Nanomaterials in the diagnosis and treatment of gastrointestinal tumors: New clinical choices and treatment strategies DOI Creative Commons
Liping Chen,

Qingqing Li

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101782 - 101782

Published: April 1, 2025

Language: Английский

The role of B2M in cancer immunotherapy resistance: function, resistance mechanism, and reversal strategies DOI Creative Commons
Xiaowen Han,

Jiayi Zhang,

Weidong Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Immunotherapy has emerged as a preeminent force in the domain of cancer therapeutics and achieved remarkable breakthroughs. Nevertheless, high resistance become most substantial impediment restricting its clinical efficacy. Beta-2 microglobulin (B2M), light chain major histocompatibility complex (MHC) class I, plays an indispensable part by presenting tumor antigens to cytotoxic T lymphocytes (CTLs) for exerting anti-tumor effects. Accumulating evidence indicates that B2M mutation/defect is one key mechanisms underlying immunotherapy resistance. Therefore, elucidating role played devising effective strategies battle against are pressing issues. This review will systematically expound upon them, aiming provide insight into potential promising target anticancer immune response.

Language: Английский

Citations

2
Nanomedicines harnessing cGAS-STING pathway: sparking immune revitalization to transform ‘cold’ tumors into ‘hot’ tumors DOI Creative Commons

Xiaohong Ying,

Qiaohui Chen, Yongqi Yang

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Dec. 23, 2024

Language: Английский

Citations

4
Nanodelivery of arsenic trioxide induces macrophage-governed cGAS-STING signaling to remodel immune microenvironment in hepatocellular carcinoma DOI
Yuyao Li, Jia Shi,

Shihan Yu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159943 - 159943

Published: Jan. 1, 2025

Language: Английский

Citations

0
Understanding the relationship between cuproptosis and the development of hepatocellular carcinoma: implications for targeted therapies DOI Creative Commons

Haixia Zhu,

Yamin Zhao,

Yaxuan Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 12, 2025

Hepatocellular carcinoma (HCC) presents a significant global health challenge, particularly in developing countries where its incidence is markedly elevated. Despite advancements treatment modalities, the high malignancy, metastatic potential, and drug resistance associated with HCC contribute to poor clinical outcomes, underscoring necessity for more profound understanding of pathogenesis. This review meticulously examines role copper apoptosis, novel form programmed cell death linked dysregulated metabolism, development progression HCC. By conducting comprehensive recent literature experimental studies, we elucidate molecular mechanisms through which excess induces oxidative stress, pyroptosis, ferroptosis, thereby influencing tumorigenesis progression. offers valuable insights into intricate relationship between metabolism HCC, positioning apoptosis as potential therapeutic target enhance strategies improve patient outcomes.

Language: Английский

Citations

0
Bibliometric analysis of nanoparticle research for diagnostics and therapeutics in hepatocellular carcinoma DOI Creative Commons
Xiaoqing Li, Yue Li,

Jingyan Zhu

et al.

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 30, 2025

The aim of this study was to explore the bibliometric analysis nanomaterials-based therapies for hepatocellular carcinoma as a means assessing current state development and future trends in field. Literature on nanomedicine interactions searched from core database Web Science visualisation analyses were performed using VOSviewer, CiteSpace GraphPad Prism data software. We focused important keywords, countries, authors, affiliations, journals, literature field nanomaterials HCC. search resulted finalization 421 documents. From 2008 2023, research HCC has developed rapidly, number published papers steadily increased, increasing by about 2300%. There are currently 57 countries involved area. Among them, USA had strongest international cooperation network cooperated most closely with China. Gene delivery carbon nanotubes early immunotherapy nanocarriers recent hotspots. It is that selection drug have become driving carcinoma. combination traditional imaging techniques such MRI can improve diagnosis rate Nanomaterials achieve precise targeting cancer cells encapsulating drugs, loading bioactive molecules or modifying specific ligands, thus significantly improving efficacy effectively reducing adverse reactions therapy.

Language: Английский

Citations

0
Photothermal treatment of prostate tumor with micellar indocyanine green and Napabucasin to co-ablate cancer cells and cancer stem cells DOI
Yun Qu, Beibei Guo, Songsong Zhao

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113704 - 113704

Published: April 1, 2025

Language: Английский

Citations

0
Rapid and portable detection of hepatocellular carcinoma marker alpha-fetoprotein using a droplet evaporation-based biosensor DOI

Ying Ping Jia,

Hui Zhao,

Shichu Huang

et al.

Talanta, Journal Year: 2025, Volume and Issue: 294, P. 128189 - 128189

Published: April 18, 2025

Language: Английский

Citations

0
Nanomaterials in the diagnosis and treatment of gastrointestinal tumors: New clinical choices and treatment strategies DOI Creative Commons
Liping Chen,

Qingqing Li

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101782 - 101782

Published: April 1, 2025

Language: Английский

Citations

0