Novel hybrid structures based on 4-Chlorobenzenesulfonyl and 1,2,3-triazoles: Synthesis, in vitro biological activities and in silico studies

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 409, P. 125501 - 125501

Published: July 14, 2024

Language: Английский

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Insights into antimicrobial potential of functionalized thiazoles: In vitro and in silico analysis

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127064 - 127064

Published: Feb. 1, 2025

Language: Английский

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New antiproliferative 1,3,4-oxadiazole/benzimidazole derivatives: Design, synthesis, and biological evaluation as dual EGFR and BRAFV600E inhibitors

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 157, P. 108297 - 108297

Published: Feb. 21, 2025

Language: Английский

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Advances in the structures, mechanisms and targeting of molecular chaperones

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 12, 2025

Abstract Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention protein misfolding and abnormal aggregation, modulation homeostasis, protection cells from damage under constantly changing environmental conditions. As understanding biological mechanisms molecular chaperones has increased, their link with occurrence progression disease suggested that these proteins are promising targets for therapeutic intervention, drawing intensive interest. Here, we review recent advances determining structures heat shock 90 (HSP90) chaperone system complexes. We also describe features shed light on complicated mechanism operates through interactions various co-chaperones cycles. In addition, how affect diseases by regulating pathogenic been thoroughly analyzed. Furthermore, focus to systematically discuss clinical drug design strategies preclinical stage. Recent studies have identified variety novel targeting systems compounds act different those traditional inhibitors. Therefore, as more developed, will significantly contribute discovery new potential drugs.

Language: Английский

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Synthesis of Novel Cyano-Acetic Acid Hydrazide Derivatives as precursor for Generation of Dihydropyridine and Pyrrole as Anticancer Agents: Multi-Target Recognition, In Vitro and In Silico Studies

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141501 - 141501

Published: Jan. 1, 2025

Language: Английский

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Recent progress and structural insights of potential Hsp90 inhibitors as anticancer agents

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

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Thiazolopyrimidine, a privileged scaffold: Recent updates on synthetic and pharmacological perspective in drug discovery

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)

Published: March 1, 2025

Abstract Heterocyclic compounds are emerging as a privileged scaffold with plethora of biological activities. In recent years, interest in thiazolopyrimidine chemistry has significantly increased due to its diverse pharmacological activities, such anticancer, antimicrobial, analgesic, antioxidant, anti‐inflammatory, and so on. It provides various opportunities for structural modifications. The key intermediate the synthesis fused heterocycles medicinal importance. By considering role this scaffold, researchers have designed different synthetic protocols derivatives. present review, several advancements methodology derivatives substitutions been discussed along activity, which insights into protocol on core moiety rational drug design discovery.

Language: Английский

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Revealing the Anti-Cancer Potential of 1,2,3-Triazole-Isonicotinate Derivatives Targeting EGFR Kinase Inhibition in MCF-7 Cancer Cells: Design, Synthesis, Biological Evaluation, and In Silico Studies

Polycyclic aromatic compounds, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: April 28, 2025

Language: Английский

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Investigating the Efficacy of Naphthalene-Thiazole Hybrid hydrazones as α-Glucosidase Inhibitors

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140288 - 140288

Published: Oct. 6, 2024

Language: Английский

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Design, synthesis and biological studies of new isoxazole compounds as potent Hsp90 inhibitors

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 14, 2024

Heat shock protein 90 (Hsp90), a molecular chaperone, contributes to the preservation of folding, structure, stability, and function proteins. In this study, novel compounds comprising isoxazole structure were designed, synthesized their potential ability as Hsp90 inhibitors was validated through docking studies. The active site-based prepared multi-step synthesis process chemical structures characterized employing FT-IR, NMR, mass spectrometry analysis. Cytotoxic inhibition activities assessed by MTT assay ELISA kit, respectively. Based on obtained results, compound 5 exhibited highest cytotoxicity (IC50; 14 µM) against cancer cells reduced expression from 5.54 ng/mL in untreated (normal cells) 1.56 cells. Moreover, dynamics (MD) simulation results indicated its high affinity target approved excellent stability which is essential for exerting an inhibitory effect cell proliferation.

Language: Английский

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