Enhancing wound healing through innovative technologies: microneedle patches and iontophoresis DOI Creative Commons
Yong Jin, Pham Ngoc Chien,

Pham Thi Nga

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 28, 2024

Introduction Wound healing is a complex process involving multiple stages, including inflammation, proliferation, and remodeling. Effective wound management strategies are essential for accelerating improving outcomes. The CELLADEEP patch, incorporating iontophoresis therapy microneedle technology, was evaluated its potential to enhance the process. Methods This study utilized full-thickness skin defect model in Sprague-Dawley rats, researchers compared outcomes between rats treated with Patch those left untreated. Various histological staining techniques were employed examine assess process, such as H&E, MT immunofluorescence staining. Furthermore, anti-inflammatory proliferative capabilities further investigated using biochemical assays. Results Macroscopic microscopic analyses revealed that patch significantly accelerated closure, reduced width, increased epidermal thickness collagen deposition an untreated group. decreased nitric oxide reactive oxygen species levels, well pro-inflammatory cytokines IL-6 TNF-α, indicating effective modulation of inflammatory response. Immunofluorescence showed markers macrophage activity (CD68, F4/80, MCP-1) group, suggesting controlled inflammation Increased levels vimentin, α-SMA, VEGF, I, TGF-β1 observed, enhanced fibroblast activity, angiogenesis, extracellular matrix production. Discussion demonstrated promoting by modulating response, enhancing tissue proliferation offers promising non-invasive treatment option

Language: Английский

Solvent volatilization annealing-prepared Janus film with asymmetric bioadhesion and inherent biological functions to expedite oral ulcer healing DOI

Yanlv Chen,

W. J. Meng, Hailing Yu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123131 - 123131

Published: Jan. 28, 2025

Language: Английский

Citations

2
Biophysical insights into the impact of lateral electric field stimulation to cellular microenvironment: Implications for Bioelectronic medicine applications DOI
Bikramjit Basu,

D.S. Aditya,

V. Kumaran

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123132 - 123132

Published: Jan. 31, 2025

Language: Английский

Citations

0
Bioinspired Intelligent Electronic Skin for Medicine and Healthcare DOI Open Access
Zhirong Liu,

Junhao Hu,

Guozhen Shen

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Intelligent electronic skin aims to mimic, enhance, and even surpass the functions of biological skin, enabling artificial systems sense environmental stimuli interact more naturally with humans. In healthcare, intelligent is revolutionizing diagnostics personalized medicine by detecting early signs diseases programming exogenous for timely intervention on‐demand treatment. This review discusses latest progress in bioinspired its application healthcare. First, strategies development simulate or human are discussed, focusing on basic characteristics, as well sensing regulating functions. Then, applications health monitoring wearable therapies illustrating potential provide warning Finally, significance bridging gap between emphasized challenges future perspectives summarized.

Language: Английский

Citations

0
Trends in Flexible Sensing Technology in Smart Wearable Mechanisms–Materials–Applications DOI Creative Commons
Sen Wang, Haorui Zhai, Qiang Zhang

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(4), P. 298 - 298

Published: Feb. 15, 2025

Flexible sensors are revolutionizing our lives as a key component of intelligent wearables. Their pliability, stretchability, and diverse designs enable foldable portable devices while enhancing comfort convenience. Advances in materials science have provided numerous options for creating flexible sensors. The core their application areas like electronic skin, health medical monitoring, motion human-computer interaction is selecting that optimize sensor performance weight, elasticity, comfort, flexibility. This article focuses on sensors, analyzing "sensing mechanisms-materials-applications" framework. It explores development trajectory, material characteristics, contributions various domains such interaction. concludes by summarizing current research achievements discussing future challenges opportunities. expected to continue expanding into new fields, driving the evolution smart wearables contributing society.

Language: Английский

Citations

0
Dual network conductive hydrogel for robust epidermal electrode patches DOI
Ke Wu,

Andeng Liu,

Yangyang Chen

et al.

Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 112096 - 112096

Published: March 1, 2025

Language: Английский

Citations

0
Wearable ECG signal sensing system based on easily peelable highly conductive hydrogel DOI
Xueli Nan,

Shixuan Mei,

Lingxiao Xu

et al.

Sensors and Actuators A Physical, Journal Year: 2025, Volume and Issue: unknown, P. 116453 - 116453

Published: March 1, 2025

Language: Английский

Citations

0
Recent advances in cutaneous drug delivery by iontophoresis DOI
Idejan P. Gross, Ana Luiza Lima, Lívia Cristina Lira de Sá Barreto

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Iontophoresis has been extensively studied for topical and transdermal drug delivery to stimulate the absorption of molecules that would hardly pass through outermost layer skin passively. Recent research focused on its combination with nanoparticle-based systems or microneedles expand therapeutic applications. This review explores fundamental principles iontophoresis, focusing key factors influencing transport mechanisms, provides a discussion field's current state. A comprehensive analysis articles published available online in 2024 was conducted, categorizing studies by their application areas, systems, iontophoretic conditions, experimental limitations. The findings reveal recent focus wound healing repair, advancements treating inflammation, pain, cancer. Market translation requires standardized protocols, particularly parameters preclinical models, along development cost-effective commercial devices. Additionally, while cutaneous have increasingly benefited from machine learning approaches, iontophoresis remains underexplored. With growing interest associating Internet Things, such an integration, if combined AI tools, could offer promising opportunities personalized, real-time treatments modern dermatology, systems.

Language: Английский

Citations

0
Design Strategies of PEDOT:PSS-Based Conductive Hydrogels and Their Applications in Health Monitoring DOI Open Access
Yingchun Li,

X Y Zhang,

Shaozhe Tan

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(9), P. 1192 - 1192

Published: April 27, 2025

Conductive hydrogels, particularly those incorporating poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), have revolutionized wearable health monitoring by merging tissue-like softness with robust electronic functionality. This review systematically explores design strategies for PEDOT:PSS-based focusing on advanced gelation methods, including polymer crosslinking, ionic interactions, and light-induced polymerization, to engineer hierarchical networks that balance conductivity mechanical adaptability. Cutting-edge fabrication techniques such as electrochemical patterning, additive manufacturing, laser-assisted processing further enable precise microstructural control, enhancing interfacial compatibility biological systems. The applications of these hydrogels in sensors are highlighted through their capabilities real-time deformation tracking, dynamic tissue microenvironment analysis, high-resolution electrophysiological signal acquisition. Environmental stability long-term durability critical ensuring reliable operation under physiological conditions mitigating performance degradation caused fatigue, oxidation, or biofouling. By addressing challenges environmental durability, PEDOT:PSS demonstrate transformative potential personalized healthcare, where unique combination softness, biocompatibility, tunable electro-mechanical properties enables seamless integration human tissues continuous, patient-specific monitoring. These systems offer scalable solutions multi-modal diagnostics, empowering tailored therapeutic interventions chronic disease management. concludes insights into future directions, emphasizing the intelligent responsiveness energy autonomy advance next-generation bioelectronic interfaces.

Language: Английский

Citations

0
Bioinspired Shape Reconfigurable, Printable, and Conductive “E‐Skin” Patch with Robust Antibacterial Properties for Human Health Sensing DOI Creative Commons

Hojin Kim,

Sayan Deb Dutta, M. Jeon

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract Conductive hydrogel‐based flexible electronic skin, or “E‐skin,” patches have garnered significant attention in biomedical engineering due to their capability sense and detect real‐time human motion, health metrics, environmental changes. Nonetheless, challenges such as precision fabrication, enhanced flexibility, superior self‐healing, hydrophilicity, insufficient bioadhesive properties impede clinical application limit advancement wearable bioelectronics. In this context, the development of a highly flexible, shape‐reconfigurable, stretchable, printable conductive “E‐skin” patch for humidity, temperature sensing. This utilizes polyvinyl alcohol/gelatin/carbon nanotubes/cellulose nanocrystals (PVA/Gelatin/CNTs/CNCs PVG/NC) based hydrogel inspired by slime molds. Modifying PVG with CNTs CNCs enhances mechanical viscoelastic properties, thereby facilitating high‐resolution direct ink writing (DIW) 3D printing. The resulting slime‐like demonstrates an electrical conductivity ≈5 ± 0.25 S m −1 , exceptional stretchability (≈1000%). nanocomposite also displays outstanding multiple sensing capabilities temperature, humidity under ambient conditions. Furthermore, PVG/NC showcases remarkable near‐infrared (NIR) responsive attributes, which can be leveraged eradicating pathogenic bacteria chronic wounds exhibit excellent cytocompatibility. research holds immense promise future bioelectronics, particularly non‐invasive medical diagnostics.

Language: Английский

Citations

0
Enhancing wound healing through innovative technologies: microneedle patches and iontophoresis DOI Creative Commons
Yong Jin, Pham Ngoc Chien,

Pham Thi Nga

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 28, 2024

Introduction Wound healing is a complex process involving multiple stages, including inflammation, proliferation, and remodeling. Effective wound management strategies are essential for accelerating improving outcomes. The CELLADEEP patch, incorporating iontophoresis therapy microneedle technology, was evaluated its potential to enhance the process. Methods This study utilized full-thickness skin defect model in Sprague-Dawley rats, researchers compared outcomes between rats treated with Patch those left untreated. Various histological staining techniques were employed examine assess process, such as H&E, MT immunofluorescence staining. Furthermore, anti-inflammatory proliferative capabilities further investigated using biochemical assays. Results Macroscopic microscopic analyses revealed that patch significantly accelerated closure, reduced width, increased epidermal thickness collagen deposition an untreated group. decreased nitric oxide reactive oxygen species levels, well pro-inflammatory cytokines IL-6 TNF-α, indicating effective modulation of inflammatory response. Immunofluorescence showed markers macrophage activity (CD68, F4/80, MCP-1) group, suggesting controlled inflammation Increased levels vimentin, α-SMA, VEGF, I, TGF-β1 observed, enhanced fibroblast activity, angiogenesis, extracellular matrix production. Discussion demonstrated promoting by modulating response, enhancing tissue proliferation offers promising non-invasive treatment option

Language: Английский

Citations

1