The Networked Interaction between Probiotics and Intestine in Health and Disease: A Promising Success Story

Microorganisms, Journal Year: 2024, Volume and Issue: 12(1), P. 194 - 194

Published: Jan. 18, 2024

Probiotics are known to promote human health either precautionary in healthy individuals or therapeutically patients suffering from certain ailments. Although this knowledge was empirical past tomes, modern science has already verified it and expanded new limits. These microorganisms can be found nature various foods such as dairy products supplements formulated for clinical preventive use. The current review examines the different mechanisms of action probiotic strains how they interact with organism host. Emphasis is put on therapeutic use these beneficial conditions gastrointestinal tract. Diseases tract particularly any malfunction inflammation intestines seriously compromise whole organism. interaction between host’s microbiota alleviate signs symptoms while some cases, due course, intervene underlying pathology. Various safety issues probiotics also discussed.

Language: Английский

---

The role and mechanism of action of microbiota-derived short-chain fatty acids in neutrophils: From the activation to becoming potential biomarkers

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 169, P. 115821 - 115821

Published: Nov. 10, 2023

Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, have emerged critical mediators in the communication between human microbiota its host. As first responder to inflammatory site, neutrophils play an important role protecting host against bacterial infections. Recent investigations revealed that SCFAs generated from influence various neutrophil activities, including activation, migration, generation of processes. also been demonstrated exhibit potential therapeutic benefits a variety disorders related dysfunction, bowel disease, viral infectious disorders, cancer. This study aims examine molecular processes behind complicated link neutrophils, well their on neutrophil-driven disorders. In addition, we will provide in-depth review current research diagnostic value possible biomarkers for neutrophil-related diseases.

Language: Английский

---

Dynamics of the Microbiota and Its Relationship with Post-COVID-19 Syndrome

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14822 - 14822

Published: Oct. 1, 2023

Coronavirus disease (COVID-19) is an infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can be asymptomatic or present with multiple organ dysfunction. Many infected individuals have chronic alterations associated neuropsychiatric, endocrine, gastrointestinal, and musculoskeletal symptoms, even several months after onset, developing long-COVID post-acute COVID-19 (PACS). Microbiota dysbiosis contributes to the onset progression of many viral diseases, including post-COVID-19 manifestations, could serve as potential diagnostic prognostic biomarkers. This review aimed discuss most recent findings on gut microbiota its relationship sequelae PACS. Elucidating these mechanisms help develop personalized non-invasive clinical strategies identify at a higher risk experiencing complications Moreover, highlights importance targeting composition avoid possible prophylactic therapeutic measures against PACS in future studies.

Language: Английский

---

Feeding Sows with Multi-Species Probiotics During Late Pregnancy and the Lactating Period Influences IgA Concentration in Colostrum and Subsequently Increases the Survival Rate of Piglets in Porcine Epidemic Diarrhea Outbreak Herd

Animals, Journal Year: 2025, Volume and Issue: 15(1), P. 103 - 103

Published: Jan. 5, 2025

Porcine epidemic diarrhea (PED) virus is an important cause of in sows and piglets [...]

Language: Английский

---

Therapeutic potential of short-chain fatty acids for acute lung injury: a systematic review and meta-analysis of preclinical animal studies

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 8, 2025

Short-chain fatty acids (SCFAs), derived from the fermentation of dietary fiber by intestinal commensal bacteria, have demonstrated protective effects against acute lung injury (ALI) in animal models. However, findings shown variability across different studies. It is necessary to conduct a comprehensive evaluation efficacy these treatments and their consistency. This systematic review meta-analysis aimed explore SCFAs on ALI based preclinical research evidence, order provide new treatment strategies for ALI. We included studies that tested study was performed according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. A search relevant conducted PubMed, Embase, Web Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) databases up February 2024. The data were extracted accordance with established selection criteria, risk bias evaluated each study. total 16 articles finally meta-analysis. results indicated significantly reduced wet-to-dry weight (SMD = -2.75, 95% CI -3.46 -2.03, p < 0.00001), scores -5.07, -6.25 -3.89, myeloperoxidase -3.37, -4.05 -2.70, tumor necrosis factor-alpha -3.31, -4.45 -2.16, 0.00001) malondialdehyde -3.91, -5.37 -2.44, levels models subgroup analysis varies dosage duration treatment. can reduce inflammation oxidative stress clinical deserves further in-depth research. https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=584008, CRD42024584008.

Language: Английский

---

Fermented Lignan-Enriched Soy Beverage Ameliorates the Metabolic Effects of a High-Fat Diet on Female Mice

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: 73(9), P. 5194 - 5207

Published: Feb. 22, 2025

Fermented vegetable beverages have potential beneficial effects on the health associated with production of bioactive flavonoids and lignans by selected bacterial strains. Here, we studied a soy beverage fermented Bifidobacterium pseudocatenulatum INIA P815, both supplemented lignan extracts, in female mouse model high-fat diet followed for 16 weeks. The induced an increase adipose tissue plasma cholesterol as well modified fecal microbiota. Mice groups receiving any showed reduction mean area ovarian fat adipocytes exhibited tissues, accompanied higher antioxidant activity plasma. group mice subjected to also demonstrated lower levels, short-chain fatty acid production, levels daidzein, genistein, enterolignans, herbacetin organs. Moreover, fertility that received was enhanced, resulting percentage blastocysts per mouse. Therefore, consumption B. P815 could be favoring ameliorating, some extent, diet.

Language: Английский

---

Structure characterization and rheological properties of novel polysaccharides extracted from mango seed kernel, and their effects on immunomodulation and human gut microbiota

Food Chemistry, Journal Year: 2025, Volume and Issue: 479, P. 143841 - 143841

Published: March 10, 2025

Language: Английский

---

In Vivo Evidence on the Emerging Potential of Non-Digestible Oligosaccharides as Therapeutic Agents in Bacterial and Viral Infections

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1068 - 1068

Published: March 19, 2025

The issue of antibiotic-resistant bacterial infections, coupled with the rise in viral pandemics and slow development new antibacterial antiviral treatments, underscores critical need for novel strategies to mitigate spread drug-resistant pathogens, enhance efficacy existing therapies, accelerate discovery deployment innovative antimicrobial solutions. One promising approach address these challenges is dietary supplementation non-digestible oligosaccharides (NDOs). NDOs, including human milk (HMOs), play a vital role shaping sustaining healthy gut microbiota. Beyond stimulating growth activity beneficial bacteria, NDOs can also interact directly pathogenic bacteria viruses. Their properties arise from their unique interactions pathogens ability modulate host’s immune system. function as decoy receptors, inhibit pathogen growth, bind toxins, stimulate host response, exhibit anti-biofilm properties, barrier protection. However, notable gap exists comprehensive assessment vivo clinical data on this topic. This review aims provide an in-depth overview evidence related effects various HMOs, focus discussing possible mechanisms action.

Language: Английский

---

The Impact of Antibiotic Therapy on Intestinal Microbiota: Dysbiosis, Antibiotic Resistance, and Restoration Strategies

Antibiotics, Journal Year: 2025, Volume and Issue: 14(4), P. 371 - 371

Published: April 3, 2025

The human gut microbiota—an intricate and dynamic ecosystem—plays a pivotal role in metabolic regulation, immune modulation, the maintenance of intestinal barrier integrity. Although antibiotic therapy is indispensable for managing bacterial infections, it profoundly disrupts microbial communities. Such dysbiosis typified by diminished diversity shifts community structure, especially among beneficial genera (e.g., Bifidobacterium Eubacterium), fosters antibiotic-resistant strains horizontal transfer resistance genes. These alterations compromise colonization resistance, increase permeability, amplify susceptibility to opportunistic pathogens like Clostridioides difficile. Beyond gastrointestinal disorders, emerging evidence associates with systemic conditions, including chronic inflammation, syndrome, neurodegenerative diseases, underscoring relevance microbiota–gut–brain axis. recovery pre-existing communities post-antibiotic highly variable, influenced drug spectrum, dosage, treatment duration. Innovative interventions—such as fecal microbiota transplantation (FMT), probiotics, synbiotics, precision microbiome therapeutics—have shown promise counteracting mitigating its adverse effects. therapies align closely stewardship programs aimed at minimizing unnecessary use preserve curtail spread multidrug-resistant organisms. This review emphasizes pressing need microbiota-centered strategies optimize administration, promote long-term health resilience, alleviate disease burden associated antibiotic-induced dysbiosis.

Language: Английский

---

Novel Anti-Herpes Simplex Activity of Chryseobacterium indologenes: Genomic and Metabolomic Insights

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107534 - 107534

Published: April 1, 2025

Language: Английский

---