Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
The
other
functions
of
bacterial
membrane
vesicles
(BMVs)
except
serving
as
immune
adjuvants
and
vaccine
platforms
are
yet
to
be
further
explored.
This
study
investigates
the
photothermal
properties
Rhodobacter
sphaeroides‐derived
BMVs
(RMVs)
beyond
their
immunostimulatory
properties.
A
multifunctional
nano‐biohybrid,
termed
CuM@RR,
is
constructed
by
encapsulating
Cu‐based
metal–organic
framework
(CuM)
nanoparticles
into
DSPE‐PEG
2000
‐RGD‐functionalized
RMVs,
leveraging
functionalization
cargo
capacity
BMVs.
‐RGD
modification
facilitates
targeted
delivery
CuM@RR
tumor
sites.
CuM
core
within
decomposes
in
acid
microenvironment,
releasing
Cu
2+
inducing
cell
cuproptosis.
Under
808
nm
near‐infrared
irradiation,
effect‐induced
apoptosis
synergizes
with
copper
ions
overload‐induced
cuproptosis,
causing
irreversible
mitochondrial
damage
cells
triggering
strong
immunogenic
death
(ICD).
released
damage‐associated
molecular
patterns
(DAMPs)
tumor‐associated
antigens
(TAAs)
during
ICD,
along
inherent
immunoadjuvant
elicit
robust
anti‐tumor
responses.
In
vivo
experiments
confirm
that
significantly
suppresses
growth
prevents
rechallenge
without
obvious
systemic
toxicity
under
synergistic
effects
therapy,
immunotherapy,
suggesting
great
potential
this
nano‐biohybrid
developing
safe
effective
multi‐therapeutic
strategies.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 13, 2024
Abstract
As
an
intracellular
protective
mechanism,
autophagy
has
the
potential
to
significantly
impair
therapeutic
effects
of
photothermal
therapy
(PTT)
and
chemodynamic
(CDT),
which
helps
cancer
cells
survive
under
harsh
conditions,
such
as
high
temperature
reactive
oxygen
species
(ROS).
In
this
study,
blockage
enhanced
PTT
CDT
synergistic
nanoplatform
is
constructed
by
loading
hydroxychloroquine
(HCQ)
with
inhibitory
effect
into
hollow
copper
sulfide
(HCuS).
Specifically,
HCuS
produces
toxic
ROS
through
Fenton‐like
reaction
in
tumor
microenvironment
(TME).
At
same
time,
PTT‐mediated
elevation
region
accelerates
production,
enhancing
CDT.
Furthermore,
internal
inhibitor
HCQ
blocks
fusion
autophagosomes
lysosomes
deacidifying
lysosomes,
cutting
off
self‐protection
mechanism
cells,
amplifying
combined
treatment
Both
vitro
vivo
results
demonstrate
that
combination
photothermal‐enhanced
inhibition
provides
new
insights
designing
multifunctional
nanoagents.
ChemMedChem,
Journal Year:
2024,
Volume and Issue:
19(21)
Published: June 29, 2024
Abstract
Copper,
as
an
essential
trace
nutrient
for
human,
plays
a
crucial
role
in
numerous
cellular
activities,
and
is
vital
maintaining
homeostasis
organisms.
Deviations
from
normal
intracellular
copper
concentration
range
can
disrupt
the
lead
to
cell
death.
Cell
death
process
which
cells
lose
their
vitality
cannot
sustain
metabolism,
has
various
forms.
The
recently
discovered
cuproptosis
mechanism
differs
previously
recognized
forms,
triggered
by
accumulation.
discovery
of
sparked
interest
among
researchers,
this
been
applied
treatment
intractable
diseases,
including
different
types
cancer.
However,
developed
cuproptosis‐based
therapies
have
revealed
certain
limitations,
such
low
immunostimulatory
efficiency,
poor
tumor
targeting,
inhibition
microenvironment.
Therefore,
researchers
are
devoted
combining
with
existing
cancer
develop
more
effective
synergistic
therapies.
This
review
summarizes
latest
research
advancements
cancer,
focus
on
Finally,
it
provides
outlook
future
development
anti‐tumor
therapy.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Abstract
Photothermal
hydrogels
(PTHs)
are
considered
next‐generation
biomaterials
as
they
offer
remotely
defined
biophysical
information
of
the
extracellular
milieu.
PTHs
allow
precise
and
non‐genetic
control
for
regeneration
native
tissues,
which
is
ultimate
goal
tissue
engineering
(TE).
Molecular
physical
properties
PTHs,
such
components,
structural
configurations,
mechanical
characteristics,
collectively
serve
determinants
understanding
dynamic
response
clinical
translation.
have
entered
a
period
fruition
due
to
development
numerous
manufacturing
technologies
polymeric
matrices.
Herein,
this
review
comprehensively
meticulously
elucidates
mechanisms
regenerative
therapeutics
underlying
design
fabrication
PTHs.
Recent
advances
in
photothermal
principles
various
categories
agents
(PTAs)
been
extensively
discussed.
Vital
components
structures
summarized
enable
efficacious
therapeutic
energy
delivery.
Emerging
applications
TE
also
demonstrated,
expand
strategies
intrinsic
injured
tissues.
Then
deliberate
chemical
enhance
prognosis
while
highlighting
challenges
associated
with
In
review,
we
aim
provide
guidance
prospects
exploration
innovation
field
TE.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
The
other
functions
of
bacterial
membrane
vesicles
(BMVs)
except
serving
as
immune
adjuvants
and
vaccine
platforms
are
yet
to
be
further
explored.
This
study
investigates
the
photothermal
properties
Rhodobacter
sphaeroides‐derived
BMVs
(RMVs)
beyond
their
immunostimulatory
properties.
A
multifunctional
nano‐biohybrid,
termed
CuM@RR,
is
constructed
by
encapsulating
Cu‐based
metal–organic
framework
(CuM)
nanoparticles
into
DSPE‐PEG
2000
‐RGD‐functionalized
RMVs,
leveraging
functionalization
cargo
capacity
BMVs.
‐RGD
modification
facilitates
targeted
delivery
CuM@RR
tumor
sites.
CuM
core
within
decomposes
in
acid
microenvironment,
releasing
Cu
2+
inducing
cell
cuproptosis.
Under
808
nm
near‐infrared
irradiation,
effect‐induced
apoptosis
synergizes
with
copper
ions
overload‐induced
cuproptosis,
causing
irreversible
mitochondrial
damage
cells
triggering
strong
immunogenic
death
(ICD).
released
damage‐associated
molecular
patterns
(DAMPs)
tumor‐associated
antigens
(TAAs)
during
ICD,
along
inherent
immunoadjuvant
elicit
robust
anti‐tumor
responses.
In
vivo
experiments
confirm
that
significantly
suppresses
growth
prevents
rechallenge
without
obvious
systemic
toxicity
under
synergistic
effects
therapy,
immunotherapy,
suggesting
great
potential
this
nano‐biohybrid
developing
safe
effective
multi‐therapeutic
strategies.
