Lactobacillus sp. for the Attenuation of Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice DOI Creative Commons
Titilayo Olotu, Jessica M. Ferrell

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2488 - 2488

Published: Dec. 3, 2024

Probiotics are studied for their therapeutic potential in the treatment of several diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). Part significant progress made understanding pathogenesis steatosis has come from identifying complex interplay between gut microbiome and function. Recently, probiotics have shown beneficial effects prevention MASLD rodent models clinical trials. Numerous studies demonstrated promising lactic acid bacteria, especially genus Lactobacillus. Lactobacillus is a prominent bile hydrolase bacterium that involved biotransformation acids. This genus’ modulation microbiota also contributes to overall health; it controls microbial overgrowth, shapes intestinal pool, alleviates inflammation. narrative review offers comprehensive summary gut-liver axis attenuate MASLD. It highlights roles hepatic lipid metabolism, insulin resistance, inflammation fibrosis, synthesis attenuating

Language: Английский

A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses DOI Creative Commons
Alice Njolke Mafe, Great Iruoghene Edo,

Osamah S. Majeed

et al.

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

Citations

8
Lactic acid bacteria: Nature, Characterization, Mode of action, Products and Applications DOI
Patrick Othuke Akpoghelie, Great Iruoghene Edo,

Ali B.M. Ali

et al.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

4
Probiotic Functions in Fermented Foods: Anti-Viral, Immunomodulatory, and Anti-Cancer Benefits DOI Creative Commons
Yeonhee Pyo, Ki Han Kwon,

Yeon Ja Jung

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2386 - 2386

Published: July 28, 2024

Fermented foods can provide many benefits to our health. These are created by the action of microorganisms and help support digestive health immune system. include yogurt,

Language: Английский

Citations

11
Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis DOI Creative Commons

Tingting Luo,

Qingya Che,

Ziyi Guo

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 9, 2024

The gut microbiota offers numerous benefits to the human body, including promotion of nutrient absorption, participation in metabolic processes, and enhancement immune function. Recent studies have introduced concept gut-organ axis, which encompasses interactions such as gut-brain gut-liver gut-lung axis. This underscores complex interplay between various organs tissues, brain, heart, lungs, liver, kidneys, muscles, bones. Growing evidence indicates that can influence onset progression multi-organ system diseases through their effects on Traditional Chinese medicine has demonstrated significant efficacy regulating gastrointestinal system, leveraging its unique advantages. Considerable advancements been made understanding role axis within mechanisms action traditional medicine. review aims elucidate roles health, explore potential connections microbiota, examine therapeutic microbiota-gut-organ Furthermore, addresses limitations challenges present current research while proposing directions for future investigations this area.

Language: Английский

Citations

4
ПРОБІОТИКИ ЯК АЛЬТЕРНАТИВНІ АНТИМІКРОБНІ ЗАСОБИ DOI
Mykola Spivak, Л. А. Сафронова

Інфекційні хвороби, Journal Year: 2025, Volume and Issue: 1, P. 4 - 8

Published: March 6, 2025

Антибіотики є одними з найвидатніших досягнень у медицині, які забезпечили можливість лікувати та контролювати інфекційних хворих. Однак їх широке і неналежне використання призвело до зростання поширеності антибіотикорезистентності патогенів за останні кілька десятиліть. Багато антибіотиків стали менш ефективними або повністю безсилими проти бактерійних інфекцій. Тому стійкість однією найсерйозніших глобальних загроз для охорони здоров’я, яка примушує нас вдаватися негайних заходів. Сьогодні, коли вибір лікування зростаючої кількості захворювань, спричинених мультирезистентними штамами бактерій, обмежений, дослідження нових, ефективних безпечних засобів різних інфекцій критично важливим. Одним із потенційних рішень може стати профілактики контролю недуг пробіотиків, характеризуються антимікробними й імуномодулювальними властивостями позитивним впливом на здоров’я людини. Обмеження застосування збільшення пробіотиків медицині допоможе зменшити поширеність антибіотикорезистентних патогенних мікроорганізмів навколишньому середовищі уникнути виникнення побічних ефектів, пов’язаних прийомом антибіотиків. Хоча продуктів основі не вирішить проблему антибіотикорезистентності, вони мають потенціал як альтернатива традиційним антибіотикам додаткова терапія мультирезистентних патогенів.

Citations

0
Exploring the Gut Microbiome's Influence on Peptic Ulcer Disease: Mechanistic Insights, Pharmacological Implications, and Emerging Therapeutic Strategies DOI Open Access

D. MUKHERJEE,

Sayak Tanbir,

Shiladittya Mondal

et al.

Journal of Drug Delivery and Therapeutics, Journal Year: 2025, Volume and Issue: 15(4), P. 209 - 218

Published: April 15, 2025

Background: The gastrointestinal disorder Peptic Ulcer Disease (PUD) leads to mucosal damage in either stomach or duodenal tissue because of acid-peptic injury. available evidence demonstrates that Helicobacter pylori (H. pylori) infection and nonsteroidal anti-inflammatory drug (NSAID) usage serve as proven ulcer causes but new research shows the gut microbiome contributing development therapeutic approaches. Objective: purpose this section is examine standard H. process while examining host immune responses through microbial alterations their effect on PUD disease progression. Methods: This study reviewed multiple articles how bacteria affect epithelial cells studying inflammatory pathways well metabolites particularly short-chain fatty acids (SCFAs). review examined different pharmacy-based natural therapies from perspective ability modulate microbiome. Results: Non-H. Pylori gastric by activating pro-inflammatory cytokines which homeostasis disturbances SCFA production. formation gets worse dysbiosis makes intestines more sensitive oxidative stress simultaneously making protective layer weaker. Antibiotics together with proton pump inhibitors composition treatments including curcumin combined ginger probiotics both contribute recovery healing ulcers. Conclusion: Previous about microbiome's role pathogenesis forms a base for future tailored strategies. Combining microbiome-based methods traditional medical protocols produces better management strategies ulcers improved healthcare results patients. Keywords:Peptic Disease, Gut Microbiota, Microbial Dysbiosis, Immunoglobulin A (IgA), Gastrointestinal Inflammation, Mucosal Homeostasis

Language: Английский

Citations

0
Gut Mycobiome: Latest Findings and Current Knowledge Regarding Its Significance in Human Health and Disease DOI Creative Commons
Bogdan Gașpar,

Oana Alexandra Roşu,

Robert Mihai Enache

et al.

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(5), P. 333 - 333

Published: April 22, 2025

The gut mycobiome, the fungal component of microbiota, plays a crucial role in health and disease. Although fungi represent small fraction ecosystem, they influence immune responses, homeostasis, disease progression. mycobiome’s composition varies with age, diet, host factors, its imbalance has been linked to conditions such as inflammatory bowel (IBD) metabolic disorders. Advances sequencing have expanded our understanding fungi, but challenges remain due methodological limitations high variability between individuals. Emerging therapeutic strategies, including antifungals, probiotics, fecal microbiota transplantation, dietary interventions, show promise require further study. This review highlights recent discoveries on interactions bacteria, disease, potential clinical applications. A deeper contributions will help develop targeted microbiome-based therapies.

Language: Английский

Citations

0
Intervening Mechanisms of Amitriptyline Combined With Domperidone on Functional Dyspepsia Rats DOI
Xu Pei,

Yue Ma,

Jingyan Gu

et al.

Neurogastroenterology & Motility, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

ABSTRACT Objectives The long‐term recurrent symptoms of functional dyspepsia (FD) and the prolonged course disease lead to varying degrees psychological disorders in patients. study focuses on investigating effects drug amitriptyline FD rats, aiming provide a basis for mechanism action treating from clinical perspective. Methods A rat model was used assess gastric emptying, intestinal propulsion, visceral sensitivity, behavioral states after treatment with amitriptyline, domperidone, or both drugs. concentrations 5‐hydroxytryptamine (5‐HT) expression related signaling molecules were measured using ELISA, RT‐qPCR, Western blot. Gastrointestinal motility also evaluated through muscle perfusion experiments, composition gut microbiota analyzed 16S rRNA sequencing. Results Amitriptyline, either alone combined improved scores, food intake, mental status rats. It increased 5‐HT plasma gastrointestinal tissue, decreased altered expressions 5‐HT2B receptor, phospholipase C‐β 2 , IP 3 calcium‐activated chloride channel anoctamin 1 (ANO1) tissues. Although had no significant effect vivo transit rates, it significantly inhibited contractile activity isolated strips exhibited anticholinergic effects. Additionally, domperidone relative abundance Actinomycetota specifically Eggerthellales order microbiota. Conclusions combination relieves anxiety depression, improves by targeting 5‐HT2BR, PLCβ R pathways, modulates This integrated approach alleviates multiple mechanisms presenting promising therapeutic strategy.

Language: Английский

Citations

0
The association between the intake of polyunsaturated fatty acids and chronic constipation and diarrhea: NHANES 2005–2010 DOI Creative Commons
Ping Lin, Wei Wang, Yun Zhou

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 6, 2025

Polyunsaturated fatty acids (PUFAs) have shown notable protective effects in various diseases. This study aims to investigate the associations between PUFAs intake and both chronic constipation (CC) diarrhea (CD). Data from three survey cycles (2005-2006, 2007-2008, 2009-2010) of National Health Nutrition Examination Survey (NHANES) were used for analysis. 24-hour dietary recall interviews employed evaluate intake. The CC CD analyzed via multivariable weighted logistic regression (WLR). Furthermore, stratified analysis restricted cubic splines carried out. 7723 participants included, among whom 545 (8.35%) patients 579 (7.50%) patients. According results MLR, a nonlinear association was found (P < 0.05), where increased daily related declined prevalence [OR = 0.976 (0.959, 0.993), P 0.007] fully adjusted model. However, there no significant evidence an > 0.05). negatively associated with not strongly CD. It suggested that adjusting may alleviate symptoms. Not applicable.

Language: Английский

Citations

0
Leveraging Lactobacillus plantarum probiotics to mitigate diarrhea and Salmonella infections in broiler chickens DOI Creative Commons
Seyed Mehrdad Mirsalami, Mahsa Mirsalami

AMB Express, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 18, 2024

Language: Английский

Citations

3