Nanoparticle-based therapeutic approaches for wound healing: a review of the state-of-the-art

Materials Today Chemistry, Journal Year: 2022, Volume and Issue: 27, P. 101319 - 101319

Published: Dec. 21, 2022

Language: Английский

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Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 266, P. 110985 - 110985

Published: Sept. 9, 2023

Language: Английский

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An injectable photo-cross-linking silk hydrogel system augments diabetic wound healing in orthopaedic surgery through spatiotemporal immunomodulation

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: May 14, 2022

The complicated hyperglycaemic and chronic inflammation of diabetic wounds in orthopaedic surgery leads to dysregulated immune cell function potential infection risk. Immune interventions face a possible contradiction between simultaneous establishment the pro-inflammatory microenvironment response bacterial invasion anti-inflammatory required for tissue repair. To study this accelerate diabetic-wound healing, we developed photocurable methacryloxylated silk fibroin hydrogel (Sil-MA) system, co-encapsulated with metformin-loaded mesoporous silica microspheres (MET@MSNs) silver nanoparticles (Ag NPs).The system (M@M-Ag-Sil-MA) enhanced healing via spatiotemporal immunomodulation. Sil-MA imparts rapid situ Ultra-Violet-photocurable capability allows preliminary controlled release Ag NPs, which can inhibit aggregation create stable, sterile microenvironment. results confirmed involvement Met immunomodulatory effects following dual-controlled Sil-MA. Hysteresis-released from shifts M1 phenotype macrophages regions trauma an M2 phenotype. Simultaneously, M@M-Ag-Sil-MA inhibited formation neutrophil extracellular traps (NETs) decreased elastase, myeloperoxidase, NETs-induced factors. As result modulating microenvironmental, promoted fibroblast migration endothelial angiogenesis vivo, verification accompanied immunoregulation NETs mouse model.Our findings demonstrated that resolved through immunomodulation NETs, suggesting its as promising engineered nano-dressing treatment surgery.

Language: Английский

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Phytoconstituents as modulators of NF-κB signalling: Investigating therapeutic potential for diabetic wound healing

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117058 - 117058

Published: July 4, 2024

The NF-κB pathway plays a pivotal role in impeding the diabetic wound healing process, contributing to prolonged inflammation, diminished angiogenesis, and reduced proliferation. In contrast modern synthetic therapies, naturally occurring phytoconstituents are well-studied inhibitors of that now attracting increased attention context because lower toxicity, better safety efficacy, cost-effectiveness. This study explores recent research on phytoconstituent-based therapies delve into their action mechanisms targeting potential for assisting effective wounds. For this purpose, we have carried out surveys literature analyzed studies from prominent databases such as Science Direct, Scopus, PubMed, Google Scholar, EMBASE, Web Science. classification various categorie as: alkaloids, triterpenoids, phenolics, polyphenols, flavonoids, monoterpene glycosides, naphthoquinones tocopherols. Noteworthy phytoconstituents, including Neferine, Plumbagin, Boswellic acid, Genistein, Luteolin, Kirenol, Rutin, Vicenin-2, Gamma-tocopherol, Icariin, Resveratrol, Mangiferin, Betulinic Berberine, Syringic Gallocatechin, Curcumin, Loureirin-A, Loureirin-B, Lupeol, Paeoniflorin, Puerarin emerge these promising agents through inhibition pathway. Extensive has revealed how they modulate signalling pathways, NF-κB, demonstrate development therapeutic assist chronic

Language: Английский

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Gas Therapy: Generating, Delivery, and Biomedical Applications

Small Methods, Journal Year: 2024, Volume and Issue: 8(8)

Published: Jan. 9, 2024

Abstract Oxygen (O 2 ), nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H S), and ) with direct effects, dioxide (CO complementary effects on the condition of various diseases are known as therapeutic gases. The targeted delivery in situ generation these gases controllable release at site disease has attracted attention to avoid risk gas poisoning improve their performance treating such cancer therapy, cardiovascular bone tissue engineering, wound healing. Stimuli‐responsive gas‐generating sources systems based biomaterials that enable on‐demand promising approaches for precise therapy. This work highlights current advances design development new generate deliver behavior. delivered biomedical applications is then discussed.

Language: Английский

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Advances in the Regulation of Inflammatory Mediators in Nitric Oxide Synthase: Implications for Disease Modulation and Therapeutic Approaches

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1204 - 1204

Published: Jan. 30, 2025

Nitric oxide synthases (NOS) are crucial enzymes responsible for the production of nitric (NO), a signaling molecule with essential roles in vascular regulation, immune defense, and neurotransmission. The three NOS isoforms, endothelial (eNOS), neuronal (nNOS), inducible (iNOS), tightly regulated by inflammatory mediators cellular pathways. While physiological NO is vital maintaining homeostasis, dysregulated activity contributes to pathogenesis numerous diseases, including cardiovascular disorders, neurodegenerative conditions, cancer. Recent advances understanding molecular mechanisms regulation have unveiled novel therapeutic opportunities, isoform-specific modulators, upstream pathways, nanotechnology-enhanced delivery systems. This review highlights these advancements, offering insights into how targeting its regulatory network can enable precise effective strategies managing inflammation-driven pathologies.

Language: Английский

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Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 29, 2025

The challenges associated with prolonged healing or non-healing of chronic diabetic wounds contribute significantly to the increased incidence lower limb amputation. A pivotal factor in impediment is reduced production endogenous nitric oxide (NO) due hyperglycemic microenvironment typical diabetes. While both and exogenous NO have been shown promote process wounds, direct application wound management limited its gaseous nature risk explosive release. This review summarizes recent advances nanodressings incorporating donors treatment detailing specific conditions under which these facilitate release, a focus on beneficial effects NO, strategies for supplementation, encountered clinical translation as clinically viable nanomedicine context improving healing.

Language: Английский

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Preparation of nanocomposite membranes loaded with taxifolin liposome and its mechanism of wound healing in diabetic mice

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 241, P. 124537 - 124537

Published: April 20, 2023

Language: Английский

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Enhancing angiogenesis: Innovative drug delivery systems to facilitate diabetic wound healing

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116035 - 116035

Published: Dec. 19, 2023

Diabetic wounds (DW) constitute a substantial burden on global healthcare owing to their widespread occurrence as complication of diabetes. Angiogenesis, crucial process, plays pivotal role in tissue recovery by supplying essential oxygen and nutrients the injury site. Unfortunately, diabetes mellitus, various factors disrupt angiogenesis, hindering wound healing. While biomaterials designed enhance angiogenesis hold promise for treatment DWs, there is an urgent need more in-depth investigations fully unlock potential clinical management. In this review, we explore intricate mechanisms that are DW recovery. We introduce rational design angiogenesis-enhancing drug delivery systems (DDS) provide comprehensive summary discussion diverse facilitating Lastly, address emerging challenges prospects DDS healing, aiming offer understanding critical issue solutions.

Language: Английский

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Ultrasound targeted microbubble destruction-triggered nitric oxide release via nanoscale ultrasound contrast agent for sensitizing chemoimmunotherapy

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 30, 2023

Immunotherapy had demonstrated inspiring effects in tumor treatment, but only a minority of people could benefit owing to the hypoxic and immune-suppressed microenvironment (TME). Therefore, there was an urgent need for strategy that relieve hypoxia increase infiltration lymphocytes simultaneously. In this study, novel acidity-responsive nanoscale ultrasound contrast agent (L-Arg@PTX nanodroplets) constructed co-deliver paclitaxel (PTX) L-arginine (L-Arg) using homogenization/emulsification method. The L-Arg@PTX nanodroplets with uniform size about 300 nm high drug loading efficiency displayed good diagnostic imaging capability, improved aggregation achieved ultrasound-triggered release, which prevent premature leakage drugs thus improve biosafety. More critically, combination targeted microbubble destruction (UTMD) cellular reactive oxygen species (ROS), exerted oxidizing effect converted L-Arg into nitric oxide (NO), alleviating hypoxia, sensitizing chemotherapy increasing CD8 + cytotoxic T (CTLs) infiltration. Combined chemotherapeutic PTX-induced immunogenic cell death (ICD), promising enhance immunotherapy synergistically realize powerful treatment effect. Taken together, very hopeful vehicle integrated delivery, imaging, chemoimmunotherapy.

Language: Английский

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