Food Bioscience, Journal Year: 2023, Volume and Issue: 57, P. 103454 - 103454
Published: Dec. 10, 2023
Language: Английский
The American Journal of Chinese Medicine, Journal Year: 2024, Volume and Issue: 52(03), P. 667 - 716
Published: Jan. 1, 2024
Licorice (Glycyrrhiza) is a medicinal and food homologue of perennial plants derived from the dried roots rhizomes genus Glycyrrhiza in legume family. In recent years, comprehensive utilization licorice resources has attracted people’s attention. It widely utilized to treat diseases, health products, production, other industrial applications. Furthermore, numerous bioactive components are found using advanced extraction processes, which mainly include polyphenols (flavonoids, dihydrostilbenes, benzofurans, coumarin), triterpenoids, polysaccharides, alkaloids, volatile oils, all have been reported possess variety pharmacological characteristics, including anti-oxidant, anti-inflammatory, antibacterial, antiviral, anticancer, neuroprotective, antidepressive, antidiabetic, antiparasitic, antisex hormone, skin effects, anticariogenic, antitussive, expectorant activities. Thereby, these compounds promote development novel more effective licorice-derived products. This paper reviews progress research on techniques, chemical composition, bioactivities, applications provide reference for further application different areas.
Language: Английский
Citations
15
Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155814 - 155814
Published: June 12, 2024
Alcohol-associated liver disease (ALD) is a prevalent ailment. It has escalated into significant public health issue, imposing substantial burdens on medical, economic, and social domains. Currently, oxidative stress, inflammation, apoptosis are recognized as crucial culprits in improving ALD. Consequently, mitigating these issues emerged promising avenue for enhancing Hydroxysafflor yellow A (HSYA) the main ingredient safflower, showing excellent antioxidative anti-inflammatory, anti-apoptosis traits. However, there limited investigations mechanisms by which HSYA ameliorates ALD PURPOSE: We investigated whether HSYA, constituent of Asteraceae exerts antioxidant stress attenuates inflammation anti-apoptotic effects through PI3K/Akt STAT3/NF-κB pathways, thereby ameliorating METHODS: established two experimental models: an ethanol-induced damage mouse model vivo HepG2 cell alcohol injury vitro RESULTS: The results demonstrated that effectively ameliorated tissue damage, reduced levels ALT, AST, LDL-C, TG, TC, MDA, enhanced HDL-C levels, SOD GSH activities, ROS accumulation cells, activated Nrf2 pathway, transcription factor involved defense. By regulating exhibits notable effects, impeding ALD's advancement. To further confirm regulatory effect downstream signaling PI3K activator 740 Y-P was used found to reverse downregulation CONCLUSION: This study supports effectiveness reducing indicating its potential medicinal value.
Language: Английский
Citations
9
Journal of Extracellular Vesicles, Journal Year: 2024, Volume and Issue: 13(4)
Published: April 1, 2024
Abstract Heterotopic ossification (HO) comprises the abnormal formation of ectopic bone in extraskeletal soft tissue. The factors that initiate HO remain elusive. Herein, we found calcified apoptotic vesicles (apoVs) led to increased calcification and stiffness tendon extracellular matrix (ECM), which initiated M2 macrophage polarization progression. Specifically, single‐cell transcriptome analyses different stages revealed apoVs were primarily secreted by a PROCR + fibroblast population. In addition, enriched calcium annexin channels, absorbed collagen I via electrostatic interaction, aggregated produce calcifying nodules ECM, leading stiffening. More importantly, apoV‐releasing inhibition or deletion both successfully reversed development. Thus, are first identify from fibroblasts as initiating factor HO, might serve therapeutic target for inhibiting pathological calcification.
Language: Английский
Citations
6
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116006 - 116006
Published: Dec. 12, 2023
Rheumatoid arthritis (RA) is a chronic inflammatory condition known for its irreversible destructive impact on the joints. Chondrocytes play pivotal role in production and maintenance of cartilage matrix. However, presence cytokines can hinder chondrocyte proliferation promote apoptosis. Isoliquiritigenin (ISL), flavonoid, potentially exerts protective effects against various diseases. specific regulating nuclear factor E2-associated 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway chondrocytes RA remains unclear. To investigate this, this study used human Sprague-Dawley rats to construct vitro vivo models, respectively. The findings reveal that markedly induced oxidative stress, activation matrix metalloproteinases, apoptosis both vivo. Notably, ISL treatment significantly mitigated these effects. Moreover, Nrf2 or HO-1 inhibitors reversed ISL, attenuated expression Nrf2/HO-1 peroxisome proliferator-activated receptor gamma-coactivator-1α, promoted This finding indicates primarily targets chondrocytes. led improved behavior scores, reduced paw thickness, joint damage as well ameliorated stress skeletal muscles an rat model. In conclusion, highlights demonstrates potential option RA.
Language: Английский
Citations
13
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 24, 2024
The liver is the largest, important organ and site for essential biochemical reactions in human body. It has function to detoxify toxic substances synthesize useful biomolecules. Liver diseases related complications represent a significant source of morbidity mortality worldwide, creating substantial economic burden. Oxidative stress, excessive inflammation, dysregulated energy metabolism significantly contributed diseases. Therefore, discovery novel therapeutic drugs treatment are urgently required. For centuries, flavonoids their preparations which have beneficial health effects chronic been used treat various illnesses. Flavonoids mainly include flavones, isoflavones, flavanols, dihydroflavones, dihydroflavonols, anthocyanins chalcones. primary objective this review assess efficacy safety flavonoids, from clinical point view considering clinically relevant end-points. We summarized recent progress research hepatoprotective molecular mechanisms different bioactive ingredients also outlined networks underlying signaling pathways. Further pharmacology toxicology will contribute development natural products derivatives as medicines with alluring prospect application.
Language: Английский
Citations
5
Aquaculture, Journal Year: 2024, Volume and Issue: 589, P. 740945 - 740945
Published: April 9, 2024
Language: Английский
Citations
4
Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155932 - 155932
Published: Aug. 8, 2024
Language: Английский
Citations
4
Epigenetics, Journal Year: 2025, Volume and Issue: 20(1)
Published: Feb. 7, 2025
Although N6-methyladenosine (m6A) may be related to the pathogenesis of fibrotic process, mechanism m6A modification in aging-related idiopathic pulmonary fibrosis (IPF) remains unclear. Three-milliliter venous blood was collected from IPF patients and healthy controls. MeRIP-seq RNA-seq were utilized investigate differential modification. The expressions identified regulator target gene validated using MeRIP-qPCR real-time PCR. Moreover, we established an animal model a senescent A549 cells explore associated molecular mechanism. Our study provided panorama methylation IPF. Increased peaks (3756) decreased (4712) observed group. association analysis showed that 749 DEGs affected by Among regulators, expression METTL14 level our interested DDIT4 significantly, but mRNA higher This further verified bleomycin-induced fibrosis. At cellular level, it confirmed might participate senescence alveolar epithelial cells. downregulation inhibit decay reducing mRNA, leading high protein. alterations discovered as potential intervention for epigenetic These results pave way future investigations regarding modifications
Language: Английский
Citations
0
Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Muscle atrophy is a pathological condition characterized by the excessive degradation of muscle proteins, leading to impaired physical performance. Isoliquiritigenin (ISL) promising extract known for its medical effects; however, impact on remains unclear. We investigated effects ISL both in vitro and vivo. The results showed that 5-µM exhibited no significant cytotoxicity C2C12 cells, as reflected cell count kit-8 5-ethynyl-2'-deoxyuridine (EdU) tests. increased diameter myotubes downregulated forkhead box O muscle-specific RING finger protein 1 (MuRF-1), Atrogin-1 induced Dexamethasone (Dex). could also enhance phosphorylation Akt, mammalian target rapamycin (mTOR), eIF4E-binding 1, p70 S6 kinase myotubes. In animal experiments, mass, improved cross-sectional area muscles, inhibited expression MuRF-1 tissues. For performance, enhanced grip strength running endurance. ameliorated Dex-induced vivo, associated with decreased via Akt/mTOR signaling pathway. This suggested be used natural drug atrophy.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 27, 2025
Alcoholic liver fibrosis (ALF) developed from long-term excessive alcohol consumption, which causes inflammatory reactions, lipid accumulation and cirrhosis. An imbalance in gut microbiota is a crucial driving factor for through the gut-liver axis. This study aimed to explore effect of physcion on ALF associated with HMGB1/NLRP3 pathways microbiota. C57BL/6 mice were used establish animal model ALF, LX-2 cells alcohol-activated cell model, intestinal contents collected analyzed by 16S rRNA sequencing. Physcion effectively ameliorated ALF-induced inflammation, collagen deposition, SirT1, AMPK phosphorylation SREBP1 expression. Moreover, pyroptosis-related proteins (Caspase-1, IL-1β, GSDMD) significantly reduced after treatment. Interestingly, diversity bacteria abundance treatment was higher, while harmful lower than that mice. Importantly, it found inhibit both vivo vitro , suppress extracellular matrix inhibiting Collagen-I α-SMA finally reverse hepatic stellate activation. Continuous administration HMGB1 NLRP3 inhibitors showed hepato-protection model. siRNA-mediated knock-down impaired physcion-mediated protection. Regulation pathway recovered injury further contributed physcion’s beneficial effects. Taken together, results reveal diminishes inflammasome/pyroptosis this diminishment hepato-protective against ALF.
Language: Английский
Citations
0