Ring opening ring closure reactions with 5,9-diethyl-7-(chromon-3-yl)-7-hydroquinolino[3′,4′:5,6]pyrano[3,2-c]quinoline-6,8(5H,9H)-dione with some 1,2-binucleophiles: Synthesis, characterization, DFT study and biological activity

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1298, P. 137030 - 137030

Published: Nov. 8, 2023

Language: Английский

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Antibacterial Activity and Possibly Made of Action of Isoquinoline-3-Carboxylic Acid

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(2)

Published: Feb. 1, 2024

Objectives Due to the urgent need develop innovative, environmentally sustainable bactericides, we use natural product isoquinoline as a lead compound discover highly active bactericides from derivatives. Methods In this paper, antibacterial activity of 49 derivatives was evaluated against three plant bacteria in vitro. Results Among all derivatives, isoquinoline-3-carboxylic acid (IQ3CA) demonstrated significant Ralstonia solanacearum ( Rs), Acidovorax citrulli Ac), X. oryzae pv. oryzicola Xoc), campestris Xcc), P. carotovorum subsp. Pcc), and fragariae Xf), with EC 50 values ranging 8.38 17.35 μg/mL. Furthermore, IQ3CA exhibited potent protective effect Ac, an efficacy 68.56% at 200 μg/mL, which not significantly different that positive control kasugamycin (72.48%) superior thiosen copper (64.62%). The scanning electron microscopy observations revealed treatment Ac cells concentration 25 μg/mL resulted curved sunken cell morphology, along destroyed membrane integrity. Additionally, motility exopolysaccharides production were inhibited, biofilm formation prevented. Conclusion These results suggest holds promise properties diseases.

Language: Английский

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Visible-Light-Promoted Selenylation/Cyclization of o-Alkynyl Benzylazides/o-Propargyl Arylazides: Synthesis of Seleno-Substituted Isoquinolines and Quinolines

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(6), P. 4176 - 4184

Published: March 4, 2024

A simple and efficient visible-light-promoted selenylation/cyclization of o-alkynyl benzylazides/o-propargyl arylazides have been realized for the practical synthesis seleno-substituted isoquinolines quinolines. This strategy provides valuable isoquinoline quinoline derivatives via construction one C(sp2)–Se bond C–N within process.

Language: Английский

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A facile, environmentally-benign, green and a novel synthesis of tert-butyl-quinolines by using Fe3O4-MWCNT@CeO2 as recyclable catalyst

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 162, P. 112280 - 112280

Published: March 9, 2024

Language: Английский

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EXPANSION STRATEGIES TO DESIGN HYBRID MOLECULES OF FDA APPROVED DRUGS AS POTENTIAL INHIBITORS OF SARS Co-V-2 MAIN PROTEASE (Mpr)

International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 153 - 164

Published: March 7, 2025

Objective: This research was conducted to design hybrid molecules of FDA-approved drugs as potential inhibitors SARS Co-V-2 (Mpr) using computational approach. Methods: work focused on the significance or Mutual Pro-drugs. We have designed a set 20 and applied Molecular Docking, Absorption, Distribution, Metabolism, Excretion, Toxicity (ADMET) tests filter them. The most effective molecule then studied for its stability Dynamic (MD) simulations. Results: found that PH-6a has very low binding energy of-7.58kcal/mol it forms five hydrogen bonds (Met49, Phe140, His163, Glu166) pi bond (Cys145) with crucial residues targeted Mpr protein. It possesses lower toxicity, is impermeable blood-brain barrier (BBB), favourable synthetic availability drug scores. Root mean Square Deviation (RMSD) lead compound (PH-6a) within acceptable range 3 Å total determined be-5.06 kcal/mol, indicating higher level in structure. Conclusion: Our findings offer valuable insights into their application development strategies addressing various emergency viral infections. Additionally, our results contribute creation library compounds therapeutic properties.

Language: Английский

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A Diversity‐Oriented Multicomponent Approach to Novel Fused Nitrogen Heterocycles Using 6‐Aminoindazole

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(14)

Published: April 1, 2025

Abstract We present a novel, efficient, eco‐friendly sonochemical strategy for the synthesis of fused nitrogen heterocycles via Brønsted acid‐promoted, one‐pot multicomponent reactions (MCRs). This method involves rapid assembly 6‐aminoindazole, aryl aldehydes, and 1,3‐cyclodione derivatives (barbituric acid, dimedone, 1,3‐dimethyl barbituric acid) under mild identical reaction conditions. The approach delivers diverse range highly functionalized heterocyclic frameworks, including 11‐phenyl‐1,6,7,11‐tetrahydro‐8 H ‐pyrazolo[3,4‐ f ]pyrimido[4,5‐ b ]quinoline‐8,10(9 )‐dione, 8,8‐dimethyl‐11‐phenyl‐1,6,7,8,9,11‐hexahydro‐10 ]acridin‐10‐one, 7,9‐diphenyl‐1,6,7,9‐tetrahydro‐2′ ‐spiro[pyrazolo[3,4‐ ]quinoline‐8,5′‐pyrimidine]‐2′,4′,6′(1′ ,3′ )‐trione derivatives. molecular structures these compounds were unambiguously confirmed through 1H‐NMR, 13C‐NMR single‐crystal X‐ray diffraction (SC‐XRD) analysis. Additionally, control experiments provided valuable mechanistic insights into pathway. protocol stands out its efficiency, high yields, broad functional group tolerance, making it versatile tool diversity‐oriented in modern chemistry.

Language: Английский

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In vitro and in vivo bioimaging by Quinoline conjugated probes and dyes

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 536, P. 216654 - 216654

Published: April 10, 2025

Language: Английский

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Discovery of new quinoline derivatives bearing 1-aryl-1,2,3-triazole motif as influenza H1N1 virus neuraminidase inhibitors

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 151, P. 107703 - 107703

Published: Aug. 6, 2024

Language: Английский

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Design, synthesis, and antiproliferative screening of new quinoline derivatives bearing a cis-vinyl triamide motif as apoptosis activators and EGFR-TK inhibitors

RSC Advances, Journal Year: 2024, Volume and Issue: 14(34), P. 24781 - 24790

Published: Jan. 1, 2024

A set of novel quinoline tethered cis -vinyl triamides derivatives has been designed, synthesized and screened for in vitro cytotoxicity against the MCF-7 breast adenocarcinoma cell line.

Language: Английский

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Identification of effective anti-HCV and anti-HIV royal jelly constituents and their acute toxicity evaluation in Albino rats

Food and Chemical Toxicology, Journal Year: 2023, Volume and Issue: 182, P. 114170 - 114170

Published: Nov. 8, 2023

Language: Английский

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