Recent advances in gut microbiota and thyroid disease: pathogenesis and therapeutics in autoimmune, neoplastic, and nodular conditions DOI Creative Commons
Lihua Fang, Jie Ning

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 24, 2024

This review synthesizes key findings from the past five years of experimental literature, elucidating gut microbiome’s significant influence on pathogenesis thyroid diseases. A pronounced shift in microbiota composition has been consistently observed, with a reduction bacteria such as Bifidobacterium , Bacillaceae Megamonas and Clostridium notable increase bacteria, including Bacteroides Proteobacteria Actinobacteria Desulfobacterota Klebsiella . These alterations are implicated development progression diseases by impacting metabolic pathways bile acid cytokine production, decrease short-chain fatty acids (SCFAs) that crucial for immune regulation hormone homeostasis. The also highlights therapeutic implications probiotics managing conditions. Evidence suggests probiotic adjunct therapy can modulate microbiota, leading to improvements function patient outcomes. use specific strains, Lactiplantibacillus plantarum 299v longum demonstrated potential enhancing effects traditional treatments possibly restoring balanced microbiota. Notably, fecal transplantation (FMT) emerged promising intervention Graves’ Disease (GD), demonstrating recalibrate thereby influencing neurotransmitters trace elements via gut-brain gut-thyroid axes. integration microbiome-based therapies is anticipated usher new era personalized disease management, offering more nuanced approach care. By integrating this body work, offers an innovative perspective broad impact applications probiotics.

Language: Английский

Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics DOI Creative Commons
A. Chen, Ying Gong,

S. C. Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 1, 2025

Language: Английский

Citations

3
Probiotic nanocomposite materials with excellent resistance, inflammatory targeting, and multiple efficacies for enhanced treatment of colitis in mice DOI Creative Commons

Yuewen Huang,

He Cai, Huipeng Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 8, 2025

The occurrence of inflammatory bowel disease (IBD) is relevant to impaired intestinal mucosal barrier and disordered gut microbiota, subsequently leading excessive production reactive oxygen species (ROS) elevated levels factors. Traditional therapies focus on inhibiting inflammation, but the vast majority involve non-targeted systemic administration, whose long-term use may result in potential side effects. Oral microbial therapy has exhibited great application prospects currently IBD treatment; however, its progress been slowed by issues with deficient bioavailability, poor targeting colitis, low therapeutic efficacy. Consequently, it exceedingly desirable develop a strategy which probiotics can be endowed additional anti-inflammatory antioxidant properties, as well enhanced inflamed intestine. Herein, we present an innovative for encapsulating probiotic Bacillus coagulans spores rosmarinic acid (RA) silk fibroin (SF). Probiotics spore morphology possessed strong gastrointestinal environmental resistance; RA alleviated oxidative damage scavenging ROS inhibited responses; SF assisted release colonize We demonstrated efficacy composite materials colitis mouse model, significantly series symptoms, cytokine storms, restored balance downregulated inflammation-related signaling pathways. are optimistic that utilization nanocoating modify will open up novel avenues future IBD.

Language: Английский

Citations

1
Bioorthogonal conjugation and responsive nanocoating of probiotics for inflammatory bowel disease DOI
Pandi Peng, Tao Feng, Xue Yang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 374, P. 538 - 549

Published: Aug. 30, 2024

Language: Английский

Citations

6
Analysis of nanomedicine applications for inflammatory bowel disease: structural and temporal dynamics, research hotspots, and emerging trends DOI Creative Commons
Hongyu Jiang, Bo Shao, Hongda Wang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

The application of nanomedicine in inflammatory bowel disease (IBD) has gained significant attention the recent years. As field rapidly evolves, analyzing research trends and identifying hotpots are essential for guiding future advancements, a comprehensive bibliometric can provide valuable insights. current focused on publications from 2001 to 2024, was sourced Web Science Core Collection (WoSCC). CiteSpace VOSviewer were employed visualize authors, institutions, countries, co-cited references, keywords, thereby mapping intellectual structure emerging field. analysis covered 1,518 literature across 447 journals, authored by 9,334 researchers 5,459 institutions 287 countries/regions. global publication numbers exhibited an upward trend, particularly last decade, with China leading as top publishing country Chinese Academy Sciences foremost institution. Dr. Xiao Bo is prominent figure advanced drug delivery systems. This interdisciplinary field, which spans materials science, pharmacy, medicine, seen influential mainly concentrated targeted nanoparticles treatment IBD. Keyword revealed that hotspots include delivery, immune cell regulation, antioxidant damage, intestinal microbiota homeostasis, nanovesicles. study offers overview landscape, emphasizing rapid growth increasing complexity this It identifies key trends, including efforts enhance precision, efficacy, safety applications. Emerging directions highlighted crucial further progress evolving area.

Language: Английский

Citations

0
Preparation of polyvinyl alcohol/Pullulan nanofibers and Eudragit® S100/polyvinyl alcohol/Pullulan core-shell nanofibers for enhanced probiotic storage and oral viability DOI
Yian Wang,

Yingxue Yue,

Shengjun Yang

et al.

Food Hydrocolloids, Journal Year: 2025, Volume and Issue: unknown, P. 111172 - 111172

Published: Feb. 1, 2025

Language: Английский

Citations

0
“Shield” Armed Programmable Probiotics Harboring α-Aminoadipate Aminotransferase Gene Regulate Tryptophan Metabolism and Gut Microbiota to Alleviate the Inflammatory Bowel Disease DOI

A Liu,

Jun Ma,

Zengguang Liu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Current treatment of inflammatory bowel disease (IBD) relies on anti-inflammatory and immunosuppressive agents. However, this concept is considered outdated due to its restricted efficacy unavoidable side effects. Herein, a polynorepinephrine-coated programmable probiotic expressing α-aminoadipate aminotransferase (NE-EcN-pA) was constructed improve the levels kynurenic acid xanthurenic in intestine by modulating endogenous tryptophan metabolism. The NE layer could protect EcN-pA against harsh environment gastrointestinal tract, enhancing survival colonization. In UC mice, oral administration NE-EcN-pA effectively alleviated intestinal inflammation restored epithelial barrier owing activation aryl hydrocarbon receptor pathway. Furthermore, promoted diversity flora, improved imbalance enhanced content short-chain fatty acids colon. Overall, can regulate metabolism gut microbiota, showing promise disorders.

Language: Английский

Citations

0
Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics DOI Creative Commons
Wenxin Chen,

Qiyan Guo,

Hong Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Micro- and nanoplastics, particularly those derived from food-contact materials like polyethylene terephthalate (PET), can damage gut barriers, making the gastrointestinal system more vulnerable to inflammation infections. Here, a probiotic-based drug delivery (EcNT@L) is devised mitigate nanoplastics-induced barrier dysfunction by modulating immunity microbiota. Escherichia coli Nissle 1917 (EcN) genetically engineered produce transforming growth factor-β (TGF-β) then modified with an Eudragit L100-55 coating. This probiotic acts as in vivo "drug factory", exerting anti-inflammatory immune-regulatory effects, improved retention bioavailability tract. EcNT@L effectively protects Caco-2 cells infections induced nano PET, primarily activating NF-κB signaling pathway. Besides, demonstrates superior therapeutic efficacy treating infection caused combined presence of PET Salmonella, outperforming commercial antibiotics due its ability modulate immune responses study highlights potential systems addressing dysfunctions, offering promising strategy for mitigating environmental impact micro- nanoplastics.

Language: Английский

Citations

0
Antioxidant and immunomodulator nanoengineered probiotics for synergistic therapy of inflammatory bowel disease DOI
Pandi Peng, Rui Ding, Junru Wang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162678 - 162678

Published: April 1, 2025

Language: Английский

Citations

0
Oral delivery of probiotic combined natural phenolic-metal framework with microencapsulation for prolonged intestinal retention and alleviation of inflammatory bowel disease DOI

Mengna Zhao,

Longkai Mu,

Fangqin Xiang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162763 - 162763

Published: April 1, 2025

Language: Английский

Citations

0
Overcoming Immunotherapy Resistance in Colorectal Cancer through Nano-Selenium Probiotic Complexes and IL-32 Modulation DOI
Shiquan Li, Tao Liu, Chenyao Li

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 320, P. 123233 - 123233

Published: March 1, 2025

Language: Английский

Citations

0