Amplifying Synergistic Effects of Cuproptosis and Bacterial Membrane Vesicles‐Mediated Photothermal Therapy by Multifunctional Nano‐Biohybrid for Anti‐Tumor Immunotherapy DOI Open Access

Mei‐Ting Niu,

Qian‐Ru Li,

Qian‐Xiao Huang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract The other functions of bacterial membrane vesicles (BMVs) except serving as immune adjuvants and vaccine platforms are yet to be further explored. This study investigates the photothermal properties Rhodobacter sphaeroides‐derived BMVs (RMVs) beyond their immunostimulatory properties. A multifunctional nano‐biohybrid, termed CuM@RR, is constructed by encapsulating Cu‐based metal–organic framework (CuM) nanoparticles into DSPE‐PEG 2000 ‐RGD‐functionalized RMVs, leveraging functionalization cargo capacity BMVs. ‐RGD modification facilitates targeted delivery CuM@RR tumor sites. CuM core within decomposes in acid microenvironment, releasing Cu 2+ inducing cell cuproptosis. Under 808 nm near‐infrared irradiation, effect‐induced apoptosis synergizes with copper ions overload‐induced cuproptosis, causing irreversible mitochondrial damage cells triggering strong immunogenic death (ICD). released damage‐associated molecular patterns (DAMPs) tumor‐associated antigens (TAAs) during ICD, along inherent immunoadjuvant elicit robust anti‐tumor responses. In vivo experiments confirm that significantly suppresses growth prevents rechallenge without obvious systemic toxicity under synergistic effects therapy, immunotherapy, suggesting great potential this nano‐biohybrid developing safe effective multi‐therapeutic strategies.

Language: Английский

Copper-Based Nanomaterials for Image-Guided Cancer Therapy DOI Creative Commons
Haonan Xu,

Zhili Guo,

Mingjie Li

et al.

BIO Integration, Journal Year: 2024, Volume and Issue: 5(1)

Published: Jan. 1, 2024

Abstract Cancer is a significant disease that poses major threat to human health. Image-guided cancer therapy refers series of medical procedures use imaging technology precisely locate and treat cancer. Combining the dual characteristics images functional nanomaterial (NM) drug carriers, various integrated diagnosis treatment probes have been developed for in vivo dynamic monitoring therapeutic effect evaluation drugs based on imaging. Copper (Cu)-based NMs emerged as valuable products nanotechnology due their unique physicochemical properties, which are influenced by factors, such size, shape, surface properties. In field imaging, Cu-based offer combination desirable characteristics, including fluorescence emission, contrast enhancement, radiolabeling stability. These properties form foundation wide range modalities. addition, can be used carrier diagnostic or synergistic multiple modalities realized doping transition metals into heterostructures. become an important basis imaging-guided with NMs. this review we introduce biocompatible image-guided provide overview promising outcomes biomedical research.

Language: Английский

Citations

5
Hollow Calcium/Copper Bimetallic Amplifier for Cuproptosis/Paraptosis/Apoptosis Cancer Therapy via Cascade Reinforcement of Endoplasmic Reticulum Stress and Mitochondrial Dysfunction DOI
Weijun Xu,

Aili Suo,

Abdalrheem Jarelnaby Musa Aldai

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 30053 - 30068

Published: Oct. 16, 2024

The endoplasmic reticulum (ER) and mitochondria are essential organelles that play crucial roles in maintaining cellular homeostasis. simultaneous induction of ER stress mitochondrial dysfunction represents a promising yet challenging strategy for cancer treatment. Herein, hollow calcium–copper bimetallic nanoplatform is developed as cascade amplifier to reinforce breast For this purpose, we report facile method preparing CaCO3 (HCC) nanoparticles by regulating the dissolution–recrystallization process amorphous CaCO3, D@HCC-CuTH meticulously fabricated sequentially coating disulfiram-loaded HCC with copper coordination polymer hyaluronan. In tumor cells, dithiocarbamate–copper complex generated situ liberated disulfiram Cu2+ inhibits ubiquitin–proteasome system, causing irreversible intracellular Ca2+ redistribution. Meanwhile, induces via triggering self-amplifying loop burst, reactive oxygen species augment. Additionally, dihydrolipoamide S-acetyltransferase oligomerization mitochondria, further exacerbating damage cuproptosis. Collectively, amplification synergistically induce cuproptosis–paraptosis–apoptosis trimodal cell death pathway, which demonstrates significant efficacy suppressing growth. This study presents paradigm synchronously inducing subcellular organelle disorders boost multimodal therapy.

Language: Английский

Citations

5
Targeting the initiator to activate both ferroptosis and cuproptosis for breast cancer treatment: progress and possibility for clinical application DOI Creative Commons

Murshid Imam,

Jiale Ji,

Zhijie Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

Breast cancer is the most commonly diagnosed worldwide. Metal metabolism pivotal for regulating cell fate and drug sensitivity in breast cancer. Iron copper are essential metal ions critical maintaining cellular function. The accumulation of iron triggers distinct death pathways, known as ferroptosis cuproptosis, respectively. Ferroptosis characterized by iron-dependent lipid peroxidation, while cuproptosis involves copper-induced oxidative stress. They increasingly recognized promising targets development anticancer drugs. Recently, compelling evidence demonstrated that interplay between plays a crucial role progression. This review elucidates converging pathways Moreover, we examined value genes associated with clinical diagnosis treatment cancer, mainly outlining potential co-targeting approach. Lastly, delve into current challenges limitations this strategy. In general, offers an overview interaction offering valuable perspectives further research treatment.

Language: Английский

Citations

0
Nanotechnology for cancer immunotherapy DOI

Xiaoqi Zheng,

Bella B. Manshian, Stefaan J. Soenen

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Immunogenic Cuproptosis in Cancer Immunotherapy via an In Situ Cuproptosis-Inducing System DOI Creative Commons
Jiehan Li, Ge Zhang, Kai Zhao

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123201 - 123201

Published: Feb. 20, 2025

Language: Английский

Citations

0
Nanomaterial‐Triggered Ferroptosis and Cuproptosis in Cancer Therapy DOI
Suman Sekhar Sahoo, Debasish Manna

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Cancer remains one of the leading causes death individuals globally. Conventional treatment techniques like chemotherapy and radiation often suffer various drawbacks toxicity drug resistance. The study cell has been predominantly focused on classical forms apoptosis, but role metal ions in governing controlled is a fascinating less explored area. Metal‐mediated process where triggers via unique mechanism. Nanomaterial‐based strategies have gained attention for their ability to deliver precise therapeutic agents while also triggering Regulated Cell Death (RCD) mechanisms cancer cells. recently discovered metal‐mediated cuproptosis ferroptosis can be used as they selectively drug‐resistant cancer. Nano material‐based delivery system targeted sites. In this review, we given some idea about mechanism (ferroptosis cuproptosis) how initiate deaths using nanomaterials treatment.

Language: Английский

Citations

0
A heterojunction-engineering nanodrug with tumor microenvironment responsiveness for tumor-specific cuproptosis and chemotherapy amplified sono-immunotherapy DOI
Yang Wang, Tingting Yan, Jinming Cai

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 321, P. 123319 - 123319

Published: April 4, 2025

Language: Английский

Citations

0
Recent Advances and Future Prospects in Biological-Membrane-Targeted Polymers DOI Creative Commons
Ran Chen, Yaping Liu, Yanan Jiang

et al.

Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

Citations

0
A Diketopyrrolopyrrole‐Based All‐in‐One Nanoplatform for Self‐Reinforcing Mild Photothermal Therapy Cascade Immunotherapy for Tumors DOI
Xinsheng Li, Lingyan Liu,

Kaini Yang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: July 15, 2024

Abstract Mild photothermal therapy (PTT) has attracted attention for effectively avoiding the severe side effects associated with high‐temperature tumor ablation. However, its progress is hindered by limited availability of high‐performance agents (PTAs) and thermoresistance cancer cells induced heat shock reactions. Herein, this work proposes a new strategy to expand library organic small‐molecule PTAs utilize it construct multifunctional nano‐theranostic platform. By incorporating additional acceptors appropriate π‐bridges, diketopyrrolopyrrole‐based dye BDB developed, which exhibits strong absorption bright fluorescence emission in near‐infrared (NIR) region. Subsequently, co‐coated protein (HSP) inhibitor tanespimycin (17‐AAG) using functional amphiphilic polymers DSPE‐Hyd‐PEG 2000 ‐cRGD form an all‐in‐one nanoplatform BAG NPs. As result, NPs can precisely target tissue, guide treatment process real‐time through NIR‐II fluorescence/photoacoustic/photothermal imaging, release 17‐AAG on demand enhance mild PTT. Additionally, PTT been demonstrated induce immunogenic cell death (ICD) activate systemic anti‐tumor immune response, thereby suppressing both primary distant tumors. Overall, study presents designed precise combined immunotherapy effective treatment.

Language: Английский

Citations

3
Nanomaterials: leading immunogenic cell death-based cancer therapies DOI Creative Commons

Changyu Ma,

Zhe Cheng, Haotian Tan

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 9, 2024

The field of oncology has transformed in recent years, with treatments shifting from traditional surgical resection and radiation therapy to more diverse customized approaches, one which is immunotherapy. ICD (immunogenic cell death) belongs a class regulatory death modalities that reactivate the immune response by facilitating interaction between apoptotic cells releasing specific signaling molecules, DAMPs (damage-associated molecular patterns). inducers can elevate expression proteins optimize TME (tumor microenvironment). use nanotechnology shown its unique potential. Nanomaterials, due their tunability, targeting, biocompatibility, have become powerful tools for drug delivery, immunomodulators, etc., significant efficacy clinical trials. In particular, these nanomaterials effectively activate ICD, trigger potent anti-tumor response, maintain long-term tumor suppression. Different types nanomaterials, such as biological membrane-modified nanoparticles, self-assembled nanostructures, metallic mesoporous materials, hydrogels, play respective roles induction structures mechanisms action. Therefore, this review will explore latest advances application common discuss how they provide new strategies cancer therapy. By gaining deeper understanding mechanism action researchers develop precise effective therapeutic approaches improve prognosis quality life patients. Moreover, hold promise overcome resistance conventional therapies, minimize side effects, lead personalized treatment regimens, ultimately benefiting treatment.

Language: Английский

Citations

3