Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114500 - 114500
Published: Jan. 6, 2025
Language: Английский
Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123472 - 123472
Published: Feb. 1, 2025
Language: Английский
Citations
1
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3471 - 3491
Published: March 1, 2025
Cancer stands as a formidable malady profoundly impacting human health. Throughout history, plant-based therapies have remained pivotal in the arsenal against cancer, evolving alongside epochs. Presently, challenges such arduous extraction of active components and potential safety concerns impede progression anticancer therapies. The isolation plant-derived vesicle-like nanoparticles (PDVLNs), kind lipid bilayer capsules isolated from plants, has brought therapy into novel realm led to decades research on PDVLNs. Accumulating evidence indicates that PDVLNs can deliver substances cells regulate cellular functions. Regulating immunity, inducing cell cycle arrest, promoting apoptosis cancer are most commonly reported mechanisms tumor suppression. Low immunogenicity lack tumorigenicity make good platform for drug delivery. molecules within all source so selection plants is crucial. In recent years, there been clear trend changed vegetables or fruits medicinal plants. This review highlights identify candidate More importantly, current PDVLN-based applications delivery systematically discussed.
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: March 16, 2024
Abstract Background Rice bran a by-product of the rice milling process is currently underutilized. Recent studies have shown that plant-derived nanoparticles (pdNPs) can be mass-produced at low cost and exhibit biological therapeutic activities. contains various anti-cancer compounds, including γ-oryzanol γ-tocotrienol, bran-derived (rbNPs) employed as novel agents for cancer treatment. Results Koshihikari was suspended in water, suspension centrifuged filtered through 0.45-µm-pore size syringe filter. The filtrate ultracentrifuged, precipitates were to obtain rbNPs. rbNPs negatively charged exosome-like with an average diameter approximately 130 nm. exhibited cytotoxic activities against cells but not normal cells. activity murine colon adenocarcinoma colon26 significantly greater than DOXIL ® or other pdNPs. induced cell cycle arrest apoptosis, reduced expression proliferative proteins, β-catenin cyclin D1. Intraperitoneal injections into mice bearing peritoneal dissemination suppressed tumor growth no significant adverse effects. Conclusion These results indicated are promising nanoparticles, hold potential applications, expected play vital role
Language: Английский
Citations
8
Processes, Journal Year: 2024, Volume and Issue: 12(12), P. 2938 - 2938
Published: Dec. 23, 2024
Plant-derived extracellular vesicles (PDEVs) are lipid bilayer nanoparticles, naturally produced by plant cells, with sizes ranging from 50 to 500 nm. Recent studies have highlighted their great potential in the biotechnological and medical fields, due natural origin, high biocompatibility intrinsic therapeutic properties. PDEVs contain a complex biological cargo of proteins, lipids, nucleic acids secondary metabolites, including antioxidants anti-inflammatory molecules, making them ideal for biomedical applications such as drug delivery. These play key role intercellular communication gene regulation, proving be particularly promising personalized medicine. ability improve stability bioavailability, optimizing targeted release minimizing side effects. Despite some challenges, compositional variability need standardized protocols, at gunsight innovative research aimed improving loading capacity specificity. This review aims provide comprehensive overview PDEVs, exploring structure, isolation methods, functional characteristics, applications, highlighting advantages over synthetic nanoparticles animal-derived vesicles, leading an sustainable solution development new approaches.
Language: Английский
Citations
7
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: Nov. 24, 2023
Abstract Tissue damage and aging lead to dysfunction, disfigurement, trauma, posing significant global challenges. Creating a regenerative microenvironment resist external stimuli induce stem cell differentiation is essential. Plant-derived nanovesicles (PDNVs) are naturally bioactive lipid bilayer that contain proteins, lipids, ribonucleic acid, metabolites. They have shown potential in promoting growth, migration, into various types of tissues. With immunomodulatory, microbiota regulatory, antioxidant, anti-aging bioactivities, PDNVs valuable resisting facilitating tissue repair. The unique structure provides an optimal platform for drug encapsulation, surface modifications enhance their stability specificity. Moreover, by employing synergistic administration strategies, can maximize therapeutic potential. This review summarized the progress prospects as tools, provided insights selection repair activities based on existing studies, considered key challenge clinical application, anticipated continued prominent role field biomedicine. Graphical
Language: Английский
Citations
17
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 6847 - 6868
Published: Nov. 1, 2023
Abstract: Lipid-structured vesicles have been applied for drug delivery system over 50 years. Based on their origin, lipid-structured are divided into two main categories, namely synthetic lipid (SLNVEs) and of mammalian origin (MDVEs). Although SLNVEs can stably transport anti-cancer drugs, biocompatibility is poor degradation exogenous substances a potential risk. Unlike SLNVEs, MDVEs excellent but limited by lack stability risk contamination dangerous pathogens from donor cells. Since the first discovery plant-derived (PDVEs) in carrot cell supernatants 1967, emerging evidence has shown that PDVEs integrate advantages both MDVEs. Notably, 55 years dedicated research indicated an ideal candidate vesicle preparation, transport, disease treatment. The current review systematically focuses role cancer therapy particular compares properties with those conventional vesicles, summarizes preparation methods quality control PDVEs, discusses application delivering drugs underlying molecular mechanisms therapy. Finally, challenges future perspectives development novel therapeutic strategies against discussed. Keywords: therapy, delivery, liposome nanoparticles, mammalian-derived exosomes
Language: Английский
Citations
16
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7559 - 7559
Published: July 10, 2024
This systematic review offers a comprehensive analysis of plant-derived extracellular vesicles (PDEVs) as emerging drug delivery systems, focusing on original research articles published between 2016 and 2024 that exclusively examine the use PDEVs for delivery. After rigorous search across multiple databases, 20 relevant studies out 805 initial results were selected analysis. systematically summarizes critical data PDEV components, isolation methods, drug-loading techniques. It highlights potential to significantly enhance safety efficacy, reduce dosage toxicity, align development with sustainable environmentally friendly biotechnological processes. also emphasizes advantages over mammalian-derived vesicles, such cost-effectiveness, higher yield, reduced immunogenicity. Additionally, it explores synergistic encapsulated drugs bioactive compounds naturally present in PDEVs. study acknowledges challenges standardizing formulation methods clinical use. Overall, this provides valuable insights into current state future directions PDEV-based highlighting their promising role advancing pharmaceutical development.
Language: Английский
Citations
6
MedComm, Journal Year: 2024, Volume and Issue: 5(10)
Published: Sept. 17, 2024
Liver cirrhosis is the end-stage of chronic liver disease, characterized by inflammation, necrosis, advanced fibrosis, and regenerative nodule formation. Long-term inflammation can cause continuous damage to tissues hepatocytes, along with increased vascular tone portal hypertension. Among them, fibrosis necessary stage essential feature cirrhosis, effective antifibrosis strategies are commonly considered key treating cirrhosis. Although different therapeutic aimed at reversing or preventing have been developed, effects not be more satisfactory. In this review, we discussed abnormal changes in microenvironment that contribute progression highlighted importance recent strategies, including lifestyle improvement, small molecular agents, traditional Chinese medicine, stem cells, extracellular vesicles, gut remediation, regulate Meanwhile, for nanoparticles discussed, as their possible underlying broad application prospects ameliorating Finally, also reviewed major challenges opportunities nanomedicine‒biological environment interactions. We hope review will provide insights into pathogenesis mechanisms thus facilitating new methods, drug discovery, better treatment
Language: Английский
Citations
6
Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155750 - 155750
Published: May 19, 2024
Language: Английский
Citations
5
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(4), P. 188905 - 188905
Published: May 8, 2023
Language: Английский
Citations
13