Explore the protein targets of Cinnamomum zeylanicum’s phytoconstituents against pathogenic Staphylococcus aureus: GC-MS profiling, molecular docking, pharmacophore, and pathway reconstruction DOI Creative Commons
Sarit Prabha, Sudeesh Warkare,

Akash Ranga

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract Staphylococcus aureus is a leading cause of severe infections, including sepsis, due to its diverse virulence factors. Alternative treatments are essential because the side effects and resistance linked conventional therapies. Medicinal plants like Cinnamomum zeylanicum, rich in secondary metabolites, potential alternatives. This study explores antimicrobial target protein interaction pathway C. zeylanicum bark against pathogenic S. aureus. Methanolic extraction C. zeylanicum was followed by qualitative quantitative screening GC-MS analysis detect phytoconstituents. The minimum inhibitory concentration (MIC) bactericidal (MBC) were evaluated aureus; additionally, assessed PCR plc, icaA, nuc genes. In silico included molecular docking, pharmacophore, ADMET identified compounds seven proteins. PCA docking conducted generated tetrapartite network using string KEGG database. methanolic crude extract, containing 19 phytoconstituents, showed significant MIC MBC value as 5mg/mL. revealed that phytoconstituents alfa-copaene, alpha-muurolene, tau-cadinol inhibitors, displaying favourable binding interactions with proteins D-alanine-D-alanine ligase, dihydrofolate reductase, peptide deformylase, penicillin-binding 2. Protein suggest inhibiting can disrupt processes cell wall formation, DNA replication, synthesis. contains phenol flavonoid-derived inhibit Further studies needed fully evaluate therapeutic for infection treatment.

Language: Английский

The Protective Role of Cinnamaldehyde in Kidney Injury: Modulation of NF-κB and PI3K/Akt Signaling Pathways DOI
Sachit Sharma,

Astha Sharma,

Sandip Tejpal

et al.

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2025, Volume and Issue: 4(1), P. 132 - 141

Published: Feb. 28, 2025

Chronic renal disease is defined as the presence of kidney damage or impaired function over a period at least three months, regardless origin condition. Numerous factors, including oxidative stress, inflammation, and cell death, are frequently responsible for acute chronic injury, which significant issue in field global health. Because crucial functions that they play, NF-κB PI3K/Akt signaling pathways potential therapeutic targets. These pathogenic processes mediated by these pathways. cinnamonaldehyde, naturally occurring bioactive component, has demonstrated encouraging nephroprotective properties. properties attributed to fact it contains anti-inflammatory, antioxidant, anti-apoptotic The purpose this review investigate molecular role cinnamaldehyde preventing modulating Within article, we examine involved highlight treatment disease. Although preclinical studies have protective effects, additional research, clinical trials, required validate its safety, effectiveness, uses management illness people.

Language: Английский

Citations

0
Integrative approach to decipher pharmacological mechanism of Cinnamomum zeylanicum essential oil in prostate cancer DOI

Debajani Mohanty,

Sucheesmita Padhee,

Arpita Priyadarshini

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 12, 2025

Language: Английский

Citations

0
Unravelling the antitumor mechanism of Ocoxin through cancer cell genomics DOI Creative Commons
Iera Hernandez-Unzueta,

Uxue Telleria-Gonzalez,

Ana M. Aransay

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Cancer is one of the leading causes death worldwide. Many therapies are being used to treat this disease, however, new treatments now implemented, since they not always effective and their secondary effects represent main reasons for cancer patients’ loss life quality during progression disease. In scenario, Ocoxin a mixture plant extracts, amino acids, vitamins minerals, known its antioxidant, anti-inflammatory immunoregulatory properties, which has shown exert antitumor in many cancers. The aim study elucidate mechanism action compound colorectal cancer, triple negative breast pancreatic prostate cancer. Analyses performed through RNA sequencing revealed that effect appears be alteration cell metabolism, especially inducing process ferroptosis. Nevertheless, modulation cycle was also remarkable. altered 13 genes common all four cancers were only associated metabolism but involved integrated stress response unfolded protein response, suggesting induction several pathways. Although mechanisms vary according type highlights potential as an adjunctive treatment improve outcomes therapy.

Language: Английский

Citations

0
Liposome-assisted combination chemotherapy improves the anti-proliferation and anti-angiogenesis response of cisplatin in breast cancer; experimental and computational study DOI

Nasim Valinezhadi,

Gholamreza Dehghan, Mohammad Yaghoubzad-Maleki

et al.

Journal of Chemotherapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: April 15, 2025

AbstractCombination chemotherapy using liposomes offers a promising approach to overcome resistance and minimize side effects in breast cancer treatment. This study explores the synergistic of all-trans-retinoic acid (ATRA) cinnamaldehyde (CA) combined with cisplatin (CPT) MDA-MB-231 cells. The liposomal formulation, CPT_ATRA_CA, significantly reduced cell proliferation 25.9 ± 2.8% compared controls effectively inhibited angiogenesis. Additionally, it induced apoptosis, as demonstrated by flow cytometry, DAPI staining, an elevated Bax/Bcl-2 gene expression ratio. Computational analysis via molecular docking dynamics simulation revealed that ATRA exhibited highest binding affinity for angiogenin (ANG) energy -106.072 kcal/mol. Experimental results, corroborated computational data, highlight potent anti-tumor this drug trio. These findings suggest delivery ATRA, CA, CPT could enhance therapeutic outcomes targeting multiple pathways synergistically.

Language: Английский

Citations

0
Antioxidant Role of Probiotics in Inflammation-Induced Colorectal Cancer DOI Open Access
Sevag Hamamah, Andrei Lobiuc, Mihai Covașă

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9026 - 9026

Published: Aug. 20, 2024

Colorectal cancer (CRC) continues to be a significant contributor global morbidity and mortality. Emerging evidence indicates that disturbances in gut microbial composition, the formation of reactive oxygen species (ROS), resulting inflammation can lead DNA damage, driving pathogenesis progression CRC. Notably, bacterial metabolites either protect against or contribute oxidative stress by modulating activity antioxidant enzymes influencing signaling pathways govern ROS-induced inflammation. Additionally, microbiota byproducts, when supplemented through probiotics, affect tumor microenvironments enhance treatment efficacy selectively mediate destruction CRC cells. This review aims discuss mechanisms which taxonomical shifts related such as short-chain fatty acids, secondary bile trimethylamine-N-oxide influence ROS concentrations safeguard promote onset inflammation-mediated we focus on role probiotic ROS-mediated both status inflammation, Nrf2-Keap1, NF-κB, NLRP3 mitigate carcinogenesis. Overall, deeper understanding may aid delaying preventing offer new avenues for adjunct, CRC-specific therapeutic interventions immunotherapy.

Language: Английский

Citations

3
The therapeutic perspective of cinnamon (Cinnamomum verum) consumption against metabolic syndrome DOI Creative Commons
Tehmina Bibi, Ammar B. Altemimi, Roshina Rabail

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 122, P. 106545 - 106545

Published: Nov. 1, 2024

Language: Английский

Citations

1
Explore the protein targets of Cinnamomum zeylanicum’s phytoconstituents against pathogenic Staphylococcus aureus: GC-MS profiling, molecular docking, pharmacophore, and pathway reconstruction DOI Creative Commons
Sarit Prabha, Sudeesh Warkare,

Akash Ranga

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract Staphylococcus aureus is a leading cause of severe infections, including sepsis, due to its diverse virulence factors. Alternative treatments are essential because the side effects and resistance linked conventional therapies. Medicinal plants like Cinnamomum zeylanicum, rich in secondary metabolites, potential alternatives. This study explores antimicrobial target protein interaction pathway C. zeylanicum bark against pathogenic S. aureus. Methanolic extraction C. zeylanicum was followed by qualitative quantitative screening GC-MS analysis detect phytoconstituents. The minimum inhibitory concentration (MIC) bactericidal (MBC) were evaluated aureus; additionally, assessed PCR plc, icaA, nuc genes. In silico included molecular docking, pharmacophore, ADMET identified compounds seven proteins. PCA docking conducted generated tetrapartite network using string KEGG database. methanolic crude extract, containing 19 phytoconstituents, showed significant MIC MBC value as 5mg/mL. revealed that phytoconstituents alfa-copaene, alpha-muurolene, tau-cadinol inhibitors, displaying favourable binding interactions with proteins D-alanine-D-alanine ligase, dihydrofolate reductase, peptide deformylase, penicillin-binding 2. Protein suggest inhibiting can disrupt processes cell wall formation, DNA replication, synthesis. contains phenol flavonoid-derived inhibit Further studies needed fully evaluate therapeutic for infection treatment.

Language: Английский

Citations

0