Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12293 - 12293

Published: July 31, 2023

The roots and rhizomes of Rhodiola rosea L. (Crassulaceae), which is widely growing in Northern Europe, North America, Siberia, have been used since ancient times to alleviate stress, fatigue, mental physical disorders. Phenolic compounds: phenylpropanoids rosavin, rosarin, rosin, tyrosol glucoside salidroside, tyrosol, are responsible for the biological action R. rosea, exerting antioxidant, immunomodulatory, anti-aging, anti-fatigue activities. extract formulations as alternative remedies enhance cognitive functions protect central nervous system heart during stress. Recent studies indicate that may be treat diabetes, cancer, a variety cardiovascular neurological disorders such Alzheimer's Parkinson's diseases. This paper reviews beneficial effects its key active components, their possible use treatment chronic represents an excellent natural remedy address situations involving decreased performance, fatigue sense weakness, particularly context Given significance mitochondria cellular energy metabolism vulnerability reactive oxygen species, future research should prioritize investigating potential main bioactive phenolic compounds on mitochondria, thus targeting supply countering oxidative stress-related effects.

Language: Английский

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Pharmacological functions of salidroside in renal diseases: facts and perspectives

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Rhodiola rosea is a valuable functional medicinal plant widely utilized in China and other Asian countries for its anti-fatigue, anti-aging, altitude sickness prevention properties. Salidroside, most active constituent derived from , exhibits potent antioxidative, hypoxia-resistant, anti-inflammatory, anticancer, anti-aging effects that have garnered significant attention. The appreciation of the pharmacological role salidroside has burgeoned over last decade, making it beneficial option treatment multiple diseases, including atherosclerosis, Alzheimer’s disease, Parkinson’s cardiovascular more. With renoprotective effects, parallel with inhibition oxidative stress inflammation, holds promise as potential therapeutic agent kidney damage. This article provides an overview microinflammatory state disease discuss current strategies, particular focus on highlighting recent advancements utilizing renal disease. mechanisms action are primarily associated regulation gene protein expression glomerular endothelial cells, podocytes, tubule mesangial cells cell carcinoma cell, TNF-α, TGF-β, IL-1β, IL-17A, IL-6, MCP-1, Bcl-2, VEGF, ECM protein, caspase-3, HIF-1α, BIM, well modulation AMPK/SIRT1, Nrf2/HO-1, Sirt1/PGC-1α, ROS/Src/Cav-1, Akt/GSK-3β, TXNIP-NLRP3, ERK1/2, TGF-β1/Smad2/3, PI3K/Akt, Wnt1/Wnt3a β-catenin, TLR4/NF-κB, MAPK, JAK2/STAT3, SIRT1/Nrf2 pathways. To best our knowledge, this review first to comprehensively cover protective diverse suggests great be developed drug metabolic syndrome, cerebrovascular diseases complications.

Language: Английский

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Research Progress in the Molecular Mechanism of NLRP3 Inflammasome in Alzheimer’s Disease and Regulation by Natural Plant Products

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

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Decoding Ischemic Stroke: Perspectives on the Endoplasmic Reticulum, Mitochondria, and Their Crosstalk

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103622 - 103622

Published: March 1, 2025

Stroke is known for its high disability and mortality rates. Ischemic stroke (IS), the most prevalent form, imposes a considerable burden on affected individuals. Nevertheless, existing treatment modalities are hindered by limitations, including narrow therapeutic windows, substantial adverse effects, suboptimal neurological recovery. Clarifying pathological mechanism of IS prerequisite developing new strategies. In this context, functional disruption mitochondria, endoplasmic reticulum (ER), crosstalk mechanisms between them have garnered increasing attention their contributory roles in progression IS. Therefore, review provides comprehensive summary current pathomechanisms associated with involvement ER mitochondria IS, emphasising Ca2+ destabilization homeostasis, stress, oxidative disordered mitochondrial quality control, transfer. Additionally, article highlights interaction as well mitochondrial-ER contacts (MERCs) that structurally connect ER, aiming to provide ideas references research

Language: Английский

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Targeting ferroptosis as a promising therapeutic strategy to treat cardiomyopathy

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: April 13, 2023

Cardiomyopathies are a clinically heterogeneous group of cardiac diseases characterized by heart muscle damage, resulting in myocardium disorders, diminished function, failure, and even sudden death. The molecular mechanisms underlying the damage to cardiomyocytes remain unclear. Emerging studies have demonstrated that ferroptosis, an iron-dependent non-apoptotic regulated form cell death iron dyshomeostasis lipid peroxidation, contributes development ischemic cardiomyopathy, diabetic doxorubicin-induced septic cardiomyopathy. Numerous compounds exerted potential therapeutic effects on cardiomyopathies inhibiting ferroptosis. In this review, we summarize core mechanism which ferroptosis leads these cardiomyopathies. We emphasize emerging types can inhibit delineate their beneficial treating This review suggests pharmacologically may be strategy for cardiomyopathy treatment.

Language: Английский

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Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102063 - 102063

Published: Sept. 9, 2023

Language: Английский

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Ferroptosis: A novel therapeutic target of natural products against doxorubicin-induced cardiotoxicity

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117217 - 117217

Published: July 29, 2024

Doxorubicin (DOX), a commonly used chemotherapy drug, is hindered due to its tendency induce cardiotoxicity (DIC). Ferroptosis, novel mode of programmed cell death, has received substantial attention for involvement in DIC. Recently, natural product-derived ferroptosis regulator emerged as potential strategy treating In this review, comprehensive search was conducted across PubMed, Web Science, Google Scholar, and ScienceDirect databases gather relevant articles on the use products DIC relation ferroptosis. The available papers were carefully reviewed summarize therapeutic effects underlying mechanisms modulating treatment. It found that plays an important role pathogenesis, with dysregulated expression ferroptosis-related proteins strongly implicated condition. Natural products, such flavonoids, polyphenols, terpenoids, quinones can act GPX4 activators, Nrf2 agonists, lipid peroxidation inhibitors, thereby enhancing viability, attenuating myocardial fibrosis, improving cardiac function, suppressing both vitro vivo models This review demonstrates strong correlation between DOX-induced key proteins, GPX4, Keap1, Nrf2, AMPK, HMOX1. are likely exert against by activity these proteins.

Language: Английский

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Hairy Root Cultures as a Source of Phenolic Antioxidants: Simple Phenolics, Phenolic Acids, Phenylethanoids, and Hydroxycinnamates

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 6920 - 6920

Published: April 7, 2023

Plant-derived antioxidants are intrinsic components of human diet and factors implicated in tolerance mechanisms against environmental stresses both plants humans. They being used as food preservatives additives or ingredients cosmetics. For nearly forty years, Rhizobium rhizogenes-transformed roots (hairy roots) have been studied respect to their usability producers plant specialized metabolites different, primarily medical applications. Moreover, the hairy root cultures proven value a tool crop improvement secondary metabolism investigations. Though cultivated remain major source polyphenolics economic importance, decline biodiversity caused by climate changes overexploitation natural resources may increase interest productive renewable biologically active compounds. The present review examines efficient simple phenolics, phenylethanoids, hydroxycinnamates origin summarizes efforts maximize product yield. Attempts use rhizogenes-mediated genetic transformation for inducing enhanced production phenolics/polyphenolics also mentioned.

Language: Английский

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Phytochemical profiling and neuroprotective activity of Callistemon subulatus leaves against cyclophosphamide-induced chemobrain

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115596 - 115596

Published: Oct. 3, 2023

Cyclophosphamide (CPA) is a chemotherapeutic drug used for various types of cancers. However, patients receiving CPA long periods suffer cognitive impairment associated with difficulties in learning, decreased concentration, and impaired memory. Chemotherapy-induced impairment, known as chemobrain, has been attributed to enhanced oxidative stress inflammatory response. The current study aimed identify the phytoconstituents Callistemon subulatus extract (CSE) using HPLC-ESI/MS-MS analysis evaluate its neuroprotective activity against CPA-induced chemobrain rats. Fourteen compounds were identified following HPLC including, five phlorglucinols, four flavonol glycosides, triterpene, phenolic acid. Forty rats divided into groups treated ten days follows; group I (control group), II received (200 mg/kg, i.p.) on 7th day, III IV CSE 400 mg/kg respectively, orally) V only (400 days. administration effectively ameliorated deleterious effects spatial short-term memories, evidenced by behavioral tests, Y-maze passive avoidance. Such findings further confirmed histological examination. In addition, counteracted effect hippocampal acetylcholinesterase (AChE) enhancing level acetylcholine. Owing antioxidant properties, it hindered redox imbalance, which represented catalase reduced glutathione levels, well lipid peroxidation. Therefore, may be promising natural candidate protection cancer patients.

Language: Английский

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The food and medicine homologous Chinese Medicine from Leguminosae species: A comprehensive review on bioactive constituents with neuroprotective effects on nervous system

Food & medicine homology., Journal Year: 2024, Volume and Issue: 2(2), P. 9420033 - 9420033

Published: Sept. 4, 2024

Language: Английский

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