Mitophagy in Human Diseases

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(8), P. 3903 - 3903

Published: April 9, 2021

Mitophagy is a selective autophagic process, essential for cellular homeostasis, that eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays an important role during development and fundamental in highly differentiated post-mitotic cells are dependent on aerobic metabolism, such as neurons, muscle cells, hepatocytes. Both defective excessive mitophagy have been proposed to contribute age-related neurodegenerative diseases, Parkinson’s Alzheimer’s metabolic vascular complications of diabetes, myocardial injury, dystrophy, liver disease, among others. Pharmacological or dietary interventions restore homeostasis facilitate the elimination irreversibly damaged mitochondria, thus, could serve potential therapies several chronic diseases. However, despite extraordinary advances this field, mainly derived from vitro preclinical animal models, human applications based regulation mitochondrial quality patients not yet approved. In review, we summarize key autophagy pathways their prevalent diseases highlight use specific interventions.

Language: Английский

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Therapeutic Applications of Terpenes on Inflammatory Diseases

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 13, 2021

In the last decades, search for natural products with biological applications as alternative treatments several inflammatory diseases has increased. this respect, terpenes are a family of organic compounds obtained mainly from plants and trees, such tea, cannabis, thyme, citrus fruits like lemon or mandarin. These molecules present attractive properties analgesic anticonvulsant activities. Furthermore, studies have demonstrated that certain could reduce inflammation symptoms by decreasing release pro-inflammatory cytokines example, nuclear transcription factor-kappa B, interleukin 1, tumor necrosis factor-alpha. Thus, due to various anti-inflammatory drugs provoking side effects, analysis novel therapeutics attractive. review, terpenes’ chemical structure their mechanisms in functions addressed. Additionally, we general recent investigations about an treatment diseases. focus on terpenes-based nanoformulations employed dosages offer global perspective state-of-the-art.

Language: Английский

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Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age

Biomolecules, Journal Year: 2022, Volume and Issue: 12(3), P. 371 - 371

Published: Feb. 25, 2022

Alzheimer’s and Parkinson’s diseases are the two most common forms of neurodegenerative diseases. The exact etiology these disorders is not well known; however, environmental, molecular, genetic influences play a major role in pathogenesis Using disease (AD) as archetype, pathological findings include aggregation Amyloid Beta (Aβ) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), cerebrovascular dysregulation. This review highlights neuroinflammatory neuroprotective epigallocatechin-3-gallate (EGCG): medicinal component green tea, known nutraceutical that has shown promise modulating AD progression due to its antioxidant, anti-inflammatory, anti-aging abilities. report also re-examines current literature provides innovative approaches for EGCG be used preventive measure alleviate other disorders.

Language: Английский

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Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 229 - 229

Published: Jan. 10, 2023

Curcumin (CUR) is a polyphenol extracted from the rhizome of Curcuma longa that possesses potent anti-inflammatory and antioxidant potential. Despite CUR’s numerous beneficial effects on human health, it has limitations, such as poor absorption. Nano-based drug delivery systems have recently been applied to improve solubility bioavailability potentialize its health effects. This review investigated different CUR-based nanomedicines inflammatory immunomodulated diseases. PUBMED, EMBASE, COCHRANE, GOOGLE SCHOLAR databases were searched, Scale for Assessment Narrative Review Articles (SANRA) was used quality assessment PRISMA guidelines. Overall, 66 studies included comprising atherosclerosis, rheumatoid arthritis (RA), Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), Huntington’s (HD), bowel diseases (IBD), psoriasis, liver fibrosis, epilepsy, COVID-19. The available scientific show there are many known nanoformulations with curcumin. They can be found in nanosuspensions, nanoparticles, nanoemulsions, solid lipid particles, nanocapsules, nanospheres, liposomes. These formulations CUR effectively adjuvants several immune-mediated atheroma plaque formation, RA, dementia, AD, PD, MS, IBD, COVID-19, anti-fibrotic fibrotic disease.

Language: Английский

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Anticancer effect of terpenes: focus on malignant melanoma

Pharmacological Reports, Journal Year: 2023, Volume and Issue: 75(5), P. 1115 - 1125

Published: July 29, 2023

Melanoma is a highly aggressive and life-threatening form of skin cancer that accounts for significant proportion cancer-related deaths worldwide. Although conventional therapies, such as surgical excision, chemotherapy, radiation, have been used to treat malignant melanoma, their efficacy often limited due the development resistance adverse side effects. Therefore, there growing interest in developing alternative treatment options melanoma are more effective less toxic. Terpenes, diverse group naturally occurring compounds plant origin, emerged potential anticancer agents ability inhibit tumor growth induce apoptosis cells. In this review, current understanding effects terpenes (including, thymoquinone, β-elemene, carvacrol, limonene, α-pinene, β-caryophyllene, perillyl alcohol, taxol, betulinic acid, α-bisabolol, ursolic linalool, lupeol, artesunate) was summarized, with special focus on therapeutic melanoma.

Language: Английский

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Crosstalk between metabolism and cell death in tumorigenesis

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 4, 2024

Abstract It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid proliferation rate, cancer constantly encounter the limits of insufficient oxygen and nutrient supplies. To satisfy their growth needs resist adverse environmental events, modify metabolic pathways produce both extra energies substances required for growth. Realizing characters special will be helpful eliminating them during therapy. Cell death a hot topic long-term study targeting cell one most effective ways repress Many studies have successfully demonstrated metabolism inextricably linked Here we summarize recently identified specifically impact on different types deaths discuss roles in tumorigenesis.

Language: Английский

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Curcumin nanoformulations to combat aging-related diseases

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 69, P. 101364 - 101364

Published: May 14, 2021

Language: Английский

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Molecular Mechanisms of Melatonin-Mediated Cell Protection and Signaling in Health and Disease

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(2), P. 129 - 129

Published: Jan. 20, 2021

Melatonin, an endogenously synthesized indolamine, is a powerful antioxidant exerting beneficial action in many pathological conditions. Melatonin protects from oxidative stress ischemic/reperfusion injury, neurodegenerative diseases, and aging, decreases inflammation, modulates the immune system, inhibits proliferation, counteracts Warburg effect, promotes apoptosis various cancer models. stimulates enzymes cells, mitochondrial membrane phospholipids, especially cardiolipin, oxidation thus preserving integrity of membranes, affects potential, activity respiratory chain enzymes, opening permeability transition pore cytochrome

Language: Английский

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Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota

Nutrients, Journal Year: 2023, Volume and Issue: 15(7), P. 1767 - 1767

Published: April 4, 2023

Aging is a multi-faceted process caused by the accumulation of cellular damage over time, associated with gradual reduction physiological activities in cells and organs. This degeneration results reduced ability to adapt homeostasis perturbations an increased incidence illnesses such as cognitive decline, neurodegenerative cardiovascular diseases, cancer, diabetes, skeletal muscle pathologies. Key features aging include chronic low-grade inflammation state decrease autophagic process. The Mediterranean diet has been longevity counteract onset age-related disorders. Extra virgin olive oil, fundamental component this diet, contains bioactive polyphenolic compounds hydroxytyrosol (HTyr) oleuropein (OLE), known for their antioxidant, anti-inflammatory, neuroprotective properties. review focused on brain, muscle, gut microbiota, these systems are interact at several levels. After description chemistry pharmacokinetics HTyr OLE, we summarize studies reporting effects vivo vitro models diseases central/peripheral nervous system, adult neurogenesis depression, senescence lifespan, disorders, well impact composition microbiota.

Language: Английский

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Nutritional and lifestyle management of the aging journey: A narrative review

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 24, 2023

With age, the physiological responses to occasional or regular stressors from a broad range of functions tend change and adjust at different pace restoring these in normal healthy becomes increasingly challenging. Even if this natural decline is somehow unavoidable, opportunities exist slow down attenuate impact advancing age on major processes which, when weakened, constitute hallmarks aging. This narrative review revisits current knowledge related aging process its key metabolic including immune, digestive, nervous, musculoskeletal, cardiovascular functions; insights into important biological targets that could inspire effective strategies promote

Language: Английский

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