Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review

Molecules, Journal Year: 2024, Volume and Issue: 29(4), P. 866 - 866

Published: Feb. 15, 2024

Introduction: Adaptogens are a group of plants that exhibit complex, nonspecific effects on the human body, increasing its ability to adapt, develop resilience, and survive in stress conditions. They found many traditional medicinal systems play key role restoring body’s strength stamina. Research recent years has attempted elucidate mechanisms behind their pharmacological effects, but it appears these difficult define precisely involve multiple molecular pathways. Neuroinflammation: In years, chronic inflammation been recognized as one common features central nervous system disorders (dementia other neurodegenerative diseases, depression, anxiety, ischemic stroke, infections). Because specific nature brain, this process is called neuroinflammation, suppression can result an improvement patients’ condition may promote recovery. anti-inflammatory agents: As discovered, adaptogens display which suggests application be broader than previously thought. regulate gene expression anti- proinflammatory cytokines (prostaglandins, leukotriens) modulate signaling pathways (e.g., NF-κB). Aim: This mini-review aims present anti-neuroinflammatory potential most important classified adaptogens: Schisandra chinensis, Eleutherococcus senticosus, Rhodiola rosea Withania somnifera.

Language: Английский

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The Role of Rosavin in the Pathophysiology of Bone Metabolism

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2117 - 2117

Published: Feb. 9, 2024

Rosavin, a phenylpropanoid in Rhodiola rosea's rhizome, and an adaptogen, is known for enhancing the body's response to environmental stress. It significantly affects cellular metabolism health many diseases, particularly influencing bone tissue metabolism. In vitro, rosavin inhibits osteoclastogenesis, disrupts F-actin ring formation, reduces expression of osteoclastogenesis-related genes such as cathepsin K, calcitonin receptor (CTR), tumor necrosis factor receptor-associated 6 (TRAF6), tartrate-resistant acid phosphatase (TRAP), matrix metallopeptidase 9 (MMP-9). also impedes nuclear activated T-cell cytoplasmic 1 (NFATc1), c-Fos, kappa-light-chain-enhancer B cells (NF-κB), mitogen-activated protein kinase (MAPK) signaling pathways blocks phosphorylation processes crucial resorption. Moreover, promotes osteogenesis osteoblast differentiation increases mouse runt-related transcription 2 (Runx2) osteocalcin (OCN) expression. vivo studies show its effectiveness mineral density (BMD) postmenopausal osteoporosis (PMOP) mice, restraining osteoclast maturation, increasing active percentage tissue. modulates mRNA expressions by eukaryotic translation elongation (EEF2) decreasing histone deacetylase (HDAC1), thereby activating osteoprotective epigenetic mechanisms, alters serum markers, including cross-linked C-telopeptide type I collagen (CTX-1), 5b (TRACP5b), activator κ ligand (RANKL), macrophage-colony-stimulating (M-CSF), TRAP, while alkaline (ALP) OCN. Additionally, when combined with zinc probiotics, it pro-osteoporotic 3 (MMP-3), interleukin (IL-6), α (TNF-α), enhances anti-osteoporotic 10 (IL-10) inhibitor metalloproteinase (TIMP3) expressions. This paper aims systematically review rosavin's impact on metabolism, exploring potential prevention treatment, suggesting future research directions.

Language: Английский

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Investigating beta-endorphins: Ways to boost health, conventional and future detection methods

Process Biochemistry, Journal Year: 2024, Volume and Issue: 141, P. 102 - 111

Published: March 16, 2024

Language: Английский

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Rosavin: Research Advances in Extraction and Synthesis, Pharmacological Activities and Therapeutic Effects on Diseases of the Characteristic Active Ingredients of Rhodiola rosea L.

Molecules, Journal Year: 2023, Volume and Issue: 28(21), P. 7412 - 7412

Published: Nov. 3, 2023

Rhodiola rosea L. (RRL) is a popular plant in traditional medicine, and Rosavin, characteristic ingredient of RRL, considered one the most important active ingredients it. In recent years, with deepening research on its pharmacological actions, clinical application value demand for Rosavin have been steadily increasing. Various routes extraction all-chemical or biological synthesis gradually developed large-scale production broad Rosavin. Pharmacological studies demonstrated that has variety activities, including antioxidant, lipid-lowering, analgesic, antiradiation, antitumor immunomodulation effects. showed significant therapeutic effects range chronic diseases, neurological, digestive, respiratory bone-related disorders during vitro vivo experiments, demonstrating great potential as drug diseases. This paper gives comprehensive insightful overview focusing synthesis, progress disease-treatment formulation studies, providing reference preparation, further applications future.

Language: Английский

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Scalable and Practical Approach of Phenol Formation from Hydroxylation of Arylboronic Acids under Metal-, Photocatalyst-, and Light-Free Conditions

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Phenols are of particular importance owing to their widespread application in various fields, including life sciences and synthetic chemistry. However, the typical strategies phenol either rely on metal- or photo-catalysts involve stringent conditions such as high temperature, strong oxidants, acidic basic environments. Herein, we present a remarkably simple, ecofriendly, photocatalyst-free synthesis phenols. In contrast conventional methods, which relies expensive catalysts hazardous reagents, current diacetoxyiodobenzene-mediated hydroxylation arylboronic acid protocol offers significant improvement terms costs, operational simplicity, toxicity, sustainability. The reaction does not require temperature light activation shows good functional group compatibility conversion efficiency (55–96%). Moreover, these mild also useful for gram-scale without compromising yield.

Language: Английский

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Synthesis and Health Effects of Phenolic Compounds: A Focus on Tyrosol, Hydroxytyrosol, and 3,4-Dihydroxyacetophenone

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 476 - 476

Published: April 16, 2025

Tyrosol (Tyr), hydroxytyrosol (TH), and 3,4-Dihydroxyacetophenone (3,4-DHAP) are three phenolic compounds naturally present in plants that have attracted considerable research attention due to their potent antioxidant, anti-inflammatory, anticancer, cardiovascular protective properties. In recent years, mounting evidence has indicated these hold broad potential both disease prevention treatment. This paper reviews the chemical structures synthetic methods of Tyr, HT, 3,4-DHAP, as well multifaceted effects on human health, particularly roles mechanisms antioxidation, anti-inflammation, protection, neuroprotection, anticancer activity. addition, this explores future prospects current challenges associated with application—such low bioavailability long-term safety concerns—and proposes directions for further investigation.

Language: Английский

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Salidroside alleviates Aβ1-42-induced ferroptosis in human neuroblastoma cells by AKT/GSK-3β activation via inhibiting VDAC1

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100802 - 100802

Published: May 1, 2025

Language: Английский

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High-level production of Rhodiola rosea characteristic component rosavin from D-glucose and L-arabinose in engineered Escherichia coli

Metabolic Engineering, Journal Year: 2024, Volume and Issue: 82, P. 274 - 285

Published: Feb. 28, 2024

Language: Английский

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Therapeutic Promises of Bioactive Rosavin: A Comprehensive Review with Mechanistic Insight

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(7)

Published: May 16, 2024

Rosavin is an alkylbenzene diglycoside primarily found in Rhodiola rosea (L.), demonstrating various pharmacological properties a number of preclinical test systems. This study focuses on evaluating the effects rosavin and underlying molecular mechanisms based different non-clinical investigations. The findings revealed that has anti-microbial, antioxidant, protective effects, including neuroprotective against neurodegenerative ailments such as mild cognitive disorders, neuropathic pain, depression, stress, well gastroprotective, osteoprotective, pulmoprotective, hepatoprotective activities. effect due to its capability diminish inflammation oxidative stress. compound also manifested anticancer cancer via exerting cytotoxicity, apoptotic cell death, arresting phases (G

Language: Английский

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The Role of Rosavin in the Pathophysiology of Bone Metabolism

Published: Jan. 4, 2024

Rosavin, a phenylpropanoid in Rhodiola rosea's rhizome, an adaptogen, is known for enhancing the body's response to environmental stress. It significantly affects cellular metabolism health and many diseases, particularly influencing bone tissue metabolism. In vitro, rosavin inhibits osteoclastogenesis, disrupts F-actin rings formation, lowers osteoclastogenesis-related gene expression (cathepsin K, CTR, TRAF6, TRAP, MMP-9). also impedes NFATc1, c-Fos, NF-κB, MAPK signaling pathways, blocks phosphorylation processes crucial resorption. Moreover, promotes osteogenesis, osteoblast differentiation increases Runx2 OCN expression. vivo studies show its effectiveness BMD PMOP mice, re-straining osteoclast maturation, increasing active percentage tissue. modulates mRNA expressions (increasing EEF2 decreasing HDAC1, thereby activating os-teoprotective epigenetic mechanisms) alters various serum markers, including decrease of CTX-1, TRAcp5b, RANKL, M-CSF, increase ALP OCN. Additionally, when combined with zinc probiotics, it reduces pro-osteoporotic MMP-3, IL-6, TNF-α, en-hances anti-osteoporotic IL-10 TIMP3 expressions. This paper aims systematically review rosavin's impact on metabolism, exploring potential osteoporosis prevention treatment, suggesting future research directions.

Language: Английский

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