Polymers for Advanced Technologies,
Journal Year:
2024,
Volume and Issue:
35(12)
Published: Nov. 29, 2024
ABSTRACT
MXene‐based
hydrogels
represent
a
significant
advancement
in
biomedical
material
science,
leveraging
the
unique
properties
of
2D
MXenes
and
versatile
functionality
hydrogels.
This
review
discusses
recent
developments
integration
into
hydrogel
matrices,
focusing
on
their
applications
such
as
wound
healing,
drug
delivery,
antimicrobial
activity,
tissue
engineering,
biosensing.
MXenes,
due
to
remarkable
electrical
conductivity,
mechanical
robustness,
tunable
surface
chemistry,
enhance
properties,
responsiveness
environmental
stimuli.
Specifically,
have
shown
great
promise
accelerating
healing
through
photothermal
effects,
delivering
drugs
controlled
manner,
serving
antibacterial
agents.
Their
also
enables
targeted
cancer
therapies,
including
chemodynamic
facilitated
by
high
conductivity
properties.
Despite
promising
progress,
challenges
ensuring
biocompatibility
optimizing
synthesis
for
large‐scale
production
remain.
aims
provide
comprehensive
overview
current
state
applications,
highlighting
ongoing
advancements
potential
future
directions
these
multifunctional
materials.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(45)
Published: Oct. 11, 2024
Abstract
Oral
ulcers
can
be
addressed
using
various
biomaterials
designed
to
deliver
medications
or
cytokines.
Nevertheless,
the
effectiveness
of
these
substances
is
frequently
limited
in
many
patients
due
poor
adherence,
short
retention
time
mouth,
and
less‐than‐optimal
drug
efficacy.
In
this
study,
a
new
hydrogel
patch
(FSH3)
made
silk
fibroin/hyaluronic
acid
matrix
with
light‐sensitive
adhesive
qualities
infused
ferric
iron/shikonin
nanoparticles
enhance
healing
effects
presented.
Initially,
forms
an
barrier
over
mucosal
lesions
through
straightforward
local
injection,
solidifying
when
exposed
UV
light.
Subsequently,
FSH3
demonstrates
superior
reactive
oxygen
species
elimination
near‐infrared
photothermal
bactericidal
activity.
These
characteristics
support
bacterial
regulate
oxidative
levels,
promoting
wound's
progression
from
inflammation
tissue
regeneration.
diabetic
rat
model
mimicking
oral
ulcers,
significantly
speeds
up
by
adjusting
inflammatory
environment
injured
tissue,
maintaining
balance
microbiota,
faster
re‐epithelialization.
Overall,
shows
potential
for
rapid
wound
recovery
may
transform
therapeutic
methods
managing
diabetes.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 6, 2024
Abstract
Diabetes
significantly
impairs
the
body's
wound‐healing
capabilities,
leading
to
chronic,
infection‐prone
wounds.
These
wounds
are
characterized
by
hyperglycemia,
inflammation,
hypoxia,
variable
pH
levels,
increased
matrix
metalloproteinase
activity,
oxidative
stress,
and
bacterial
colonization.
complex
conditions
complicate
effective
wound
management,
prompting
development
of
advanced
diabetic
care
strategies
that
exploit
specific
characteristics
such
as
acidic
pH,
high
glucose
stress
trigger
controlled
drug
release,
thereby
enhancing
therapeutic
effects
dressings.
Among
solutions,
hydrogels
emerge
promising
due
their
stimuli‐responsive
nature,
making
them
highly
for
managing
these
The
latest
advancements
in
mono/multi‐stimuli‐responsive
smart
showcase
superiority
potential
healthcare
materials,
highlighted
relevant
case
studies.
However,
traditional
dressings
fall
short
meeting
nuanced
needs
wounds,
adjustable
adhesion,
easy
removal,
real‐time
status
monitoring,
dynamic
release
adjustment
according
wound's
conditions.
Responsive
represent
a
significant
leap
forward
proficient
sensing
responding
environment,
offering
more
targeted
approach
treatment.
This
review
highlights
recent
dressing,
delivery,
emphasizing
role
improving
healing.
It
addresses
ongoing
challenges
future
directions,
aiming
guide
clinical
adoption.
Therapeutic Delivery,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 15
Published: Jan. 27, 2025
Natural
hydrogels
have
garnered
increasing
attention
due
to
their
natural
origins
and
beneficial
roles
in
wound
healing.
Hydrogel
water-retaining
capacity
excellent
biocompatibility
create
an
ideal
moist
environment
for
healing,
thereby
enhancing
cell
proliferation
tissue
regeneration.
For
this
reason,
naturally
derived
formulated
from
biomaterials
such
as
chitosan,
alginate,
gelatin,
fibroin
are
highly
promising
biodegradability
low
immunogenic
responses.
Recent
integrated
approaches
utilizing
new
technologies
with
bioactive
agents
significantly
improved
the
mechanical
properties
of
controlled
release
delivery
active
compounds,
efficiency
treatment
processes.
Herein,
review
highlights
advantages
challenges
focusing
on
strength,
degradation
rates,
safety
validation,
potential
incorporating
advanced
engineering
gene
therapy
utilization
personalized
medicine.
Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
6(14), P. 3513 - 3532
Published: Jan. 1, 2024
Recent
advancements
in
MXene-based
wound
dressings
are
discussed,
focusing
on
their
contributions
to
tissue
regeneration,
infection
control,
anti-inflammation
and
photothermal
effects,
targeted
therapeutic
delivery.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(39)
Published: July 15, 2024
Abstract
Growing
demand
for
wound
care
resulting
from
the
increasing
chronic
diseases
and
trauma
brings
intense
pressure
to
global
medical
health
service
system.
Artificial
skin
provides
mechanical
microenvironmental
support
wound,
which
is
crucial
in
healing
tissue
regeneration.
However,
challenges
still
remain
clinical
application
of
artificial
since
lack
synergy
effect
necessary
performance.
In
this
study,
a
multi‐functional
fabricated
through
microfluidic
spinning
technology
by
using
core‐shell
gel
nanofiber
scaffolds
(NFSs).
This
strategy
can
precisely
manipulate
microstructure
under
microscale.
The
as‐prepared
demonstrates
superior
characteristics
including
surface
wettability,
breathability,
high
strength,
strain
sensitivity,
biocompatibility
biodegradability.
Notably,
has
capability
deliver
medications
controlled
sustained
manner,
thereby
accelerating
process.
innovative
approach
paves
way
development
new
generation
introduces
novel
concept
structural
design
unique
NFSs.
