Natural plant products as effective alternatives to synthetic chemicals for postharvest fruit storage management DOI

Nahidun Nesa Chowdhury,

Mohammad Nazmul Islam,

Rifat Jafrin

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(30), P. 10332 - 10350

Published: May 25, 2022

Fruits contain enormous source of vitamins that provides energy to the human body. These are also affluent in essential and vital vitamins, minerals, fiber, health-promoting components, which has led an increase fruit consumption recent years. Though expanded considerably years, use synthetic chemicals ripen or store fruits been steadily increasing, resulting postharvest deterioration. Alternatives should be considered control this problem. Instead utilizing chemicals, study suggests using natural plant products decay. The aim indicates how can useful effective eliminate diseases rather than chemicals. Several electronic databases were investigated as information sources, including Google Scholar, PubMed, Web Science, Scopus, ScienceDirect, SpringerLink, Semantic MEDLINE, CNKI Scholar. current review focused on become more necessary because these vast demands fruits. Pathogen-induced main component so portion get wasted after harvest. Besides, it may occur harmful during harvesting subsequent handling, storage, marketing consumer purchasing causes for numerous endogenous exogenous via activating ROS, oxidative stress, lipid peroxidation, etc. However, pathogenicity halted by originating containing bioactive elements responsible management nutritional deficiency, inflammation, cancer, on. issues arising must controlled resolved before releasing horticultural commodities commercialization. Therefore, pathogens still depends fungicides; however, due problem development fungicide-resistant strains there is a good demand public eradicate pesticides with arrival their intensity specific chemical product. By organic controlling mandatory step take. In addition, antimicrobial packaging have greater impact long-term food security lowering risk increasing longevity shelf life. Taken together, acetaldehyde, hexanal, eugenol, linalool, jasmonates, glucosinolates, oils, many reported combating illnesses guide way storage review.

Language: Английский

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect DOI Creative Commons
Huiyang Liu, Xiaomei Zhang, Peng Shi

et al.

Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: March 27, 2023

Abstract Depression is a common mental illness, which related to monoamine neurotransmitters and the dysfunction of cholinergic, immune, glutamatergic, neuroendocrine systems. The hypothesis one commonly recognized pathogenic mechanisms depression; however, drugs designed based on this have not achieved good clinical results. A recent study demonstrated that depression inflammation were strongly correlated, activation alpha7 nicotinic acetylcholine receptor (α7 nAChR)-mediated cholinergic anti-inflammatory pathway (CAP) in system exhibited therapeutic effects against depression. Therefore, anti-inflammation might be potential direction for treatment Moreover, it also necessary further reveal key role α7 nAChR pathogenesis This review focused correlations between as well-discussed crucial CAP.

Language: Английский

Citations

28
Advances in Brain–Gut–Microbiome Interactions: A Comprehensive Update on Signaling Mechanisms, Disorders, and Therapeutic Implications DOI Creative Commons
Tien S. Dong, Emeran A. Mayer

Cellular and Molecular Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: 18(1), P. 1 - 13

Published: Jan. 1, 2024

Significant strides have been made in brain-gut-microbiome research over the past six years, fueled by technological breakthroughs and discovery of new mechanistic pathways.

Language: Английский

Citations

14
Apple polyphenol extract ameliorates sugary-diet-induced depression-like behaviors in male C57BL/6 mice by inhibiting the inflammation of the gut–brain axis DOI

Yisha Xie,

Zhengli Wu,

Qingfan Qian

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(6), P. 2939 - 2959

Published: Jan. 1, 2024

C57BL/6 mice were fed with control diet, sugary-diet, or sugary-diet APE gavage for 8 weeks. After behavioral testing, the samples of serum, hippocampus, colon, and colonic contents collected further determination.

Language: Английский

Citations

10
Midbrain organoids for Parkinson's disease (PD) - A powerful tool to understand the disease pathogenesis DOI

Harysh Winster Suresh Babu,

Sindduja Muthu Kumar,

Harsimrat Kaur

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 345, P. 122610 - 122610

Published: April 4, 2024

Language: Английский

Citations

9
Widely targeted metabolomic analysis reveals metabolite changes induced by incorporating black tea fermentation techniques in oolong tea processing for quality improvement DOI

Mengjiao Hao,

Xingfei Lai,

Qiuhua Li

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 459, P. 140433 - 140433

Published: July 11, 2024

Language: Английский

Citations

9
Natural drug delivery systems for the treatment of neurodegenerative diseases DOI
Greta Kaspute, Arūnas Ramanavičius,

Urtė Prentice

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 10, 2025

Language: Английский

Citations

1
Valorization of Food Processing Waste to Produce Valuable Polyphenolics DOI

Yuyin Chang,

Xiaoyu Shi, Fei He

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(29), P. 8855 - 8870

Published: July 14, 2022

Traditional incineration and landfill of food processing waste (FPW) have polluted the environment underutilized valuable bioactive compounds, including polyphenols in waste. As one most widely occurring compounds FPW, possess high utilization value many fields such as human health, energy, environmental protection. Extracting directly from FPW can maximize avoid resources. However, traditional polyphenol extraction methods mostly use Soxhlet extraction, infiltration, impregnation method, consuming a large amount organic solvent suffering long time low efficiency. Emerging green supercritical fluid ultrasonic-assisted microwave-assisted other shorten improve efficacy, resulting safe recovery FPW. In this paper, treatment application are briefly reviewed, emerging compared to obtain insight into start-of-the-art approaches.

Language: Английский

Citations

34
Phytochemical Profiling, Antioxidant, Anti-Inflammatory, Thrombolytic, Hemolytic Activity In Vitro and In Silico Potential of Portulacaria afra DOI Creative Commons
Sobia Tabassum, Saeed Ahmad, Kashif-ur-Rehman Khan

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(8), P. 2377 - 2377

Published: April 7, 2022

The use of complementary herbal medicines has recently increased in an attempt to find effective alternative therapies that reduce the adverse effects chemical drugs. Portulacaria afra is a rich source phytochemicals with high antioxidant activity, and thus may possess health benefits. This study used latest developments GC-MS coupling molecular docking techniques identify quantify phytoconstituents P. tissue extracts. results revealed n-butanol (BUT-PA) dry extracts contained total phenolic flavonoids contents 21.69 ± 0.28 mgGAE/g 196.58 6.29 mgGAE/g, respectively. significant potential antioxidants was observed through CUPRIC, FRAP, ABTS methods while DPPH method showed moderate for afra. Enzymatic antioxidants, superoxide dismutase, peroxidase catalase also better response BUT-PA thrombolytic activity ranged from 0.4 0.32 11.2 0.05%. Similarly, hemolytic 5.76 0.15 9.26 0.15% using standard (triton x) method. BUTPA CHPA acetylcholinesterase butrylcholinesterase inhibition, ranging 40.78 0.52 58.97 0.33, compared galantamine. carrageenan induced hind-paw edema assay, anti-inflammatory properties dose-dependent manner. Furthermore, 20 compounds were identified by GC-MS. Molecular performed explore synergistic effect GC-MS-identified on COX-1 COX-2 inhibition. A binding affinity Stigmastan-3, 5-diene, Phthalic acid, 3. Alpha-Hydroxy-5, 16-androstenol. computed energies all have effect, preventing inflammation. It concluded active present afra, multiple pharmacological applications as latent pharmaceutically important compounds. should be further explored isolate secondary metabolites can employed treatment different diseases.

Language: Английский

Citations

30
Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from Lonicera japonica Thunb.: A Review DOI Creative Commons

Xinpeng Yang,

Aiqi Yu,

Wenjing Hu

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(12), P. 4828 - 4828

Published: June 17, 2023

Lonicera japonica Thunb. is a widely distributed plant with ornamental, economic, edible, and medicinal values. L. phytoantibiotic broad-spectrum antibacterial activity potent therapeutic effect on various infectious diseases. The anti-diabetic, anti-Alzheimer’s disease, anti-depression, antioxidative, immunoregulatory, anti-tumor, anti-inflammatory, anti-allergic, anti-gout, anti-alcohol-addiction effects of can also be explained by bioactive polysaccharides isolated from this plant. Several researchers have determined the molecular weight, chemical structure, monosaccharide composition ratio water extraction alcohol precipitation, enzyme-assisted (EAE) chromatography. This article searched in Chinese Pharmacopoeia, Flora China, Web Science, PubMed, CNKI databases within last 12 years, using “Lonicera. polysaccharides”, “Honeysuckle polysaccharides” as key word, systematically reviewed purification methods, structural characteristics, structure-activity relationship, health benefits to provide insights for future studies. Further, we elaborated potential applications food, medicine, daily industry, such raw material make lozenges, soy sauce toothpaste, etc. review will useful reference further optimization functional products developed polysaccharides.

Language: Английский

Citations

17
Anti-neuroinflammatory effect of hydroxytyrosol: a potential strategy for anti-depressant development DOI Creative Commons
Shuaiguang Li,

Huarong Shao,

Ting Sun

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: March 1, 2024

Introduction: Depression is a complex psychiatric disorder with substantial societal impact. While current antidepressants offer moderate efficacy, their adverse effects and limited understanding of depression’s pathophysiology hinder the development more effective treatments. Amidst this complexity, role neuroinflammation, recognized but poorly understood associate depression, has gained increasing attention. This study investigates hydroxytyrosol (HT), an olive-derived phenolic antioxidant, for its antidepressant anti-neuroinflammatory properties based on mitochondrial protection. Methods: In vitro studies neuronal injury models, protective effect HT ultrastructure from inflammatory damage was investigated in combination high-resolution imaging substructures. animal depressive-like behaviors chronic restraint stress (CRS) mice unpredictable mild (CUMS) rats were examined to investigate alleviating HT. Targeted metabolomics RNA-Seq CUMS used analyze potential pathways Results: protected damage, thus exerting neuroprotective models. Moreover, reduced exposed CRS CUMS, respectively. HT’s influence model included hippocampal modulating cytokine production, dysfunction, brain-derived neurotrophic factor (BDNF) signaling. revealed neurotransmitter levels tryptophan-kynurenine metabolism. data underscored mechanism through BDNF/TrkB signaling pathways, key nerve fiber functions, myelin formation, microglial differentiation, neural regeneration. Discussion: The findings underscore as treatment shedding light relevance nutritional psychiatry. Further investigations are warranted comprehensively delineate mechanisms optimize clinical application depression treatment.

Language: Английский

Citations

7