Aflatoxin B1 Toxicity and Protective Effects of Curcumin: Molecular Mechanisms and Clinical Implications

Antioxidants, Journal Year: 2022, Volume and Issue: 11(10), P. 2031 - 2031

Published: Oct. 14, 2022

One of the most significant classes mycotoxins, aflatoxins (AFTs), can cause a variety detrimental outcomes, including cancer, hepatitis, aberrant mutations, and reproductive issues. Among 21 identified AFTs, aflatoxin B1 (AFB1) is harmful to humans animals. The mechanisms AFB1-induced toxicity are connected generation excess reactive oxygen species (ROS), upregulation CYP450 activities, oxidative stress, lipid peroxidation, apoptosis, mitochondrial dysfunction, autophagy, necrosis, inflammatory response. Several signaling pathways, p53, PI3K/Akt/mTOR, Nrf2/ARE, NF-κB, NLRP3, MAPKs, Wnt/β-catenin have been shown contribute AFB1-mediated toxic effects in mammalian cells. Curcumin, natural product with multiple therapeutic activities (e.g., anti-inflammatory, antioxidant, anticancer, immunoregulation activities), could revise by targeting these pathways. Therefore, potential use curcumin against AFB1-related side underlying molecular summarized. This review, our opinion, advances knowledge, sparks larger discussions, drives additional improvements hazardous examination AFTs detoxifying application curcumin.

Language: Английский

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Exosomes as Promising Nanostructures in Diabetes Mellitus: From Insulin Sensitivity to Ameliorating Diabetic Complications

International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 1229 - 1253

Published: March 1, 2022

Abstract: Diabetes mellitus (DM) is among the chronic metabolic disorders that its incidence rate has shown an increase in developed and wealthy countries due to lifestyle obesity. The treatment of DM always been interest, significant effort made this field. Exosomes belong extracellular vesicles with nanosized features (30– 150 nm) are involved cell-to-cell communication preserving homeostasis. function exosomes different based on their cargo, they may contain lipids, proteins, nucleic acids. present review focuses application DM; both glucose lipid levels significantly affected by exosomes, these nanostructures enhance metabolism decrease deposition. Furthermore, promote affect level glycolytic enzymes transporters DM. Type I results from destruction β cells pancreas, can be employed ameliorate apoptosis endoplasmic reticulum (ER) stress cells. have dual functions mediating insulin resistance/sensitivity, M1 macrophage-derived inhibit secretion. miRNAs, transferring cells, regulate various molecular pathways such as AMPK, PI3K/Akt, β-catenin progression. Noteworthy, body fluids blood circulation, biomarkers for diagnosis diabetic patients. Future studies should focus engineering derived sources mesenchymal stem treat a novel strategy. Keywords: diabetes mellitus, resistance, exosome, uptake, Corrigendum paper published

Language: Английский

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An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 141, P. 111906 - 111906

Published: July 16, 2021

Neurological diseases are responsible for a large number of morbidities and mortalities in the world. Flavonoids phytochemicals that possess various health-promoting impacts. Chrysin, natural flavonoid isolated from diverse fruits, vegetables, even mushrooms, has several pharmacological activities comprising antioxidant, anti-inflammatory, antiapoptotic, anticancer, neuroprotective effects. The current study was designed to review relationship between chrysin administration neurological complications by discussing feasible mechanism signaling pathways. Herein, we mentioned sources, properties, chemistry, drug delivery systems associated with pharmacotherapy. role discussed depression, anxiety, neuroinflammation, Alzheimer's disease, Parkinson's Huntington's epilepsy, cerebral ischemia, spinal cord injury, neuropathy, Multiple Sclerosis, Guillain-Barré Syndrome. findings indicate protective effects against conditions modulating oxidative stress, inflammation, apoptosis animal models. However, more studies should be done clear chrysin.

Language: Английский

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Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Cancer Cell International, Journal Year: 2021, Volume and Issue: 21(1)

Published: April 15, 2021

Abstract Chrysin has been shown to exert several beneficial pharmacological activities. anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well gastrointestinal, respiratory, reproductive, ocular, skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, inflammation. In the current review, we discussed emerging cellular molecular mechanisms underlying therapeutic indications of chrysin various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web Science, search engine Google Scholar were searched for available eligible research articles. The was conducted by using MeSH terms keywords title, abstract, keywords. conclusion, experimental studies indicated that could ameliorate cancers breast, gastrointestinal tract, liver hepatocytes, bladder, male female reproductive systems, choroid, respiratory thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, lymph. However, more are needed enhance bioavailability evaluate this agent clinical trial studies. Graphic abstract

Language: Английский

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Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

Molecules, Journal Year: 2022, Volume and Issue: 27(10), P. 3291 - 3291

Published: May 20, 2022

(1) Background: Dyes play an important role in food, medicine, textile, and other industries, which make human life more colorful. With the increasing demand for food safety, development of natural dyes becomes attractive. (2) Methods: The literature was searched using electronic databases PubMed, Web Science, SciFinder this scoping review carried out following Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA). (3) Results: 248 articles were included review. This summarizes research progress on last ten years. According to structural features, mainly include carotenoids, polyphenols, porphyrins, alkaloids, some newest are summarized. Some pharmacological activities anthocyanin, curcumin, betalains 10 years summarized, biological effects regarding illumination conditions. disadvantages dyes, including sources, cost, stability, poor bioavailability, limit their application. Here, feasible strategies (potential resources, biotechnology, new extraction separation strategies, improving stability) described, will contribute utilization dyes. (4) Conclusion: Natural show health benefits potential additives. However, it is necessary pass toxicity tests quality receive many regulatory approvals before final entry into market as colorants or drugs.

Language: Английский

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Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action

Cellular and Molecular Life Sciences, Journal Year: 2022, Volume and Issue: 79(11)

Published: Oct. 4, 2022

Language: Английский

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The potential role of miRNAs in the pathogenesis of cardiovascular diseases – A focus on signaling pathways interplay

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 248, P. 154624 - 154624

Published: June 17, 2023

Language: Английский

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Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(2), P. 163 - 205

Published: April 18, 2024

Despite their subordination in humans, to a great extent, mitochondria maintain independent status but tightly cooperate with the "host" on protecting joint life quality and minimizing health risks. Under oxidative stress conditions, healthy promptly increase mitophagy level remove damaged "fellows" rejuvenating mitochondrial population sending fragments of mtDNA as SOS signals all systems human body. As long metabolic pathways are under systemic control well-concerted together, adaptive mechanisms become triggered increasing protection, activating antioxidant defense repair machinery. Contextually, attributes patho-/physiology instrumental for predictive medical approach cost-effective treatments tailored individualized patient profiles primary (to protect vulnerable individuals again health-to-disease transition) secondary affected disease progression) care. Nutraceuticals naturally occurring bioactive compounds demonstrating health-promoting, illness-preventing, other health-related benefits. Keeping mind health-promoting properties nutraceuticals along therapeutic potential safety profile, there is permanently growing demand application mitochondria-relevant nutraceuticals. Application beneficial only if meeting needs at individual level. Therefore, risk assessment creation pivotal importance followed by adapted nutraceutical sets needs. Based scientific evidence available nutraceuticals, this article presents examples frequent which require protective measures targeted holistic following advanced concepts predictive, preventive, personalized medicine (PPPM/3PM)

Language: Английский

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Review of the Protective Mechanism of Curcumin on Cardiovascular Disease

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 165 - 192

Published: Jan. 1, 2024

Abstract: Cardiovascular diseases (CVDs) are the most common cause of death worldwide and has been focus research in medical community. Curcumin is a polyphenolic compound extracted from root turmeric. shown to have variety pharmacological properties over past decades. can significantly protect cardiomyocyte injury after ischemia hypoxia, inhibit myocardial hypertrophy fibrosis, improve ventricular remodeling, reduce drug-induced injury, diabetic cardiomyopathy(DCM), alleviate vascular endothelial dysfunction, foam cell formation, smooth muscle cells(VSMCs) proliferation. Clinical studies that curcumin protective effect on blood vessels. Toxicological safe. But high doses also some side effects, such as liver damage defects embryonic heart development. This article reviews mechanism intervention CVDs recent years, order provide reference for development new drugs future. Keywords: curcumin, intima, cells, cell, cardiovascular diseases, inflammation, apoptosis

Language: Английский

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The PI3K/Akt pathway: a target for curcumin’s therapeutic effects

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 17, 2025

Language: Английский

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