Russian Journal of General Chemistry, Journal Year: 2024, Volume and Issue: 94(12), P. 3217 - 3222
Published: Dec. 1, 2024
Language: Английский
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: 1872(3), P. 119910 - 119910
Published: Jan. 29, 2025
Language: Английский
Citations
0
Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 22, 2025
Abstract Two new series of pyrimidinyl ethyl pyrazoles derivatives 13a–f and 14a–f were designed synthesized to possess both anticancer effect by inhibiting BRAFV600E anti-inflammatory JNK isoforms. The structure the compounds was generated from hybridization two main moieties. moiety reported inhibitors, pyrazole isoforms inhibitors. final tested on BRAFV600E, JNK1, JNK2, JNK3 measure their kinases inhibitory effect. Compound 14c showed highest activity with IC 50 = 0.51 μM, 0.53 1.02 0.009 μM JNK3,and respectively. All over four cancer cell lines related target enzymes. 14d most potent all 0.87 0.91, 0.42 0.63 MOLT-4, K-562, SK-MEL-28, A375 lines, ability inhibit MEK1/2 ERK1/2 phosphorylation performed using western blot. cycle analysis compound line revealed that arrested growth at G0-G1 phase. remarkably decreased migration compared control group in traditional test. Compounds significant nitric oxide release PGE2 production raw 264.7 macrophages. 13d 1 4d exhibited high iNOS COX-2 COX-1. Finally, TNF-alpha IL-6 determined. Graphical abstract synthesized. able BRAFV600E. play a key role inflammatory disorders. Final for activities.
Language: Английский
Citations
0
Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(2), P. 10 - 10
Published: April 9, 2025
Nanotheranostics—where nanoscale materials serve both diagnostic and therapeutic functions—are rapidly transforming gene therapy by tackling critical delivery challenges. This review explores the design engineering of various nanoparticle systems (lipid-based, polymeric, inorganic, hybrid) to enhance stability, targeting, endosomal escape genetic payloads. We discuss how real-time imaging capabilities integrated into these platforms enable precise localization controlled release genes, improving treatment efficacy while reducing off-target effects. Key strategies overcome barriers (such as proton sponge effect photothermal disruption) achieve nuclear are highlighted, along with recent advances in stimuli-responsive that facilitate spatiotemporal control expression. Clinical trials preclinical studies demonstrate expanding role nanotheranostics managing cancer, inherited disorders, cardiovascular neurological diseases. further address regulatory manufacturing hurdles must be for widespread clinical adoption nanoparticle-based therapies. By synthesizing progress ongoing challenges, this underscores transformative potential effective, targeted, image-guided delivery.
Language: Английский
Citations
0
Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 10, 2024
Abstract Developing new molecular entities is one of the most emerging research areas in field Medicinal Chemistry. Over past few years, rigorous has been conducted on sulfaguanidine‐linked synthetic molecules because their promising potential several biological activities. Sulfaguanidine actively incorporated design anticancer, antimicrobial, antidiabetic, antiparkinsonian, anti‐inflammatory, and antiviral candidates. The construction these effective candidates adopted many chemical approaches. A number prepared compounds displayed results that merit further investigations for development medications. This review summarizes different strategies reported activities throughout 2020–2024.
Language: Английский
Citations
1
Russian Journal of General Chemistry, Journal Year: 2024, Volume and Issue: 94(12), P. 3217 - 3222
Published: Dec. 1, 2024
Language: Английский
Citations
0