply increased reactive oxygen species (ROS) are thought to induce oxidative stress, damage cell structure and cause death; however, its role in prostate cancer remains unclear. Enzalutamide is a widely used anti-prostate drug that antagonizes androgen binding with receptor. Further exploration of the mechanism potential application strategies enzalutamide crucial for treatment cancer. Here, we confirmed PEX10 can be induced by ROS activators while reduce level cells, which weakened anti-tumor effect activators. The receptor (AR) promote expression acting as an enhancer cooperation FOXA1. inhibits inhibiting function AR, synergize ML210 or RSL3 produce stronger effect, thereby sensitizing cells This study reveals previously unrecognized AR regulating suggests new strategy treatment.

Language: Английский

Citations

1