Icariin exhibits protective effects on cisplatin-induced cardiotoxicity via ROS-mediated oxidative stress injury in vivo and in vitro

Phytomedicine, Journal Year: 2022, Volume and Issue: 104, P. 154331 - 154331

Published: July 10, 2022

Language: Английский

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Metabolic Profiling, Chemical Composition, Antioxidant Capacity, and In Vivo Hepato- and Nephroprotective Effects of Sonchus cornutus in Mice Exposed to Cisplatin

Antioxidants, Journal Year: 2022, Volume and Issue: 11(5), P. 819 - 819

Published: April 22, 2022

(Asteraceae) is a wild. edible plant that represents plentiful source of polyphenolic compounds. For the first time, metabolic analysis profiling demonstrated presence anthocyanidin glycosides, coumarins, flavonoids and their corresponding phenolic acids. The total compounds were determined to be 206.28 ± 14.64 mg gallic acid equivalent/gm, while 45.56 1.78 quercetin equivalent/gm. crude extract

Language: Английский

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Natural Products Targeting PI3K/AKT in Myocardial Ischemic Reperfusion Injury: A Scoping Review

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(5), P. 739 - 739

Published: May 12, 2023

This scoping review aimed to summarize the effects of natural products targeting phosphoinositide-3-kinases/serine/threonine kinase (PI3K/AKT) in myocardial ischemia-reperfusion injury (MIRI). The details various types compounds such as gypenoside (GP), XVII (GP-17), geniposide, berberine, dihydroquercetin (DHQ), and tilianin which identified reduce MIRI vitro vivo by regulating PI3K/AKT signaling pathway. In this study, 14 research publications that met inclusion criteria exclusion were shortlisted. Following intervention, we discovered effectively improved cardiac functions through regulation antioxidant status, down-regulation Bax, up-regulation Bcl-2 caspases cleavage. Furthermore, although comparing outcomes can be challenging due heterogeneity study model, results assembled here consistent, giving us confidence intervention’s efficacy. We also discussed if is associated with multiple pathological condition oxidative stress, ERS, mitochondrial injury, inflammation, apoptosis. brief provides evidence support huge potential used treatment their biological activities drug-like properties.

Language: Английский

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The protective effect of 7-hydroxycoumarin against cisplatin-induced liver injury is mediated via attenuation of oxidative stress and inflammation and upregulation of Nrf2/HO-1 pathway

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(33), P. 80181 - 80191

Published: June 9, 2023

Language: Английский

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Tectochrysin Attenuates Cisplatin-induced Hepatotoxicity by Restoring Biochemical, Inflammatory and Histological Profile in Rats

Pakistan Veterinary Journal, Journal Year: 2023, Volume and Issue: 43(02), P. 366 - 370

Published: April 1, 2023

Cisplatin is an efficacious anticancerous chemotherapeutic agent that used to cure multiple types of malignancies. However, it has several hazardous effects on organs, particularly liver. Tectochrysin a naturally occurring flavonoid with extensive pharmacological properties. In this research, the potential anti-oxidant properties tectochrysin against cisplatin-triggered oxidative stress in rats’ hepatic tissues were investigated. 48 male albino rats separated into 4 groups: control cisplatin (10 mg/kg), + mg/kg 5 and (5 mg/kg). The trial executed for one month. biochemical, inflammatory, histopathological liver markers evaluated. results research suggested treatment remarkably lowered activities glutathione (GSH), superoxide dismutase (SOD), reductase (GSR), S-transferase (GST), peroxidase (GPx) as well catalase (CAT) while escalated malondialdehyde (MDA) reactive oxygen species (ROS) levels. administered exhibited significantly higher aspartate aminotransferase (AST), alanine (ALT) alkaline phosphatase (ALP) Furthermore, administration elevated inflammatory indicators i.e., interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) nuclear factor kappa-B (NF- κB) cyclooxygenase-2 (COX-2) activity along impairments. Conversely, co-administration effectively reversed impairments abnormalities tissue rats. current investigation demonstrated cisplatin-induced hepatotoxicity owing its antioxidant, scavenging anti-inflammatory

Language: Английский

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Mcl-1 Protein and Viral Infections: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1138 - 1138

Published: Jan. 17, 2024

MCL-1 is the prosurvival member of Bcl-2 family. It prevents induction mitochondria-dependent apoptosis. The molecular mechanisms dictating host cell viability gain importance in context viral infections. premature apoptosis infected cells could interrupt pathogen replication cycle. On other hand, death following effective assembly progeny particles may facilitate virus dissemination. Thus, various viruses can interfere with regulation network to their advantage. Research has shown that infections affect intracellular amount modify apoptotic potential cells, fitting it “schedule” A growing body evidence suggests virus-dependent deregulation level contribute several virus-driven diseases. In this work, we have described role caused by viruses. We also presented a list promising antiviral agents targeting protein. discussed results indicate targeted interventions addressing anti-apoptotic MCL1 as new therapeutic strategy for cancers well investigation cellular and involved engaging better understanding survival balance.

Language: Английский

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Polygonum minus: A tropical medicinal herb with vast applications in food, agricultural, and medicinal fields

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104511 - 104511

Published: June 10, 2024

Language: Английский

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Eucalyptol Protects against Cisplatin-Induced Liver Injury in Rats

Biology Bulletin, Journal Year: 2023, Volume and Issue: 50(5), P. 987 - 994

Published: Aug. 10, 2023

Language: Английский

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Assessing the ability of polysaccharides extracted from date palm fruit to salvage Wistar rats from cisplatin-linked hepatic damage

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 11, P. 100400 - 100400

Published: Feb. 24, 2024

Cisplatin is a platinum-based chemotherapeutic drug utilized in the treatment of many solid-tissue cancers; it associated with several organ toxicities. For ages, Phoenix Dactylifera, known as " large jujube or dà zǎo," Chinese traditional medicine, has been employed for medicinal applications. The present study assesses role Date Fruit Polysaccharides (DFP) cisplatin-induced liver injury Rats were intraperitoneally treated single therapeutic dose cisplatin (5 mg/kg body weight) and then orally daily without 50/100 weight DFP 7 successive days. salvaging effects assessed on Cisplatin-induced hepatic damage, by investigating function markers, oxidative stress, pro-inflammatory biomarkers, histopathological assessment morphology hematoxylin/eosin stain. To elucidate contents, functional groups, antioxidative potentials DFP, chromatographic, spectroscopic, vitro assays analysed. Exposure to led considerable escalation tested biomarkers (ALP ALT), an upsurge levels/activities malondialdehyde, cytokines, myeloperoxidase significant drop level GSH (P < 0.05) compared control. Moreover, there also obvious decline antioxidant enzymes (catalase, SOD GPx) activities. Contrarily, post-treatment significantly inhibited heightened lipid peroxidation, inflammation, stress dose-dependently. Analysis chemical constituents, activities demonstrated important monosaccharides properties DFP. This shows ability serve probable agent damage treatment.

Language: Английский

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Unraveling the Hidden Potential of Barley (Hordeum vulgare): An Important Review

Plants, Journal Year: 2024, Volume and Issue: 13(17), P. 2421 - 2421

Published: Aug. 30, 2024

Barley (Hordeum vulgare) is a winter crop well known for its small-seeded grains and self-pollinating characteristics. The flour derived from barley plays crucial role in numerous processed food items, contributing to their taste nutritional value. consists of complex carbohydrates (80%), proteins (11.5–14.2%), lipids (4.7–6.8%), β-glucans (3.7–7.7%), ash (1.8–2.4%). Beyond other nutrients, boasts good reservoir phenolic compounds (1.2–2.9 mg/g GAE). This abundance beneficial positions as an attractive industrial substrate. In this review, the composition bioactive profile are discussed systemic manner, emphasizing potential development innovative barley-based products that promote health well-being. By incorporating into various formulations, industries can not only boost content but also offer consumers wide range benefits. conclusion, barley’s diverse applications highlight essential promoting healthier living.

Language: Английский

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