The protective effects of medicinal plants against cigarette smoke: A comprehensive review

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156199 - 156199

Published: Oct. 30, 2024

Language: Английский

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An instant beverage rich in nutrients and secondary metabolites manufactured from stems and leaves of Panax notoginseng

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 7, 2022

Radix Notoginseng, one of the most famous Chinese traditional medicines, is dried root Panax notoginseng (Araliaceae). Stems and leaves P. (SLPN) are rich in secondary metabolites nutrients, authorized as a food resource, however, its utilization needs further research.A SLPN-instant beverage was manufactured from SLPN through optimization by response surface design with 21-fold 48.50% ethanol for 39 h, this extraction repeated twice; solution concentrated to 1/3 volume using vacuum rotatory evaporator at 45°C, then spray 110°C. Nutritional components including 14 amino acids, ten mineral elements, 15 vitamins were detected beverage; forty-three triterpenoid saponins, e.g., ginsenoside La, Rb3, notoginsenoside R1, two flavonoid glycosides, well dencichine identified UPLC-MS.The rate 37.89 ± 0.02%. The majority nutrients Gly (2.10 0.63 mg/g), His (1.23 0.07 α-VE (18.89 1.87 μg/g), β-VE (17.53 1.98 potassium (49.26 2.70 calcium (6.73 0.27 mg/g). total saponin 403.05 34.98 mg/g, Fd contents 227 2.02 mg/g. In addition, catechin γ-aminobutyric acid levels 24.57 0.21 mg/g 7.50 1.85 respectively. showed good antioxidant activities half maximal inhibitory concentration (IC50) scavenging hydroxyl (OH-) radicals, superoxide anion (O2-) 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS+) 0.1954, 0.2314, 0.4083, 0.3874 mg/mL, respectively.We optimized an analytical method depth analysis newly resource SLPN. Together, instant activity, metabolites, SLPN, which may improve

Language: Английский

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Exploring the pharmacological mechanisms of Biyan Qingdu Granula in the treatment after nasopharyngeal carcinoma radiotherapy based on UPLC/Q-TOF MS, network pharmacology and molecular docking

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2023, Volume and Issue: 239, P. 115830 - 115830

Published: Oct. 30, 2023

Language: Английский

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Ginseng and ginsenosides on cardiovascular and pulmonary diseases; Pharmacological potentials for the coronavirus (COVID-19)

Journal of Ginseng Research, Journal Year: 2023, Volume and Issue: 48(2), P. 113 - 121

Published: Nov. 2, 2023

Since its outbreak in late 2019, the Coronavirus disease 2019 (COVID-19) pandemic has profoundly caused global morbidity and deaths. The COVID-19 by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) major complications cardiovascular pulmonary system. increased rate of mortality is due to delayed detection certain biomarkers that are crucial development disease. Furthermore, proteins enzymes cellular signaling pathways play an important role replication SARS-CoV-2. Most cases mild moderate symptoms, however severe leads death. Detecting level such as C-reactive protein, cardiac troponin, creatine kinase, kinase-MB, procalcitonin Matrix metalloproteinases helps early severity Similarly, through downregulating Renin-angiotensin system, interleukin, Mitogen-activated protein kinases Phosphoinositide 3-kinases pathways, can be effectively controlled could prevented. Ginseng ginsenosides possess therapeutic potential complications, there several studies performed which they have suppressed these downregulated thereby inhibiting further spread Supplementation with ginseng or ginsenoside act on multiple reduce significantly alleviate damage. Therefore, this review summarizes extract controlling diseases COVID-19.

Language: Английский

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Exploring the boost of steaming with wine on Ligustri Lucidi Fructus in treating postmenopausal osteoporosis based on superior “multi-component structure” and iron/bone metabolism coregulation

Phytomedicine, Journal Year: 2023, Volume and Issue: 123, P. 155275 - 155275

Published: Dec. 12, 2023

Language: Английский

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Protective effect of Xixin–Ganjiang herb pair for warming the lungs to dissolve phlegm in chronic obstructive pulmonary disease rats based on integrated network pharmacology and metabolomics

Biomedical Chromatography, Journal Year: 2024, Volume and Issue: 38(6)

Published: March 6, 2024

Abstract Xixin–Ganjiang herb pair (XGHP) is a classic combination for warming the lungs to dissolve phlegm and often used treat variety of chronic lung diseases; it can syndrome cold obstruction lungs. First, ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) was examine composition XGHP, network pharmacology predict its potential core targets signaling pathways in current study. Second, rat model obstructive pulmonary disease (COPD) established assessing anti‐COPD activity metabolomics explore biomarkers metabolic pathways. Finally, sample validated using molecular docking Western blotting. The integration results identified 11 targets, 3 biomarkers, pathways, 2 blotting showed that XGHP effectively regulated expression proteins via multiple (downregulation toll‐like receptor 4 [ TLR4 ] upregulation serine/threonine‐protein kinase 1 p‐AKT1 nitric oxide synthase NOS3 ]). Molecular 10 potentially active components have good affinity with tumor necrosis factor‐alpha ( TNF‐α ), interleukin‐6 IL‐6 matrix metalloproteinase 9 MMP‐9 , . Our findings suggest may regulate glucolipid metabolism, improve energy supply, inhibit inflammatory responses ) PI3K‐Akt pathway HIF‐1 management COPD.

Language: Английский

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Polygala Tenuifolia Willd Water Extract Delays the Progression of Cigarette Smoke-Induced Copd in Mice by Inhibiting Pulmonary Inflammation and Remodeling Gut Microbiota Homeostasis

Published: Jan. 1, 2024

Language: Английский

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Therapeutic potential of Cordyceps sinensis targeting oxidative stress and inflammatory response in the treatment of COPD rats: insights from metabolomics analysis

Journal of Asian Natural Products Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Sept. 17, 2024

This study aimed to investigate the effects of wild

Language: Английский

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Fritillaria cirrhosa D. Don Alleviates Inflammatory Progression and Suppresses M1 Polarization of Macrophages in Chronic Obstructive Pulmonary Disease

International Archives of Allergy and Immunology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Sept. 16, 2024

Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive and largely irreversible disease. Current therapeutic approaches for COPD are limited in terms of slowing progression suppressing inflammation. Therefore, this study aimed to identify method alleviating inflammation COPD. Methods: A COPD-like mouse model was established treated with or without Fritillaria cirrhosa D. Don (hereinafter referred as Fritillaria). The expression levels inflammatory cytokines serum were detected by using enzyme-linked immunosorbent assay (ELISA). Additionally, lung tissue analyzed hematoxylin-eosin staining immunohistochemistry analysis, respectively. MLE-12 cells exposed cigarette smoke extract (CSE) Fritillaria. MTT conducted assess cell viability. activation NF-κB p65 determined Western blotting (WB). Finally, flow cytometry applied analyze the M1 macrophage percentage. Results: results displayed that downregulated IL-1β, IL-6, IL-8, TNF-α cells. alleviated response mice. viability considerably decreased when CSE, which could be restored adding reduced pro-inflammatory factor inhibited polarization macrophages, thereby mitigating response. Conclusion: In conclusion, exhibits beneficial effects infection-related both vitro experiments.

Language: Английский

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Oleanolic acid 28-O-β-D-glucopyranoside: A novel therapeutic agent against ulcerative colitis via anti-inflammatory, barrier-preservation, and gut microbiota-modulation

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117534 - 117534

Published: Oct. 13, 2024

Language: Английский

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