Electrical Microneedles for Wound Treatment DOI Creative Commons
Yu Wang, Lijun Cai, Fan Lü

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Electrical stimulation has been hotpot research and provoked extensive interest in a broad application such as wound closure, tissue injury repair, nerve engineering. In particular, immense efforts have dedicated to developing electrical microneedles, which demonstrate unique features terms of controllable drug release, real-time monitoring, therapy, thus greatly accelerating the process healing. Here, review state-of-art concerning microneedles applied for treatment is presented. After comprehensive analysis mechanisms on healing, derived three types are clarified summarized. Further, their applications healing highlighted. Finally, current perspectives directions development future improving addressed.

Language: Английский

Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective DOI

Devesh Kumar,

Shubham Pandey,

Jailani Shiekmydeen

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 8, 2025

Language: Английский

Citations

4
Multifunctional hyaluronic acid microneedle patch enhances diabetic wound healing in diabetic infections DOI

Quanyi Lu,

Xiangsheng Tang,

Bailong Tao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 296, P. 139685 - 139685

Published: Jan. 10, 2025

Language: Английский

Citations

2
Tumor‐Associated Macrophages Nano‐Reprogrammers Induce “Gear Effect” to Empower Glioblastoma Immunotherapy DOI Open Access
Yang Wang, Guangzhe Li,

Jianlong Su

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Glioblastoma (GBM), the most malignant brain tumor with high prevalence, remains highly resistant to existing immunotherapies due significant immunosuppression within microenvironment (TME), predominantly manipulated by M2‐phenotypic tumor‐associated macrophages (M2‐TAMs). Here in this work, an M2‐TAMs targeted nano‐reprogrammers, MG5‐S‐IMDQ, is established decorating mannose molecule as targeting moiety well toll‐like receptor (TLR) 7/8 agonist, imidazoquinoline (IMDQ) on dendrimeric nanoscaffold. MG5‐S‐IMDQ demonstrated excellent capacity of penetrating blood‐brain barrier (BBB) selectively GBM microenvironment, leading a phenotype transformation and function restoration TAMs shown heightened phagocytic activity toward cells, enhanced cytotoxic effects, improved antigen cross‐presentation capability. In meantime, induction function‐oriented “gear effect”, treatment extended its impact systemically enhancing infiltration type I conventional dendritic cells (cDC1s) into sites bolstering adaptive immune responses. sum, precisely working unique target situ, nano‐reprogrammers successfully robust network that worked synergistically combat tumors. This facile nanoplatform‐based immunomodulatory strategy, serving powerful convenient monotherapy or complementary alongside other therapies like surgery, provided deep insights for advancing translational study GBM.

Language: Английский

Citations

1
Engineered Enucleated Mesenchymal Stem Cells Regulating Immune Microenvironment and Promoting Wound Healing DOI

Zhengtai Chen,

Yang Zou,

Hanxiao Sun

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Abstract Persistent excessive inflammation caused by neutrophil and macrophage dysfunction in the wound bed leads to refractory response during healing. However, previous studies using cytokines or drugs often suffer from short half‐lives limited targeting, resulting unsatisfactory therapeutic effects. Herein, enucleated mesenchymal stem cell is engineered aptamer bioorthogonal chemistry modify membrane mRNA loading cytoplasm as a novel delivery vector (Cargocyte) with accurate targeting sustained cytokine secretion. Cargocytes can successfully reduce NETosis nuclear chromatin protein DEK aptamers sustaining interleukin (IL)‐4 expression overcome challenges associated high cost half‐life of IL‐4 significantly prevent transition macrophages into M1 phenotype. Therapeutic effects have been demonstrated murine porcine models powerful potential improve immune microenvironments effectively. Overall, use cells system may be promising approach for

Language: Английский

Citations

4
Smart Microneedles in Biomedical Engineering: Harnessing Stimuli‐Responsive Polymers for Novel Applications DOI

Farangis Shahi,

Hana Afshar,

Elmuez A. Dawi

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.

Language: Английский

Citations

4
Biochemical Strategy-Based Hybrid Hydrogel Dressing-Mediated In Situ Synthesis of Selenoproteins for DFU Immunity-Microbiota Homeostasis Regulation DOI
Xueling Liu, Weidi Wang, Yali Wang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123114 - 123114

Published: Jan. 21, 2025

Language: Английский

Citations

0
Smart Bactericidal Textile Enabling In-Situ Visual Assessment of Antimicrobial Activity DOI

Amparo Ferrer Vilanova,

Josune J. Ezenarro, Kristina Ivanova

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
A calcitonin gene-related peptide co-crosslinked hydrogel promotes diabetic wound healing by regulating M2 macrophage polarization and angiogenesis DOI Creative Commons
Xiangyu Li,

Min Yi,

Ziyan Song

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Delayed diabetic wound (DBW) healing is a severe complication of diabetes, characterized notably by peripheral sensory neuropathy. The underlying mechanism nerves and DBW remain unclear. Here, we demonstrate the role calcitonin gene-related peptide (CGRP) in regulating epithelialization angiogenesis DBW. Subsequently, design synthesis gelatin methacryloyl (GelMA-CGRP) hydrogel that slowly releases CGRP, evaluated its effect on promoting healing. results show CGRP abnormally downregulated DBW, ablation further delays This due to reduced M2 polarization decreased absence whereas local application GelMA-CGRP accelerates Mechanistic studies indicate promotes macrophage inhibiting p53 signaling pathway enhances endothelial cell function, thereby accelerating These findings suggest could provide novel therapeutic approach for treatment. STATEMENT OF SIGNIFICANCE: Current methods treating wounds have many limitations. Compared conventional dressings, hydrogels combined with drugs or biological factors promote become an important research direction recent years. study reveals key pathogenesis wounds. found pathway, We utilized carrier properties GelMA develop material delivers effectively treats demonstrates strong biocompatibility antimicrobial properties, offering treatment

Language: Английский

Citations

0
Smart Bactericidal Textile Enabling In-Situ Visual Assessment of Antimicrobial Activity DOI Creative Commons
Amparo Ferrer-Vilanova, Josune J. Ezenarro, Kristina Ivanova

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101724 - 101724

Published: April 6, 2025

Hospital fabrics and wound dressings with antibacterial properties are essential to minimize infection risks associated bacterial colonization of textiles. A key challenge these materials lies in the difficulty assessing their functional lifespan. Integrating bacterial-sensing elements into smart textiles enables real-time in-situ evaluation activity. However, this approach is often hindered by reactivity between bactericidal components, limited stability selectivity sensing probes, high production costs. Here, we address challenges presenting a textile that simultaneously provides activity capacity using layer-by-layer sonochemical deposition method. Prussian blue, chromogenic probe, integrated onto hospital-grade containing copper oxide nanoparticles. When biocidal fabric begins lose its antimicrobial activity, live bacteria metabolically reduce blue nanoparticles, triggering visible colour change. This offers several advantages, such as: (i) resulting retains comparable conventional oxide-based (A value > 4 both cases); (ii) it direct transition from colourless (>20 % losses) when coating effectiveness, enabling straightforward monitoring lifespan without external instruments or reagents; (iii) co-immobilization enhances stability, nearly doubling binding strength compared single-layer coatings; (iv), additional layer significantly reduces material cytotoxicity, enhancing biocompatibility for safer use healthcare settings. These innovations offer scalable, cost-effective, multifunctional solution control. The not only prevents spread but also timely, visual indications degradation, making promising tool improving patient safety hospitals minimizing schools other high-risk environments.

Language: Английский

Citations

0
Boosting hydrogel conductivity via water-dispersible conducting polymers for injectable bioelectronics DOI Creative Commons
Hossein Montazerian, Elham Davoodi, Canran Wang

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 22, 2025

Abstract Bioelectronic devices hold transformative potential for healthcare diagnostics and therapeutics. Yet, traditional electronic implants often require invasive surgeries are mechanically incompatible with biological tissues. Injectable hydrogel bioelectronics offer a minimally alternative that interfaces soft tissue seamlessly. A major challenge is the low conductivity of bioelectronic systems, stemming from poor dispersibility conductive additives in mixtures. We address this issue by engineering doping conditions hydrophilic biomacromolecules, enhancing polymers aqueous systems. This approach achieves 5-fold increase 20-fold boost compared to conventional methods. The resulting molecularly vivo degradable, making them suitable transient applications. These compatible various such as alginate, forming ionically cross-linkable inks 3D-printed wearable electronics toward high-performance physiological monitoring. Furthermore, integrating fillers gelatin-based bioadhesive hydrogels substantially enhances injectable sealants, achieving 250% greater sensitivity pH sensing chronic wound Our findings indicate dopants effectively tailor conducting fillers, their biodegradability expanding applications implantable biomonitoring.

Language: Английский

Citations

0