Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 6413 - 6426

Published: Dec. 1, 2024

In recent years, the incidence of fungal infections has been rising annually, especially among immunocompromised populations, posing a significant challenge to public health. Although antifungal medications provide some relief, escalating problem resistance sharply curtails their effectiveness, presenting an urgent clinical dilemma that demands immediate attention. Research shown is closely related quorum sensing (QS), and QS inhibitors (QSIs) are considered effective solution this issue. Garlic, as natural QSI, demonstrated effects in inhibiting growth, preventing biofilm formation, enhancing immunity, combating resistance. This study explores potential garlic mitigating drug identifies its key role mechanism, these findings offer new perspective for treatment infections, addressing increasingly severe However, application still faces several challenges, such ensuring standardization active ingredient extraction, well issues safety stability. Future research should focus on mechanism promote interdisciplinary collaboration develop more natural, effective, safe QSI drugs like garlic, while actively conducting trials validate efficacy safety. Additionally, incorporating advanced technologies nanotechnology enhance stability targeting, comprehensive strategy infections. Overall, Our provides scientific evidence supporting novel lays groundwork development future QSIs therapeutic use. It offers insights, particularly populations drug-resistant strains.

Language: Английский