Temperature Induced Gelation and Antimicrobial Properties of Pluronic F127 Based Systems

Polymers, Journal Year: 2023, Volume and Issue: 15(2), P. 355 - 355

Published: Jan. 10, 2023

Different formulations containing Pluronic F127 and polysaccharides (chitosan, sodium alginate, gellan gum, κ-carrageenan) were investigated as potential injectable gels that behave free-flowing liquid with reduced viscosity at low temperatures displayed solid-like properties 37 °C. In addition, ZnO nanoparticles, lysozyme, or curcumin added for testing the antimicrobial of thermal-sensitive gels. Rheological investigations evidenced small changes in transition temperature kinetics gelation °C presence polysaccharides. However, gel formation is very delayed curcumin. The are modest even by adding chitosan, nanoparticles. A remarkable enhancement activity was observed Chitosan addition to Pluronic/curcumin systems improves their viscoelasticity, activity, stability time. balance between viscoelastic characteristics needs be considered formulation suitable biomedical pharmaceutical applications.

Language: Английский

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Curcumin and analogues against head and neck cancer: From drug delivery to molecular mechanisms

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 154986 - 154986

Published: July 21, 2023

Language: Английский

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Curcumin (CUMINUP60®) mitigates exercise fatigue through regulating PI3K/Akt/AMPK/mTOR pathway in mice

Aging, Journal Year: 2023, Volume and Issue: 15(6), P. 2308 - 2320

Published: March 28, 2023

Curcumin is a chemical constituent extracted from Curcuma longa L. Several clinical and preclinical studies have demonstrated that it can mitigate exercise fatigue, but the exact mechanism still unknown. Therefore, we applied mouse model of fatigue to investigate possible molecular mechanisms curcumin’s anti-fatigue effect. Depending on body mass, Kunming mice were randomly divided into control, caffeine (positive drug), curcumin groups, given 28 days intragastric administration. Both group showed significant improvement in compared control group, as evidenced by increase time exhaustion, well higher quadriceps coefficient, muscle glycogen (MG) content, expression Akt, AMPK, PI3K, mTOR proteins. While also significantly improved mice, demonstrating lower AMP/ATP ratio lactic acid (LA) increased synthase (GS), myonectin content group. present study, found exert similar effect may act regulating energy metabolism through modulating proteins PI3K/Akt/AMPK/mTOR pathway.

Language: Английский

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Broadening horizons: ferroptosis as a new target for traumatic brain injury

Burns & Trauma, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 1, 2024

Abstract Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, with ~50 million people experiencing TBI each year. Ferroptosis, form regulated cell triggered by iron ion-catalyzed reactive oxygen species-induced lipid peroxidation, has been identified as potential contributor to traumatic central nervous system conditions, suggesting its involvement in the pathogenesis TBI. Alterations metabolism play crucial role secondary following This study aimed explore ferroptosis TBI, focusing on disorders, disorders regulatory axis Xc−/glutathione/glutathione peroxidase 4 Additionally, we examined chronic stage. Based these findings, discuss therapeutic interventions targeting after In conclusion, this review provides novel insights into pathology proposes targets.

Language: Английский

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Curcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease: a GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials

Nutrition Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 12, 2024

Clinical evidence from investigations of the effects curcumin on liver enzymes in patients with nonalcoholic fatty disease (NAFLD) have led to inconsistent results.

Language: Английский

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