Cinnamaldehyde protects donor heart from cold ischemia–reperfusion injury via the PI3K/AKT/mTOR pathway

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 114867 - 114867

Published: June 28, 2023

With the growing shortage of organs, improvements in donor organ protection are needed to meet increasing demands for transplantation. Here, aim was investigate protective effect cinnamaldehyde against ischemia-reperfusion injury (IRI) hearts exposed prolonged cold ischemia. Donor were harvested from rats pretreated with or without cinnamaldehyde, then subjected 24 h preservation and 1 ex vivo perfusion. Hemodynamic changes, myocardial inflammation, oxidative stress, apoptosis evaluated. The PI3K/AKT/mTOR pathway involved cardioprotective effects explored through RNA sequencing western blot analysis. Intriguingly, pretreatment remarkably improved cardiac function coronary flow, left ventricular systolic pressure, +dp/dtmax, -dp/dtmax, decreasing vascular resistance end-diastolic pressure. Moreover, our findings indicated that protected heart IRI by alleviating attenuating reducing apoptosis. Further studies showed activated after treatment during IRI. abolished LY294002. In conclusion, alleviated suffering Cinnamaldehyde exerted activation pathway.

Language: Английский

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The role and mechanism of cinnamaldehyde in cancer

Journal of Food and Drug Analysis, Journal Year: 2024, Volume and Issue: 32(2), P. 146 - 160

Published: June 10, 2024

As cancer continues to rise globally, there is growing interest in discovering novel methods for prevention and treatment. Due the limitations of traditional therapies, has been a emphasis on investigating herbal remedies exploring their potential synergistic effects when combined with chemotherapy drugs. Cinnamaldehyde, derived from cinnamon, gained significant attention its role Extensive research demonstrated that cinnamaldehyde exhibits promising anticancer properties by modulating various cellular processes involved tumor growth progression. However, challenges unanswered questions remain regarding precise mechanisms effective use as an agent. This article aims explore multifaceted cells shed light these existing issues. Cinnamaldehyde diverse anti-cancer mechanisms, including inducing apoptosis activating caspases damaging mitochondrial function, inhibiting angiogenesis, anti-proliferation, anti-inflammatory antioxidant. In addition, also acts reactive oxygen species scavenger, reducing oxidative stress preventing DNA damage genomic instability. emphasizes therapeutic treatment underscores need future unlock strategies combating cancer. By providing valuable insights into mechanism cancer, this comprehensive understanding paves way Overall, holds great promise agent, exploration highlights addition options.

Language: Английский

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Protective Effects of Trans-Chalcone on Myocardial Ischemia and Reperfusion Challenge through Targeting Phosphoinositide 3-kinase/Akt-inflammosome Interaction

Journal of physiological investigation., Journal Year: 2024, Volume and Issue: 67(3), P. 129 - 138

Published: May 1, 2024

Ischemia-reperfusion (IR) injury remains a pivotal contributor to myocardial damage following acute coronary events and revascularization procedures. Phosphoinositide 3-kinase (PI3K), key mediator of cell survival signaling, plays central role in regulating inflammatory responses death mechanisms. Trans-chalcone (Tch), natural compound known for its anti-inflammatory activities, has shown promise various disease models. The aim the current study was investigate potential protective effects Tch against induced by ischemia reperfusion challenges targeting PI3K-inflammasome interaction. Experimental models utilizing male rats subjected an vivo model IR infarction were employed. Administration (100 μg/kg, intraperitoneally) significantly reduced injury, as indicated limited infarct size decreased levels enzyme troponin. Mechanistically, upregulated PI3K expression, thereby inhibiting activity NOD-like receptor protein 3 inflammasome followed activation pro-inflammatory cytokines interleukin-1β (IL-1β) IL-18. Moreover, it mitigated oxidative stress suppressed vascular-intercellular adhesion molecules, contributing cardioprotective effects. PI3K/Akt pathway inhibitor LY294002 considerably attenuated beneficial Tch. These findings highlight therapeutic ameliorating associated with insults through modulation PI3K/Akt-inflammasome axis. multifaceted mechanisms underlying signify promising candidate further exploration developing targeted therapies aimed at mitigating ischemic heart improving clinical outcomes cardiovascular diseases characterized injury.

Language: Английский

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The Therapeutic Roles of Cinnamaldehyde against Cardiovascular Diseases

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 23

Published: Oct. 8, 2022

Evidence from epidemiological studies has demonstrated that the incidence and mortality of cardiovascular diseases (CVDs) increase year by year, which pose a great threat on social economy human health worldwide. Due to limited therapeutic benefits associated adverse effects current medications, there is an urgent need uncover novel agents with favorable safety efficacy. Cinnamaldehyde (CA) bioactive phytochemical isolated stem bark Chinese herbal medicine Cinnamon been suggested possess curative roles against development CVDs. This integrated review intends summarize physicochemical pharmacokinetic features CA discuss recent advances in underlying mechanisms potential targets responsible for anti-CVD properties CA. The CA-related protective could be attributed inhibition inflammation oxidative stress, improvement lipid glucose metabolism, regulation cell proliferation apoptosis, suppression cardiac fibrosis, platelet aggregation promotion vasodilation angiogenesis. Furthermore, likely inhibit CVD progression via affecting other possible processes including autophagy ER stress regulation, gut microbiota immune homeostasis, ion ncRNA expression, TRPA1 activation. Collectively, experiments reported previously highlight clinical trials are advocated offer scientific basis compound future applied practice prophylaxis treatment.

Language: Английский

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Carbon Dots Derived from Curcumae Radix and Their Heartprotective Effect

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3315 - 3332

Published: April 1, 2024

Background: Acute myocardial infarction (AMI) is a common cardiovascular disease in clinic.Currently, there no specific treatment for AMI.Carbon dots (CDs) have been reported to show excellent biological activities, which hold promise the development of novel nanomedicines diseases.Methods: In this study, we firstly prepared CDs from natural herb Curcumae Radix Carbonisata (CRC-CDs) by green, simple calcination method.The aim study investigate cardioprotective effect and mechanism CRC-CDs on isoproterenol (ISO) -induced (MI) rats. Results:The results showed that pretreatment with significantly reduced serum levels cardiac enzymes (CK-MB, LDH, AST) lipids (TC, TG, LDL) st-segment elevation infarct size ECG AMI rats.Importantly, ejection fraction (EF) shortening (FS) were markedly elevated, as was ATPase activity.In addition, could increase superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), reduce malondialdehyde (MDA) reactive oxygen species (ROS) tissue, thereby exerting enhancing antioxidant capacity tissue.Moreover, TUNEL staining image positive apoptotic cells declined after treatment, indicate inhibit cardiomyocyte apoptosis.Importantly, The protective H 2 O -pretreated H9c2 also verified vitro.Conclusion: Taken together, has potential clinical application an anti-myocardial ischemia drug candidate, not only provides evidence further broadening diseases, but offers hope nanomedicine treat intractable diseases.

Language: Английский

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Regulatory Role of Bioactive Compounds from Natural Spices on Mitochondrial Function

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Natural spices have gained much attention for their aromatic and pungent flavors as well multiple beneficial health effects. As complex organelles that play a central role in energy production, stress response control, cell signal transduction, metabolism regulation, mitochondria could be regulated by many bioactive components spices. In this review, the of maintaining cellular homeostasis is summarized. The regulatory effects mitochondrial function major compounds from natural are evaluated, including capsaicin, 6-gingerol, 6-shogaol, allicin, quercetin, curcumin, tetrahydrocurcumin, cinnamaldehyde. underlying molecular mechanisms also discussed. This work enhance our understanding toward health-promoting properties spice provide new insights into prevention treatment disorders associated with dysfunctions those nutraceuticals.

Language: Английский

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The Protective Role of Cinnamaldehyde in Kidney Injury: Modulation of NF-κB and PI3K/Akt Signaling Pathways

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2025, Volume and Issue: 4(1), P. 132 - 141

Published: Feb. 28, 2025

Chronic renal disease is defined as the presence of kidney damage or impaired function over a period at least three months, regardless origin condition. Numerous factors, including oxidative stress, inflammation, and cell death, are frequently responsible for acute chronic injury, which significant issue in field global health. Because crucial functions that they play, NF-κB PI3K/Akt signaling pathways potential therapeutic targets. These pathogenic processes mediated by these pathways. cinnamonaldehyde, naturally occurring bioactive component, has demonstrated encouraging nephroprotective properties. properties attributed to fact it contains anti-inflammatory, antioxidant, anti-apoptotic The purpose this review investigate molecular role cinnamaldehyde preventing modulating Within article, we examine involved highlight treatment disease. Although preclinical studies have protective effects, additional research, clinical trials, required validate its safety, effectiveness, uses management illness people.

Language: Английский

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Advances in detecting fruit aroma compounds by combining chromatography and spectrometry

Journal of the Science of Food and Agriculture, Journal Year: 2023, Volume and Issue: 103(10), P. 4755 - 4766

Published: Feb. 14, 2023

Fruit aroma is produced by volatile compounds, which can significantly enhance fruit flavor. These compounds are highly complex and have remarkable pharmacological effects. The synthesis, concentration, type, quantity of substances affected various factors, both abiotic biotic. To fully understand the fruits their influencing detection technology be used. Many methods exist for detecting approaches combining multiple instruments widely This review describes compares each discusses potential use combined technologies to provide a comprehensive understanding factors synthesis. results inform development utilization substances. © 2023 Society Chemical Industry.

Language: Английский

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Biological fate, functional properties, and design strategies for oral delivery systems for cinnamaldehyde

Food & Function, Journal Year: 2024, Volume and Issue: 15(12), P. 6217 - 6231

Published: Jan. 1, 2024

Cinnamaldehyde (CA) is the main bioactive component extracted from internal bark of cinnamon trees with many health benefits. In this paper, bioavailability and biological activities cinnamaldehyde, underlying molecular mechanism are reviewed discussed, including antioxidant, cardioprotective, anti-inflammatory, anti-obesity, anticancer, antibacterial properties. Common delivery systems that could improve stability CA also summarized evaluated, such as micelles, microcapsules, liposomes, nanoparticles, nanoemulsions. This work provides a comprehensive understanding beneficial functions strategies CA, which useful for future application in functional food industry.

Language: Английский

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Design and Synthesis of Coumarin Derivatives as Cytotoxic Agents through PI3K/AKT Signaling Pathway Inhibition in HL60 and HepG2 Cancer Cells

Molecules, Journal Year: 2022, Volume and Issue: 27(19), P. 6709 - 6709

Published: Oct. 9, 2022

In this study, a series of coumarin derivatives, either alone or as hybrids with cinnamic acid, were synthesized and evaluated for their cytotoxicity against panel cancer cells using the MTT assay. Then, most active compounds inspected mechanism by cell-cycle analysis, RT-PCR, DNA fragmentation, Western blotting techniques. Cytotoxic results showed that compound (4) had significant cytotoxic effect HL60 (IC50 = 8.09 µM), while (8b) noticeable activity HepG2 13.14 µM). Compounds mediated via PI3K/AKT pathway inhibition. These assured molecular docking studies. support further exploratory research focusing on therapeutic derivatives agents.

Language: Английский

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