Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
33(4)
Published: Dec. 3, 2022
Abstract
Cancer
is
the
second
leading
cause
of
death
throughout
world.
Nature‐inspired
anticancer
agents
(NAAs)
that
are
a
gift
nature
to
humanity
have
been
extensively
utilized
in
alleviation/prevention
disease
due
their
numerous
pharmacological
activities.
While
oral
route
an
ideal
and
common
way
drug
administration,
application
NAAs
through
pathway
has
extremely
limited
owing
inherent
features,
e.g.,
poor
solubility,
gastrointestinal
(GI)
instability,
low
bioavailability.
With
development
nano‐driven
encapsulation
strategies,
polymeric
vehicles,
especially
those
with
natural
origins,
demonstrated
potent
platform,
which
can
professionally
shield
versatile
against
GI
barricades
safely
deliver
them
site
action.
In
this
review,
predicament
orally
delivering
strategy
solutions
based
on
biopolymer
matrices
summarized.
Proof‐of‐concept
vitro/in
vivo
results
also
discussed
for
delivery
these
by
various
be
found
so
far
from
literature.
Last
but
not
least,
challenges
new
opportunities
field
highlighted.
Gels,
Journal Year:
2024,
Volume and Issue:
10(1), P. 67 - 67
Published: Jan. 16, 2024
The
use
of
fillers
for
soft
tissue
augmentation
is
an
approach
to
restore
the
structure
in
surgically
or
traumatically
created
voids.
Hyaluronic
acid
(HA),
one
main
components
extracellular
matrix,
and
it
widely
employed
design
materials
with
features
similar
human
tissues.
HA-based
already
find
extensive
applications,
but
are
burdened
inherent
drawbacks,
such
as
poor
thermal
stability.
A
well-known
strategy
improve
HA
properties
reticulate
1,4-Butanediol
diglycidyl
ether
(BDDE).
aim
this
work
was
hydrogels
fillers,
by
developing
a
crosslinking
method
carboxymethyl
cellulose
(CMC)
means
BDDE.
CMC
water
soluble
ether,
whose
insertion
into
hydrogel
can
lead
increased
HA/CMC
at
different
ratios
were
prepared,
their
rheological
stability
investigated.
ratio
1/1
resulted
highest
values
viscoelastic
moduli
before
after
treatment.
morphology
examined
via
SEM.
Biocompatibility
response,
performed
Alamar
blue
assay
on
fibroblast
cells,
showed
safety
percentage
around
90%
until
72
h.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(4), P. 2070 - 2085
Published: March 15, 2024
Retinal
diseases,
such
as
age-related
macular
degeneration,
diabetic
retinopathy,
and
retinoblastoma,
stand
the
leading
causes
of
irreversible
vision
impairment
blindness
worldwide.
Effectively
administering
drugs
for
retinal
diseases
poses
a
formidable
challenge
due
to
presence
complex
ocular
barriers
elimination
mechanisms.
Over
time,
various
approaches
have
been
developed
fabricate
drug
delivery
systems
improving
therapy
including
virus
vectors,
lipid
nanoparticles,
polymers.
However,
conventional
nanocarriers
encounter
issues
related
controllability,
efficiency,
safety
in
retina.
Therefore,
development
smart
effective
or
more
invasive
long-term
treatment
remains
desirable
goal.
Recently,
surfaced
intelligent
design
nanocarriers,
leveraging
specific
responses
external
internal
triggers
enabling
multiple
functions
topical
administration,
prolonged
release,
site-specific
delivery.
This
Review
provides
an
overview
prevalent
pathologies
pharmacotherapies
enhance
understanding
diseases.
It
also
surveys
recent
developments
strategies
employed
disease.
Finally,
challenges
potential
clinical
therapeutic
applications
are
discussed
inspire
next
generation
nanocarriers.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
33(4)
Published: Dec. 3, 2022
Abstract
Cancer
is
the
second
leading
cause
of
death
throughout
world.
Nature‐inspired
anticancer
agents
(NAAs)
that
are
a
gift
nature
to
humanity
have
been
extensively
utilized
in
alleviation/prevention
disease
due
their
numerous
pharmacological
activities.
While
oral
route
an
ideal
and
common
way
drug
administration,
application
NAAs
through
pathway
has
extremely
limited
owing
inherent
features,
e.g.,
poor
solubility,
gastrointestinal
(GI)
instability,
low
bioavailability.
With
development
nano‐driven
encapsulation
strategies,
polymeric
vehicles,
especially
those
with
natural
origins,
demonstrated
potent
platform,
which
can
professionally
shield
versatile
against
GI
barricades
safely
deliver
them
site
action.
In
this
review,
predicament
orally
delivering
strategy
solutions
based
on
biopolymer
matrices
summarized.
Proof‐of‐concept
vitro/in
vivo
results
also
discussed
for
delivery
these
by
various
be
found
so
far
from
literature.
Last
but
not
least,
challenges
new
opportunities
field
highlighted.
