Nanomaterial‐Mediated Modulation of TRPV1 Ion Channels for Biomedical Applications DOI

Peng Pei,

Yafei Du,

Jiong‐Wei Wang

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cation channel involved in various physiological processes such as pain perception, thermoregulation, and inflammatory responses. Nanomaterials have emerged precise tools to modulate TRPV1 activity, offering high spatiotemporal resolution specificity. These nanomaterials act transducers, responding internal or external stimuli pH, light, electric, magnetic fields deliver modulatory agents like agonists, antagonists, heat, reactive species, mechanical forces channels. This strategy enables non‐invasive targeted therapeutic interventions for diseases associated with dysfunction. In this review, recent advances are highlighted nanomaterial‐mediated modulation its biomedical applications. The structure activation mechanisms, the integration of effective modulation, required material properties covered. Moreover, applications discussed, including neurostimulation, neurological disorder therapies, cancer metabolic disease treatments, cardiovascular interventions. Future research directions challenges field also proposed.

Language: Английский

Spatiotemporal release of non-nucleotide STING agonist and AKT inhibitor from implantable 3D-printed scaffold for amplified cancer immunotherapy DOI
Haixia Wang, Zheng Liu,

Youqiang Fang

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122645 - 122645

Published: May 28, 2024

Language: Английский

Citations

11
NIR triggered polydopamine coated cerium dioxide nanozyme for ameliorating acute lung injury via enhanced ROS scavenging DOI Creative Commons
Mingjing Yin,

Doudou Lei,

Yalan Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 8, 2024

Abstract Acute lung injury (ALI) is a life threatening disease in critically ill patients, and characterized by excessive reactive oxygen species (ROS) inflammatory factors levels the lung. Multiple evidences suggest that nanozyme with diversified catalytic capabilities plays vital role this fatal injury. At present, we developed novel class of polydopamine (PDA) coated cerium dioxide (CeO 2 ) (Ce@P) acts as potent ROS scavenger for scavenging intracellular suppressing responses against ALI. Herein, aimed to identify Ce@P combining NIR irradiation could further strengthen its capacity. Specifically, triggered exhibited most antioxidant anti-inflammatory behaviors lipopolysaccharide (LPS) induced macrophages through decreasing levels, down-regulating TNF-α, IL-1β IL-6, up-regulating level cytokine (SOD-2), inducing M2 directional polarization (CD206 up-regulation), increasing expression HSP70. Besides, performed intravenous (IV) injection LPS ALI rat model, found it significantly accumulated tissue 6 h after injection. It was also observed + presented superior inflammation, alleviating diffuse alveolar damage, well promoting repair. All all, has strategy using synergistic enhanced treatment ALI, which can serve promising therapeutic clinical derived diseases well.

Language: Английский

Citations

10
Enhanced diabetic foot ulcer treatment with a chitosan-based thermosensitive hydrogel loaded self-assembled multi-functional nanoparticles for antibacterial and angiogenic effects DOI
Zhiwei Wu, Weiwei Wu, Chi Zhang

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 347, P. 122740 - 122740

Published: Sept. 12, 2024

Language: Английский

Citations

8
Trends and Hotspots in Nanomedicine Applications for Pain: A Bibliometric Analysis from 1999 to 2024 DOI Creative Commons
Shuailei Wang, Yumiao He,

Yuguang Huang

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 6147 - 6163

Published: Feb. 7, 2025

Background: Pain, especially chronic pain, is a leading cause of individuals seeking medical attention and presents significant public health challenge due to its widespread prevalence associated healthcare costs. Nanomedicine has shown considerable potential in pain management research. However, there lack comprehensive bibliometric trend analyses that explore the current status, research hotspots, future directions nanomedicine applications pain. Methods: To fill this gap, we analyzed English language publications related from Web Science Core Collection, spanning period January 1, 1999, May 24, 2024. The analysis focused on publication trends, contributions by countries/regions, institutions, journals, categories, prominent authors, key references, keywords. Results: A total 2370 papers were included. China leads number published (785, 33.12%) hosts numerous high-output institutions funding agencies, followed USA. International Journal Pharmaceutics emerged as journal terms volume. clear interdisciplinary platform been established between field "Nanoparticles" "drug delivery" identified high-frequency drug delivery systems for treatment considered main particularly keyword citation bursts indicate biomarker monitoring trend. Conclusions: application advanced rapidly. Increased international collaboration are necessary with expand diagnosis.

Language: Английский

Citations

0
Recent advances and challenges in metal-based antimicrobial materials: a review of strategies to combat antibiotic resistance DOI Creative Commons
Chuanda Zhu,

Zhenli Diao,

Yuanyuan Yang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 9, 2025

Despite the availability of a series classical antibiotic drugs, bacterial infections continue to represent significant and urgent threat global human health. The emergence drug-resistant bacteria slow pace development have rendered current treatment methods inadequate in meeting clinical demands infections. Consequently, there is an increasingly vital need for safe, efficient, alternative novel antimicrobial agents medical healthcare field. Over past five years, has been notable expansion field nanomedicine with regard prevention control infectious diseases. objective this article provide comprehensive review latest research developments metal nanomaterials therapy. We begin by delineating gravity infection crisis, subsequently undertaking examination potential mechanisms through which nanoparticles may combat specific applications these diverse In conclusion, we eagerly anticipate future directions believe that continuous technological advancements innovations, will make even more outstanding contributions safeguarding health well-being.

Language: Английский

Citations

0
An “all-in-one” therapeutic platform for programmed antibiosis, immunoregulation and neuroangiogenesis to accelerate diabetic wound healing DOI
Xue Yang, Lan Zhang, Jun Chen

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123293 - 123293

Published: March 1, 2025

Language: Английский

Citations

0
Bioactive Multifunctional Hydrogels Accelerate Burn Wound Healing via M2 macrophage-polarization, Antioxidant and Anti-inflammatory DOI Creative Commons

Erman Zhao,

Xiuling Tang,

Xitong Li

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101686 - 101686

Published: March 29, 2025

Globally, more than 300,000 fatalities occur from burns annually, and burn-wound healing continues to present significant challenges owing the wound's propensity for infections, heavy bleeding, poor angiogenesis, persistent inflammatory responses. The immunomodulation of macrophage polarization toward M2 phenotype facilitates burn wounds by controlling tissue microenvironment expediting transition phase proliferation. Here, a polydopamine-mediated graphene oxide (GA), tannic acid (TA), magnesium ion (Mg2+)-incorporated multifunctional gelatin (Gel) scaffold (GTMG) is developed accelerate wound modulating wounds. GA Mg2+ confer with conversion M1-type M2-type macrophages vascular regeneration. TA synergistically provide antimicrobial capabilities hydrogel. Additionally, hydrogel shows strong hemostatic, anti-inflammatory biocompatible properties. Due its adhesion injectability, can also be used various forms dynamic In vivo research that may have anti-inflammatory, M2-phenotypic macrophage-polarization effects, which increase regeneration repair effects sites shorten burn-healing time. results indicate this offers promising therapeutic approach treatment altering immunological accelerating three phases healing.

Language: Английский

Citations

0
IR820 Sensitized Ceria Nanozyme via PDA Bridging for Multifaceted Antibacterial Wound Healing Therapy DOI Open Access
Akram Nasser Juaim, Jiao Sun, Ran Nie

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Nanozymes with peroxidase (POD)-like activity hold significant potential for addressing antibiotic-resistant bacterial infections. However, their catalytic efficiency and therapeutic efficacy need further improvement to broaden clinical applications. A key challenge is achieving efficient energy transfer from photosensitizing molecules nanozymes, which critical enhancing performance. In this study, a universal strategy developed bridge nanozymes molecules, designing photoactivated called IR820/PDA@mCeO2 (IR/P@Ce). By integrating IR820, photosensitizer, mesoporous ceria (mCeO2), it facilitates electron through polydopamine (PDA) resulting in enhanced POD-like performance reactive oxygen species production. Additionally, PDA stabilized the nanozyme, improved photothermal therapy, photodynamic therapy under near-infrared light exposure, amplifying destruction. This multifunctional nanozyme demonstrated strong antibacterial against both Gram-positive (Staphylococcus aureus) Gram-negative (Escherichia coli) bacteria. Moreover, its synergistic approach not only facilitated eradication but also accelerated wound healing vivo, making promising alternative managing infections promoting tissue regeneration.

Language: Английский

Citations

0
Injectable glycyrrhizic acid-based hydrogel with Immunoregulatory and angiogenic properties for diabetic wound healing DOI Creative Commons
Haisheng Wu,

Zichao Xue,

Zhigang Wang

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113928 - 113928

Published: April 1, 2025

Language: Английский

Citations

0
Dynamic multistage nanozyme hydrogel reprograms diabetic wound microenvironment: synergistic oxidative stress alleviation and mitochondrial restoration DOI Creative Commons
Jingyu Yan, Yifan Zhao,

Chenying Cui

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101780 - 101780

Published: April 17, 2025

Chronic diabetic wounds remain a significant clinical challenge due to persistent bacterial infections, oxidative stress, impaired angiogenesis, and mitochondrial dysfunction. Traditional therapies often fail address these interrelated pathological factors, highlighting the urgent need for innovative solutions. Here, we present Mn-ZIF@GOx/BC (MZGB) hydrogel system, where Mn-ZIF@GOx (MZG) nanozymes are successfully integrated into cellulose (BC) via hydrogen bonding electrostatic interactions. The MZGB lowers wound pH by oxidizing excess glucose gluconic acid. It exhibits strong ROS scavenging capabilities through its superoxide dismutase catalase-like activities, while simultaneously providing oxygen. By restoring redox homeostasis, it protects function enhances cellular energy metabolism. reprogramming macrophages, creates favorable immune microenvironment, significantly promoting angiogenesis paracrine mechanisms. This facilitates cell-to-cell communication, forming positive feedback loop. Moreover, demonstrates ROS-independent antibacterial properties. BC ensures adhesion moisture regulation, protective barrier maintaining an optimal environment. multifunctional represents promising nanotherapeutic approach efficiently treating precisely regulating microenvironment.

Language: Английский

Citations

0