Frontiers in Medicine,
Journal Year:
2023,
Volume and Issue:
10
Published: July 3, 2023
Small
noncoding
RNAs,
known
as
microRNAs
(miRNAs),
are
vital
for
the
regulation
of
diverse
biological
processes.
miR-223,
an
evolutionarily
conserved
anti-inflammatory
miRNA
expressed
in
cells
myeloid
lineage,
has
been
implicated
monocyte–macrophage
differentiation,
proinflammatory
responses,
and
recruitment
neutrophils.
The
functions
this
gene
regulated
by
its
expression
levels
or
tissues.
In
review,
we
first
outline
regulatory
role
miR-223
granulocytes,
macrophages,
endothelial
cells,
epithelial
dendritic
(DCs).
Then,
summarize
possible
chronic
obstructive
pulmonary
disease
(COPD),
acute
lung
injury
(ALI),
coronavirus
2019
(COVID-19)
other
inflammatory
diseases
to
better
understand
molecular
networks
diseases.
Frontiers in Genetics,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 6, 2022
MicroRNA-135
(miR-135)
is
a
microRNA
which
involved
in
the
pathoetiology
of
several
neoplastic
and
non-neoplastic
conditions.
Both
tumor
suppressor
oncogenic
roles
have
been
reported
for
this
miRNA.
Studies
prostate,
renal,
gallbladder
nasopharyngeal
cancers
as
well
glioma
shown
down-regulation
miR-135
cancerous
tissues
compared
with
controls.
These
studies
also
impact
on
enhancement
cell
proliferation
aggressive
behavior.
Meanwhile,
has
to
be
up-regulated
bladder,
oral,
colorectal
liver
cancers.
breast,
gastric,
lung
pancreatic
head
neck
squamous
carcinoma
dual
miR-135.
Dysregulation
noted
various
conditions
such
Alzheimer’s
disease,
atherosclerosis,
depression,
diabetes,
Parkinson,
pulmonary
arterial
hypertension,
nephrotic
syndrome,
endometriosis,
epilepsy
allergic
In
current
review,
we
summarize
role
carcinogenesis
development
other
disorders.
Analytical Chemistry,
Journal Year:
2022,
Volume and Issue:
94(3), P. 1787 - 1794
Published: Jan. 12, 2022
Biomimetic
DNA
walking
machines
have
gained
great
success
in
scrutinizing
the
microscopic
world
and
sensitive
biosensing
of
disease
biomarkers.
Despite
superb
achievements,
research
on
for
simultaneous
detection
multiple
analytes
is
still
rare,
while
design
realization
multiplexing
are
considered
as
an
important
bottleneck.
The
multiplex
biomarkers
can
not
only
improve
specificity
bioassays
but
also
avoid
squander
valuable
biological
specimens.
Herein,
we
reported
three-dimensional
(3D)
based
high-resolution
inductively
coupled
plasma
mass
spectrometry
(HR-ICPMS)
lung
cancer-associated
miRNA
detection.
In
presence
target
miRNAs
(miR-21,
miR-141,
miR-125b),
were
stimulated
operated
to
liberate
a
large
number
lanthanide
elements
(Tb,
Ho,
Tm),
then
signals
collected
simultaneously
by
HR-ICPMS.
recovery
test
human
serum
monitoring
experiment
three
cancer
cell
line
(A549)
normal
(HBE)
specimens
display
satisfactory
analysis
capabilities
complex
samples.
Thanks
vast
potential
tags
modular
design,
proposed
bioassay
might
flexibly
detect
different
combinations
with
corresponding
sets
meet
requirements
various
tasks.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(6), P. 5081 - 5081
Published: March 7, 2023
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
rapidly
becoming
one
of
the
leading
causes
cancer-related
deaths
in
United
States,
and
with
its
high
mortality
rate,
there
a
pressing
need
to
develop
sensitive
robust
methods
for
detection.
Exosomal
biomarker
panels
provide
promising
avenue
PDAC
screening
since
exosomes
are
highly
stable
easily
harvested
from
body
fluids.
PDAC-associated
miRNAs
packaged
within
these
could
be
used
as
diagnostic
markers.
We
analyzed
series
18
candidate
via
RT-qPCR
identify
differentially
expressed
(p
<
0.05,
t-test)
between
plasma
patients
control
patients.
From
this
analysis,
we
propose
four-marker
panel
consisting
miR-93-5p,
miR-339-3p,
miR-425-5p,
miR-425-3p
an
area
under
curve
(AUC)
receiver
operator
characteristic
(ROC)
0.885
sensitivity
80%
specificity
94.7%,
which
comparable
CA19-9
standard
marker
diagnostic.
Frontiers in Medicine,
Journal Year:
2023,
Volume and Issue:
10
Published: July 3, 2023
Small
noncoding
RNAs,
known
as
microRNAs
(miRNAs),
are
vital
for
the
regulation
of
diverse
biological
processes.
miR-223,
an
evolutionarily
conserved
anti-inflammatory
miRNA
expressed
in
cells
myeloid
lineage,
has
been
implicated
monocyte–macrophage
differentiation,
proinflammatory
responses,
and
recruitment
neutrophils.
The
functions
this
gene
regulated
by
its
expression
levels
or
tissues.
In
review,
we
first
outline
regulatory
role
miR-223
granulocytes,
macrophages,
endothelial
cells,
epithelial
dendritic
(DCs).
Then,
summarize
possible
chronic
obstructive
pulmonary
disease
(COPD),
acute
lung
injury
(ALI),
coronavirus
2019
(COVID-19)
other
inflammatory
diseases
to
better
understand
molecular
networks
diseases.
