The Emerging Role of Ubiquitin-Specific Protease 36 (USP36) in Cancer and Beyond
Meng-Yao Niu,
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Y. Liu,
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Jinjin Shi
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et al.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(5), P. 572 - 572
Published: May 12, 2024
The
balance
between
ubiquitination
and
deubiquitination
is
instrumental
in
the
regulation
of
protein
stability
maintenance
cellular
homeostasis.
deubiquitinating
enzyme,
ubiquitin-specific
protease
36
(USP36),
a
member
USP
family,
plays
crucial
role
this
dynamic
equilibrium
by
hydrolyzing
removing
ubiquitin
chains
from
target
proteins
facilitating
their
proteasome-dependent
degradation.
multifaceted
functions
USP36
have
been
implicated
various
disease
processes,
including
cancer,
infections,
inflammation,
via
modulation
numerous
events,
gene
transcription
regulation,
cell
cycle
immune
responses,
signal
transduction,
tumor
growth,
inflammatory
processes.
objective
review
to
provide
comprehensive
summary
current
state
research
on
roles
different
pathological
conditions.
By
synthesizing
findings
previous
studies,
we
aimed
increase
our
understanding
mechanisms
underlying
these
diseases
identify
potential
therapeutic
targets
for
treatment.
Language: Английский
Unraveling the Role of Ubiquitin-Conjugating Enzyme UBE2T in Tumorigenesis: A Comprehensive Review
Chang Gao,
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Yanjun Liu,
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Jing Yu
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et al.
Cells,
Journal Year:
2024,
Volume and Issue:
14(1), P. 15 - 15
Published: Dec. 26, 2024
Ubiquitin-conjugating
enzyme
E2
T
(UBE2T)
is
a
crucial
in
the
ubiquitin-proteasome
system
(UPS),
playing
significant
role
ubiquitination
of
proteins
and
influencing
wide
range
cellular
processes,
including
proliferation,
differentiation,
apoptosis,
invasion,
metabolism.
Its
overexpression
has
been
implicated
various
malignancies,
such
as
lung
adenocarcinoma,
gastric
cancer,
pancreatic
liver
ovarian
where
it
correlates
strongly
with
disease
progression.
UBE2T
facilitates
tumorigenesis
malignant
behaviors
by
mediating
essential
functions
DNA
repair,
cell
cycle
regulation,
activation
oncogenic
signaling
pathways.
High
levels
expression
are
associated
poor
survival
outcomes,
highlighting
its
potential
molecular
biomarker
for
cancer
prognosis.
Increasing
evidence
suggests
that
acts
an
oncogene
could
serve
promising
therapeutic
target
treatment.
This
review
aims
to
provide
detailed
overview
UBE2T’s
structure,
functions,
mechanisms
involved
progression
well
recent
developments
UBE2T-targeted
inhibitors.
Such
insights
may
pave
way
novel
strategies
diagnosis
treatment,
enhancing
our
understanding
biology
supporting
development
innovative
approaches.
Language: Английский
Research advances on signaling pathways regulating the polarization of tumor-associated macrophages in lung cancer microenvironment
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 31, 2024
Lung
cancer
(LC)
is
one
of
the
most
common
worldwide.
Tumor-associated
macrophages
(TAMs)
are
important
component
tumor
microenvironment
(TME)
and
closely
related
to
stages
occurrence,
development,
metastasis.
Macrophages
plastic
can
differentiate
into
different
phenotypes
functions
under
influence
signaling
pathways
in
TME.
The
classically
activated
(M1-like)
alternatively
(M2-like)
represent
two
polarization
states
macrophages.
M1
exhibit
anti-tumor
functions,
while
M2
considered
support
cell
survival
Macrophage
involves
complex
pathways,
blocking
or
regulating
these
enhance
macrophages'
effects
has
become
a
research
hotspot
recent
years.
At
same
time,
there
have
been
new
discoveries
regarding
modulation
TAMs
towards
an
phenotype
by
synthetic
natural
drug
components.
Nanotechnology
better
achieve
combination
therapy
targeted
delivery
drugs,
maximizing
efficacy
drugs
minimizing
side
effects.
Up
now,
nanomedicines
targeting
various
active
substances
for
reprogramming
made
significant
progress.
In
this
review,
we
primarily
provided
comprehensive
overview
crosstalk
between
cells
LC
microenvironment.
Additionally,
latest
advancements
novel
nano-based
systems
(NDDSs)
that
target
were
also
reviewed.
Finally,
discussed
prospects
as
therapeutic
targets
barriers
clinical
translation.
Language: Английский
Identification of potential inhibitors of Ubiquitin carboxyl-terminal hydrolase 21 from repurposed drugs: Implications in anticancer therapeutics
Chemical Physics Impact,
Journal Year:
2024,
Volume and Issue:
unknown, P. 100792 - 100792
Published: Nov. 1, 2024
Language: Английский